Chang-wei-qing, a Chinese herbal formula, ameliorates colitis-associated tumour development via inhibiting NF-κB and STAT3 signalling pathway

Wan, Guangsheng; Xie, Manli; Zhang, Xinyan; Li, Meiying

doi:10.1080/13880209.2019.1577465

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…Various herbal medicines have been shown to possess potential therapeutic effects on DSS-induced colitis in mice [21,22]. Studies mainly focus on in ammatory cytokines and oxidative stress in order to explain possible mechanisms of action of herbal formulas [18,23,24]. Our study is the rst to show the effect of Mongolian multicomponent medicine on epithelial damage and tight junction protein expressions in experimental colitis.…”

Section: Discussionmentioning

confidence: 91%

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2019

Cent Asian J Med Sci

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Objectives: To examine the therapeutic effects of buteelch-5, a traditional formula on DSSinduced colitis in C57/BL6 mice and its possible mechanisms. Methods: Colitis in mice was induced by oral administration of 5% dextran sulfate sodium (DSS) for seven days. On the eighth day after administration of DSS, buteelch-5 (500 mg/kg, twice a day) was given orally to mice for ve consecutive days. Cipro oxacin (50 mg/kg, once a day for 5 days) was given to mice as a comparison. Two hours after the last administration of buteelch-5 and cipro oxacin, mice were euthanized, and colon tissues were removed. Protein and mRNA levels of occludin, claudin-1 and zonula occludens (ZO)-1 in colon tissues were determined by western blot and real time-qPCR respectively. Histopathological analysis of colon tissues was performed. Results: Histological analysis revealed successful establishments of colitis models. Treatment with buteelch-5 markedly inhibited DSS-induced colon injury. Furthermore, buteelch-5 increased (2.14-2.67 fold) the occludin, claudin and ZO-1 protein and mRNA levels in colon tissues of mice administered with DSS. Signi cant increase was observed in occludin mRNA levels after buteelch-5 treatment (p<.05). Conclusion: Buteelch-5 improves microscopic in ammation and increases tight junction protein expressions such as occludin, claudin, and ZO-1 in mice with DSS-induced colitis.

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Section: Discussionmentioning

confidence: 91%

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2019

Cent Asian J Med Sci

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“…The NF-jB signalling pathway plays a key role in colitis-associated colorectal tumorigenesis. It has been reported that activation of the NF-jB signalling pathway may be essential for the progression of colitis to cancer (Wan et al 2019;Jiang et al 2020).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that activation of the NF-κB signalling pathway may be essential for the progression of colitis to cancer (Wan et al. 2019 ; Jiang et al. 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation

Liu

Gao

Wen

et al. 2021

Pharmaceutical Biology

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Context: Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain. Objective: We investigated the potential beneficial effects of tanshinone IIA in a colitis-associated colorectal tumorigenesis mouse model and its underlying mechanisms. Materials and methods: Male C57BL/6 mice were treated with azoxymethane (AOM) 10 mg/kg body weight and dextran sulphate sodium (2.5% DSS) to induce a colitis-associated cancer model. Tanshinone IIA (200 mg/kg body weight) was given to the mice intraperitoneally. After 12 weeks, all mice were sacrificed to measure tumour formation, intestinal permeability, neutrophil infiltration, and colonic inflammation. In addition, whether tanshinone IIA has inhibitory effects on neutrophil activation was determined through in vitro investigations. Results: We observed that tanshinone IIA significantly decreased tumour formation in AOM/DSS-treated mice compared to AOM/DSS-treated alone mice (0.266 ± 0.057 vs. 0.78 ± 0.153, p ¼ 0.013). Tanshinone IIA also decreased intestinal permeability compared to that in AOM/DSS-treated alone mice (3.12 ± 0.369 vs. 5.06 ± 0.597, p ¼ 0.034) and consequently reduced neutrophil infiltration of the colonic mucosa (53.25 ± 8.85 vs. 107.6 ± 13.09, p ¼ 0.014) as well as intestinal inflammation in mice. Mechanistically, tanshinone IIA downregulated the NF-jB signalling pathway in the colonic tumours of AOM/DSS-treated mice. In vitro assays further validated that tanshinone IIA suppressed LPS-induced neutrophil activation. Conclusion: These data suggest that tanshinone IIA alleviates colorectal tumorigenesis through inhibition of intestinal inflammation. Tanshinone IIA may have a therapeutic potential for CRC in clinical practice.

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“…[Asteraceae; Atractylodis rhizoma]. Wan et al (2019) intervened AOM/DSS induced mice with different intervention doses of CWQ (5, 10 mg/kg) for 89 days. Bifico (4.2 g/kg) was used as the positive control.…”

Section: Intervention Of Crosstalk Between Intestinal Microbiota and ...mentioning

confidence: 99%

Advances in research on the effectiveness and mechanism of Traditional Chinese Medicine formulas for colitis-associated colorectal cancer

Wei

Leng²,

Li³

et al. 2023

Front. Pharmacol.

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Inflammatory bowel disease (IBD) can progress into colitis-associated colorectal cancer (CAC) through the inflammation-cancer sequence. Although the mechanism of carcinogenesis in IBD has not been fully elucidated, the existing research indicates that CAC may represent a fundamentally different pathogenesis pattern of colorectal cancer. At present, there is no proven safe and effective medication to prevent IBD cancer. In recent years, Chinese medicine extracts and Chinese medicine monomers have been the subject of numerous articles about the prevention and treatment of CAC, but their clinical application is still relatively limited. Traditional Chinese Medicine (TCM) formulas are widely applied in clinical practice. TCM formulas have demonstrated great potential in the prevention and treatment of CAC in recent years, although there is still a lack of review. Our work aimed to summarize the effects and potential mechanisms of TCM formulas for the prevention and treatment of CAC, point out the issues and limitations of the current research, and provide recommendations for the advancement of CAC research in the future. We discovered that TCM formulas regulated many malignant biological processes, such as inflammation-mediated oxidative stress, apoptosis, tumor microenvironment, and intestinal microecology imbalance in CAC, through a review of the articles published in databases such as PubMed, SCOPUS, Web of Science, Embase, and CNKI. Several major signal transduction pathways, including NF-κB, STAT3, Wnt/β-catenin, HIF-1α, and Nrf2, were engaged. TCM formula may be a promising treatment candidate to control the colitis-cancer transformation, however further high-quality research is required.

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Chang-wei-qing, a Chinese herbal formula, ameliorates colitis-associated tumour development via inhibiting NF-κB and STAT3 signalling pathway

Cited by 11 publications

References 24 publications

Untitled

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Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation

Advances in research on the effectiveness and mechanism of Traditional Chinese Medicine formulas for colitis-associated colorectal cancer

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