Change in common carotid artery diameter, distensibility and compliance in subjects with a recent history of impaired glucose tolerance

Dijk, van Jitse; Nijpels, Giel; Jw, Twisk; Steyn, Mieke; Jm, Dekker; Rj, Heine; Aj, Donker; Cd, Stehouwer

doi:10.1097/00004872-200018030-00009

Cited by 20 publications

(23 citation statements)

References 36 publications

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“…16 On the other hand, the role of hyperglycaemia in the pathophysiology of macro-angiopathy remains controversial and the prevention of macro-vascular events seems to involve the treatment of CV risk factors associated with DM, essentially HTN. 17 Several studies [35][36][37][38][39][40][41] have analysed the effect of DM on the arterial wall in an attempt to determine early indices of diabetic alteration. The results are heterogeneous but there is a general tendency toward an increase of the arterial stiffness in diabetic and in insulin resistant patients.…”

Section: Pulse Wave Velocity Pulse Pressure and Diabetesmentioning

confidence: 99%

Diabetes mellitus and renal failure: effects on large artery stiffness

et al. 2001

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Diabetes mellitus and end-stage renal disease are two pathologic entities associated with increased cardiovascular risk. Several studies have shown that arterial stiffness is increased in both cases and contributes to the increased risk. In order to determine the effect of diabetes and renal failure on arterial stiffness, we conducted a case-control study. One hundred and twentytwo diabetic patients were compared to 122 non-diabetic patients matched to the study group for sex, age, mean arterial pressure, number and localisation of the atherosclerotic alterations. Arterial stiffness was assessed by automatic measurement of the aortic pulse wave velocity (PWV) and by measuring the peripheral and carotid pulse pressure (PP) and reflected waves through analysis of the pulse wave using the principle of applanation tonometry. Aortic PWV was significantly higher in the

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Section: Pulse Wave Velocity Pulse Pressure and Diabetesmentioning

confidence: 99%

Diabetes mellitus and renal failure: effects on large artery stiffness

et al. 2001

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“…Premature conduit vessel arteriosclerosis predicts mortality in type 2 diabetes [3] and may be attenuated by therapeutic approaches with potential to lower glucose or blood pressure directly [4][5][6][7]. The independent association of FPG and 2-HPG indices with the haemodynamic consequence of early sclerosis (aortic stiffness) implies that modifiable structural mechanisms connect hyperglycaemia with vascular complications even within prediabetes thresholds of impaired glucose tolerance (IGT) [8][9][10][11] and impaired fasting glycaemia (IFG) [12,13]. These relationships are reported individually [11][12][13] or as a cumulative effect of the metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

“…The independent association of FPG and 2-HPG indices with the haemodynamic consequence of early sclerosis (aortic stiffness) implies that modifiable structural mechanisms connect hyperglycaemia with vascular complications even within prediabetes thresholds of impaired glucose tolerance (IGT) [8][9][10][11] and impaired fasting glycaemia (IFG) [12,13]. These relationships are reported individually [11][12][13] or as a cumulative effect of the metabolic syndrome. [14][15][16][17][18][19] and do not specifically address the relative independent strengths of FPG and 2-HPG associations with measures of arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity

et al. 2010

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Aims/hypothesis Non-invasive measures of aortic stiffness reflect vascular senescence and predict outcome in diabetes. Glucose-mediated elastic artery sclerosis may play an integral role in the development of macrovascular complications. We used carotid-femoral pulse wave velocity ( cf PWV) to quantify independent associations of fasting glucose, post-challenge glucose and derived insulin resistance (HOMA-IR) with aortic stiffness. Methods cf PWV was measured using a 4 MHz continuous wave Doppler ultrasound probe within groups with newly identified age-and sex-matched normal glucose metabolism (NGM), impaired glucose regulation (IGR) and diabetes mellitus populations (n=570, mean age 59.1, 56% male). Results After multivariate adjustment, IGR and diabetes were associated with significant aortic stiffening compared with NGM (adjusted cf PWV±SE: NGM, 9.15±0.12 m/s; IGR 9.76±0.11 m/s, p<0.001; diabetes, 9.89±0.12 m/s, p< 0.001). IGR stratification indicated that impaired fasting glucose (IFG; 9.71±0.12 m/s) and post-challenge (impaired glucose tolerance; 9.82±0.24 m/s) categories had similar cf PWV (p=0.83). Modelled predictors of cf PWV were used to assess independent metabolic associations with arterial stiffness. Fasting glucose concentration (β=0.10; 95% CI 0.05, 0.18; p=0.003), 2 h post-challenge glucose (β=0.14; 95% CI 0.02, 0.23; p<0.001) and HOMA-IR (β=0.20, 95% CI 0.05, 0.53; p<0.001) were independently related to cf PWV after adjustment for age, sex, mean arterial pressure, heart rate, body mass index, renal function and antihypertensive medication. Conclusions/interpretation IGR characterised by fasting or post-challenge hyperglycaemia is associated with significant vascular stiffening. Post-challenge glucose and HOMA-IR are the most powerful metabolic predictors of arterial stiffness, implying hyperglycaemic excursion and insulin resistance play important roles in the pathogenesis of arteriosclerosis.

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“…[6][7][8] Estimation of arterial stiffness has been reported to be a useful method for assessment of early preclinical atherosclerosis. 9) Nonetheless, the relationships between different arterial stiffness indices and glucose homeostasis status were reported individually 10,11) or as a cumulative effect of the metabolic syndrome. 12,13) It is rare that studies have specifi cally addressed the effects of different stages of glucose homeostasis on peripheral arterial stiffness index.…”

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confidence: 99%

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

et al. 2013

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SummaryPremature arteriosclerosis may be one of the mechanisms linking pre-diabetes mellitus (pre-DM) and cardiovascular disease. We sought to characterize premature arteriosclerosis in pre-DM using different arterial stiffness indices and to fi nd the independent contributors of this process. We recruited 33 patients without DM, 53 patients with pre-DM, and 34 subjects with DM. Both the compliance index (CI) and stiffness index (SI) were measured. Patients with pre-DM and DM had lower CI (3.8 ± 2.1 versus 5.2 ± 3.0 units; P < 0.05 and 3.6 ± 1.8 versus 5.2 ± 3.0 units; P < 0.05, respectively) and higher SI (8.0 ± 2.0 versus 6.7 ± 1.6 m/s; P < 0.01 and 9.4 ± 2.3 versus 6.7 ± 1.6 m/s; P < 0.001, respectively) than patients without DM. Using multivariate linear regression analysis, age, heart rate, and HOMA index were independent determinants for SI (whole model: R 2 = 0.47, P < 0.001), whereas male gender, hsCRP, and HOMA index were independent determinants for CI (whole model: R 2 = 0.34, P < 0.01). The HOMA index was an independent determinant for arterial stiffness. Increased insulin resistance may associate with increased arterial stiffness at peripheral arteries in pre-DM patients. (Int Heart J 2013; 54: 27-32)

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Change in common carotid artery diameter, distensibility and compliance in subjects with a recent history of impaired glucose tolerance

Cited by 20 publications

References 36 publications

Diabetes mellitus and renal failure: effects on large artery stiffness

Diabetes mellitus and renal failure: effects on large artery stiffness

Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity

Effects of Deranged Glucose Homeostasis on Peripheral Arterial Stiffness Index in Patients With Pre-Diabetes Mellitus

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