Challenging nanoparticles: a target of personalized adhesion prevention strategy

Inhibition of oxygen scavengers realized by peritoneal macrophages: an adhesion prevention target?

“…We have already pointed out that a design of ideal nanoparticles should become a target of personalized adhesion prevention strategy in the future 4,5 and therefore, we read with great interest the article by Shin et al that was recently published in your journal. 6 This article explores the potential of postoperative adhesion prevention by nanofibers of poly(lactic-co-glycolic acid) (PLGA) loaded with epigallocatechin-3-O-gallate (EGCG), which is the most bioactive polyphenolic compound extracted from green tea.…”

“…Ospan A Mynbaev [1][2][3][4] Marina Yu eliseeva 1,2 Oktay t Kadayifci 1,5 tahar Benhidjeb 1,6 Michael Stark …”

Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model

“…Previous studies proved that tissue adhesions were formed in the early period after surgery (generally in the first week) 10 11 . Therefore, researchers proposed to apply pharmacological or barrier approaches in the surgery to prevent the formation of adhesion 12 13 14 15 . Many pharmacological agents (including anti-inflammatory drugs, fibrinolytic drugs, and antibiotics) were used, but the therapeutic effects were limited, which may cause by the fast intraperitoneal clearance 16 .…”