Change in body composition in patients with achalasia before and after peroral endoscopic myotomy

Mizusawa, Takeshi; Sato, Hiroki; Kamimura, Kenya; Hashimoto, Satoru; Mizuno, Ken‐ichi; Kamimura, Hiroteru; Ikarashi, Satoshi; Hayashi, Kazunao; Takamura, Masaaki; Yokoyama, Junji; Terai, Shuji

doi:10.1111/jgh.14847

Cited by 3 publications

(1 citation statement)

References 30 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another part-retrospective, part-prospective Japanese study of 72 patients analyzed changes in weight before and 3 months after POEM [9]. Prospective assessment of body composition in 10 patients was performed using dual bioelectrical impedance analysis (BIA).…”

Section: Discussionmentioning

confidence: 99%

Changes in weight following peroral endoscopic myotomy: results from a North American center

2021

View full text Add to dashboard Cite

Background and study aims Weight loss is a feature of untreated achalasia. While weight gain after achalasia treatment is expected, little data exist about the extent of it, particularly after peroral endoscopic myotomy (POEM). We aimed to describe the changes in weight after POEM. Patients and methods A retrospective analysis was performed of patients from March 2016 to March 2020 undergoing POEM by an experienced operator at an academic referral center in Kingston, Ontario, Canada. Data examined included pre- and post-POEM body mass index (BMI), procedural characteristics, and Eckardt scores. Results Ninety-two patients underwent POEM during the study period, for 77 of whom follow-up data were available including BMI. Prior to POEM, the median BMI was 26. Six patients (7.8 %) were considered to be underweight, 24 (31.2 %) were normal, 26 (33.8 %) were pre-obese, and 21 (27.2 %) were obese. At a median follow-up of 15 months, the clinical success rate was 95 %. Patients in the normal weight and pre-obesity categories had a significant increase in weight post-POEM. Of the underweight patients, two (33.3 %) moved up to a normal weight category and two (33.3 %) became pre-obese. In the normal BMI category, eight (37.5 %) became pre-obese and one patient (4.2 %) became obese. Ten of the 26 pre-obese patients (38.4 %) were obese post-POEM. Seven of the obese patients (33.3 %) reached Class III (morbid) obesity at follow-up. Conclusions Patients may experience a marked increase in BMI following POEM, with over one-third of patients becoming pre-obese, obese or morbidly obese at follow-up in our study in a North American population. Further study is required to analyze weight gain patterns post-POEM.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in weight following peroral endoscopic myotomy: results from a North American center

2021

View full text Add to dashboard Cite

show abstract

The Malnutrition Universal Screening Tool can predict malnutrition in patients with esophageal achalasia

Milito

Aquilino

Lazzari

et al. 2020

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

Background: At present, little research has been done to clarify why some achalasia patients do not lose weight or are even obese and to investigate their nutritional status. The aim of this study was to identify predictive factors of malnutrition in these patients and to assess their response to treatment. Methods: We conducted a retrospective cohort study on consecutive patients referred to a tertiary-care center for laparoscopic or endoscopic treatment of achalasia. Demographics, anthropometric variables, presenting symptoms, and results of the objective investigation were recorded on a prospectively collected database. The severity of symptoms and the nutritional risk were assessed by the Eckardt score and the Malnutrition Universal Screening Tool (MUST), respectively, before and after treatment. Results. Between 2013 and 2019, 171 patients met the study inclusion criteria. There were 87 (50.9%) male and the median age was 53.0 (39–66) years. The median Eckardt score was 6 (interquartile range 3). Based on the MUST score, 121 (70.8%) patients were classified at moderate/high risk of malnutrition. Of these, 93 (76.9%) were overweight or obese. Compared to low-risk group, predictive factors of moderate/high risk of malnutrition were higher Eckardt score [odds ratio (OR) 1.63; 95% CI, 1.35–1.99], more severe dysphagia (OR 2.68, 95% CI, 1.66–4.30), and greater absolute weight loss (OR 2.37; 95% CI, 1.77–3.17). The latter was the only independent predictive factor of malnutrition (OR 2.54; 95% CI, 1.69–3.82). After treatment, the measured MUST score was 0 in 96% of patients. Conclusions: Over 70% of achalasia patients were at moderate/high risk of malnutrition. These individuals may benefit from a perioperative multidisciplinary approach including dietary intervention to stabilize weight and improve their nutritional status.

show abstract

Association between Clinical Characteristics and Sarcopenia or Sarcopenic Obesity in Crohn's Disease

Naruse,

Sato,

Takahashi

et al. 2024

Intern. Med.

View full text Add to dashboard Cite

Change in body composition in patients with achalasia before and after peroral endoscopic myotomy

Cited by 3 publications

References 30 publications

Changes in weight following peroral endoscopic myotomy: results from a North American center

Changes in weight following peroral endoscopic myotomy: results from a North American center

The Malnutrition Universal Screening Tool can predict malnutrition in patients with esophageal achalasia

Association between Clinical Characteristics and Sarcopenia or Sarcopenic Obesity in Crohn's Disease

Contact Info

Product

Resources

About