Change in blood flow velocity demonstrated by Doppler ultrasound in upper limb after axillary dissection surgery for the treatment of breast cancer

Matheus, Carolina Nascimben; Guirro, Elaine Caldeira de Oliveira

doi:10.1007/s10549-011-1456-8

Cited by 27 publications

(6 citation statements)

References 41 publications

(44 reference statements)

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“…The first group consisted of studies measuring the blood flow velocity (mainly brachial artery and vein). 13 14 15 16 17 18 19 A positive correlation between an increase in blood flow (compared with the contralateral arm) and the presence of lymphedema was found in seven studies. The second group comprised studies measuring the thickness of the skin and subcutaneous tissue.…”

Section: Resultsmentioning

confidence: 90%

The Use of Ultrasound Imaging for Upper Extremity Lymphedema after Breast Cancer: A Systematic Review

Canales-Lachén

Asúnsolo

Manrique

et al. 2022

J Reconstr Microsurg

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Background The aim of this study was to analyze the different applications of ultrasound (US) in upper extremity lymphedema (UEL) after breast cancer. Methods A systematic review of the literature was performed in line with the PRISMA statement using MEDLINE/PubMed databases from January 1970 to December 2021. Articles describing the application of US in patients with UEL after breast cancer were included. The quality of the study, the level of reproducibility, and the different applications and type of US technique were analyzed. Results In total, 30 articles with 1,193 patients were included in the final review. Five different applications were found: (1) diagnosis of UEL (14 studies found a direct correlation between lymphedema and morphological and/or functional parameters); (2) staging/severity of UEL (9 studies found a direct correlation between the clinical stage and the soft-tissue stiffness/texture/thickness); (3) therapeutic assessment (3 studies found an improvement in the circulatory status or in the muscle/subcutaneous thickness after conservative treatments); (4) prognosis assessment of UEL (1 study found a correlation between the venous flow and the risk of UEL); and (5) surgical planning (3 studies determined the location of the lymphatic vessel for lymphovenous anastomosis [LVA] surgery). Conclusion Morphological and functional parameters have been correlated with the diagnosis, stage, therapeutic effect, prognosis of UEL, and surgical planning of LVA.

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Section: Resultsmentioning

confidence: 90%

The Use of Ultrasound Imaging for Upper Extremity Lymphedema after Breast Cancer: A Systematic Review

Canales-Lachén

Asúnsolo

Manrique

et al. 2022

J Reconstr Microsurg

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“…These changes in DMN-cerebellar connectivity may be caused by a chronic vertebral-basilar insufficiency in patients as a long-term effect of breast cancer surgery and/or radiation therapy, such as local fibrous-atrophic changes in the postoperative area and hypertrophy of the scalenus muscles, which leads to the spasming of the vertebral artery on the treatment side [46,47]. This assumption requires further study and comparison with data from other imaging techniques, such as ultrasounds of the arteries in the neck [48].…”

Section: Discussionmentioning

confidence: 99%

Functional Network Connectivity Reveals the Brain Functional Alterations in Breast Cancer Survivors

Bukkieva

Поспелова

Efimtsev

et al. 2022

JCM

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Different neurological and psychiatric disorders such as vertebrobasilar insufficiency, chronic pain syndrome, anxiety, and depression are observed in more than 90% of patients after treatment for breast cancer and may cause alterations in the functional connectivity of the default mode network. The purpose of the present study is to assess changes in the functional connectivity of the default mode network in patients after breast cancer treatment using resting state functional magnetic resonance imaging (rs-fMRI). Rs-fMRI was performed using a 3.0T MR-scanner on patients (N = 46, women) with neurological disorders (chronic pain, dizziness, headaches, and/or tinnitus) in the late postoperative period (>12 months) after Patey radical mastectomy for breast cancer. According to the intergroup statistical analysis, there were differences in the functional connectivity of the default mode network in all 46 patients after breast cancer treatment compared to the control group (p < 0.01). The use of rs-fMRI in in breast cancer survivors allowed us to identify changes in the functional connectivity in the brain caused by neurological disorders, which correlated with a decreased quality of life in these patients. The results indicate the necessity to improve treatment and rehabilitation methods in this group of patients.

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“…In the few reports that have previously employed duplex ultrasound to identify vascular abnormalities in breast cancer patients, the rate of vascular findings varies significantly between studies. [13][14][15][16][17][18] The purpose of this study is to estimate the prevalence of functional venous stenosis in patients with BCRL and thus, determine whether scar decompression is a necessary part of physiologic lymphedema surgery.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Scar Decompression in Managing Breast Cancer-Related Lymphedema: Is it Needed?

Finkelstein,

Treger,

Shittu

et al. 2024

J Reconstr Microsurg

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Background: Mastectomy, axillary lymph node dissection, and irradiation for breast cancer commonly result in perivascular and axillary scarring. This scarring is thought to cause functional venous stenosis that leads to downstream venous hypertension in the affected extremity. Standard surgical practice is to decompress perivascular scarring at the time of physiologic lymphedema surgery in patients with breast cancer-related lymphedema (BCRL). However, it is unknown whether this scar release influences surgical outcomes. The purpose of this study is to evaluate prevalence of functional venous stenosis in patients with BCRL and determine whether scar decompression is a necessary step in physiologic lymphedema surgery. Methods: The authors conducted a retrospective review of 64 patients with unilateral BCRL that presented to our lymphedema center between January 2020 and October 2022. Radiologist reports of venous duplex ultrasound for the bilateral upper extremities identified any disturbances in venous flow or indications of venous stenosis. Results: Of the 64 patients with BCRL, 78% (n=50) had prior axillary lymph node dissection. Forty-seven (73%) patients completed ultrasound imaging, of which, one patient (2%) had venous stenosis in the affected lymphedematous extremity identified on duplex ultrasound that may have suggested functional scarring. Vascularized lymph node transfer (VLNT) without scar decompression was performed in six patients (9%). Average preoperative lymphedema life impact scale (LLIS) and L-dex scores were 35 and 19 units, with a mean decrease of 23 (67%) and 6 (30%) units postoperatively. Conclusion: Most patients with BCRL did not have identifiable functional venous stenosis on duplex ultrasound, apart from one patient with suspected post-thrombotic changes. All six patients that received VLNT without scar decompression had a successful outcome with decreased measures of lymphedema postoperatively. Scar decompression may therefore be unnecessary in physiologic lymphedema surgery, reducing operative times and avoiding risk of injury to neurovascular structures of the axilla.

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Change in blood flow velocity demonstrated by Doppler ultrasound in upper limb after axillary dissection surgery for the treatment of breast cancer

Cited by 27 publications

References 41 publications

The Use of Ultrasound Imaging for Upper Extremity Lymphedema after Breast Cancer: A Systematic Review

The Use of Ultrasound Imaging for Upper Extremity Lymphedema after Breast Cancer: A Systematic Review

Functional Network Connectivity Reveals the Brain Functional Alterations in Breast Cancer Survivors

Scar Decompression in Managing Breast Cancer-Related Lymphedema: Is it Needed?

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