Challenging surgical treatment of giant retroperitoneal liposarcoma: A case report

Wei, Xiaoyi; Qin, Yuyue; Ouyang, Song; Qian, Jun; Tu, Song; Yao, Jiaxi

doi:10.3892/ol.2022.13434

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…Computed Tomography (CT) is widely used for the diagnosis and preoperative evaluation of Retroperitoneal Liposarcoma (RPLPS) (15). However, Magnetic Resonance Imaging (MRI) offers higher resolution of soft tissues, enabling more accurate diagnosis of retroperitoneal tumors.…”

Section: Discussionmentioning

confidence: 99%

Recurrent retroperitoneal liposarcoma with multiple surgeries: a case report

Wang,

Song,

Song

et al. 2024

Front. Oncol.

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Retroperitoneal liposarcoma (RPLPS) is a rare malignant tumor that is typically treated with surgical resection. However, RPLPS often has a high rate of local recurrence, making it crucial to explore new treatment options. In this report, we present the case of a middle-aged woman who experienced seven recurrences and underwent seven surgeries following the initial resection. Currently, the patient’s condition remains stable after the eighth surgery. Although there have been numerous reports of RPLPS cases both domestically and internationally, instances of repeated recurrence like this are exceptionally rare. Therefore, we have gathered the patient’s case data and conducted a retrospective analysis, incorporating relevant literature, to enhance the understanding of this disease among clinical practitioners.

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Section: Discussionmentioning

confidence: 99%

Recurrent retroperitoneal liposarcoma with multiple surgeries: a case report

Wang,

Song,

Song

et al. 2024

Front. Oncol.

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“…The classification of LPS includes five histologic subtypes: well-differentiated/atypical lipomatous tumor (WDLPS); dedifferentiated liposarcoma (DDLPS); myxoid (round cell) liposarcoma (MRCLPS); pleomorphic liposarcoma (PLPS); and myxoid liposarcoma (MLPS) [ 3 ]. Surgical excision is the therapeutic strategy for most LPS, and radiation therapy is applied for treating larger primary extremity limb tumors as preoperative adjuvant therapy [ 4 , 5 ]. Although these treatments provide good controls of the local lesions, remote recurrence occurs in 40% to 50% of patients indicating that the disease is progressing [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Prognostic and Therapeutic Significance of Cell Cycle Regulator CENPF: A Potential Biomarker of Prognosis and Immune Microenvironment for Patients with Liposarcoma

Lian

Zhao

Han

et al. 2023

IJMS

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Liposarcoma (LPS) is one of the most common subtypes of sarcoma with a high recurrence rate. CENPF is a regulator of cell cycle, differential expression of which has been shown to be related with various cancers. However, the prognostic value of CENPF in LPS has not been deciphered yet. Using data from TCGA and GEO datasets, the expression difference of CENPF and its effects on the prognosis or immune infiltration of LPS patients were analyzed. As results show, CENPF was significantly upregulated in LPS compared to normal tissues. Survival curves illustrated that high CENPF expression was significantly associated with adverse prognosis. Univariate and multivariate analysis suggested that CENPF expression could be an independent risk factor for LPS. CENPF was closely related to chromosome segregation, microtubule binding and cell cycle. Immune infiltration analysis elucidated a negative correlation between CENPF expression and immune score. In conclusion, CENPF not only could be considered as a potential prognostic biomarker but also a potential malignant indicator of immune infiltration-related survival for LPS. The elevated expression of CENPF reveals an unfavorable prognostic outcome and worse immune score. Thus, therapeutically targeting CENPF combined with immunotherapy might be an attractive strategy for the treatment of LPS.

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A case report of retroperitoneal liposarcoma

Bao,

Zhang,

Ding

et al. 2024

Medicine

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Background: Retroperitoneal liposarcoma is a rare and complex tumor originating from the mesenchymal tissues, with no specific manifestations in the early stage, and a large tumor size in the late stage. Patients often consult a physician because of large abdominal mass, increased abdominal circumference, and abdominal pain, and rarely because of leukocytosis. Patient concerns: A 54-year-old female presented to our hospital with complaints of “abdominal distension for over 3 months, left lumbar pain for over 2 months.” Considering the comprehensive symptoms, examinations, computed tomography scans, and pathological results, the possibility of retroperitoneal liposarcoma is high. Diagnoses: Retroperitoneal liposarcoma with leukocytosis. Interventions: Open retroperitoneal mass excision along with transcystoscopic left ureteral Double-J Ureterl Stent Insertion tube placement and left nephrectomy. Outcomes: The postoperative pathological findings of the abdominal mass, combined with morphological and immunohistochemical results, are consistent with retroperitoneal liposarcoma. The patient had no recurrence in 7 months of postoperative follow-up conducted on the telephone and is now in continued follow-up. Conclusion: Retroperitoneal liposarcoma is highly malignant and prone to recurrence. Radical surgery is currently the primary treatment modality for patients with this condition. Analogous to cancer patients, those with elevated white blood cell counts and retroperitoneal liposarcoma may have poor prognoses, with a high likelihood of local recurrence and distant metastasis. Close postoperative follow-up is necessary. Therefore, regular postoperative review of blood routine may be a relatively economical and convenient method for the early detection of recurrence and metastasis of retroperitoneal liposarcoma.

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Challenging surgical treatment of giant retroperitoneal liposarcoma: A case report

Cited by 6 publications

References 20 publications

Recurrent retroperitoneal liposarcoma with multiple surgeries: a case report

Recurrent retroperitoneal liposarcoma with multiple surgeries: a case report

Deciphering the Prognostic and Therapeutic Significance of Cell Cycle Regulator CENPF: A Potential Biomarker of Prognosis and Immune Microenvironment for Patients with Liposarcoma

A case report of retroperitoneal liposarcoma

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