Change in core symptoms of borderline personality disorder by tDCS: A pilot study

Lisoni, Jacopo; Miotto, Paola; Barlati, Stefano; Calza, Stefano; Crescini, Alessandra; Deste, Giacomo; Sacchetti, Emilio; Vita, Antonio

doi:10.1016/j.psychres.2020.113261

Cited by 19 publications

(32 citation statements)

References 86 publications

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“…This evidence could have potential consequences for therapeutic interventions. In this sense, recent randomized controlled trials reported beneficial effects of non-invasive brain stimulation in BPD, reducing impulsivity and aggression and improving the cognitive control [ 52 , 53 , 54 , 55 ]. As non-invasive stimulation exerts effect both on synaptic plasticity and axonal pathways [ 56 ] and its efficacy is probably greater when plasticity is not compromised, the relative sparing of the triple network system morphology might support the efficacy of this treatment.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Structural Connectivity of the Triple Network System in Borderline Personality Disorder Is Associated with Behavioral Dysregulation

Quattrini

Magni

Lanfredi

et al. 2022

JCM

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Background: Core symptoms of Borderline Personality Disorder (BPD) are associated to aberrant connectivity of the triple network system (salience network [SN], default mode network [DMN], executive control network [ECN]). While functional abnormalities are widely reported, structural connectivity (SC) and anatomical changes have not yet been investigated. Here, we explored the triple network’s SC, structure, and its association with BPD clinical features. Methods: A total of 60 BPD and 26 healthy controls (HC) underwent a multidomain neuropsychological and multimodal MRI (diffusion- and T1-weighted imaging) assessment. Metrics (fractional anisotropy [FA], mean diffusivity [MD], cortical thickness) were extracted from SN, DMN, ECN (triple network), and visual network (control network) using established atlases. Multivariate general linear models were conducted to assess group differences in metrics and associations with clinical features. Results: Patients showed increased MD in the anterior SN, dorsal DMN, and right ECN compared to HC. Diffusivity increases were more pronounced in patients with higher behavioral dysregulation, i.e., suicidal attempting, self-harm, and aggressiveness. No differences were detected in network structure. Conclusions: These results indicate that the triple network system is impaired in BPD at the microstructural level. The preferential involvement of anterior and right-lateralized subsystems and their clinical association suggests that these abnormalities could contribute to behavioral dysregulation.

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Section: Discussionmentioning

confidence: 99%

Aberrant Structural Connectivity of the Triple Network System in Borderline Personality Disorder Is Associated with Behavioral Dysregulation

Quattrini

Magni

Lanfredi

et al. 2022

JCM

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“…Some studies have also linked the lDLPFC activity with cognitive control functions [73,74]. Hence, in contrast with Lisoni et al [65], Molavi et al…”

Section: Agg Re Ss Ivene Ss Impul S Ivit Y Clini C Alcond Iti On S An...mentioning

confidence: 96%

Non‐invasive neuromodulation can reduce aggressive behaviors in humans: A critical perspective

Volpe

Tagliente

Palmisano

et al. 2022

Journal of Forensic Sciences

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Containing aggressive behavior is an ongoing challenge in modern society. Aggressiveness is a multi‐level construct that can be driven by emotions (reactive aggression) or can be “cold‐blooded” and goal‐directed (proactive). Aggressive behavior could arise because of a misjudgment of others' intentions or can follow frontal brain lesions leading to a reduction of impulse control and emotion regulation. In the last few years, interventional and basic research studies adopting Non‐Invasive Brain Stimulation (NIBS) have significantly risen. Those techniques have been used both in healthy people, to better understand the role of certain brain regions in psychological processes, and in aggressive subjects to improve their symptoms. From an overview of the literature, focusing on the paper that uses transcranial direct current stimulation (tDCS) to reduce aggressiveness, it emerges that tDCS can (i) enhance facial emotion expression recognition, (ii) improve impulses control, and (iii) affect approach/withdrawal motivation. The current work shows the strengths and weaknesses of tDCS intervention on aggressive individuals, suggesting that this instrument could be adopted on violent people, and paves the way for intervention in some applied settings such as prison.

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“…Craving intensity was reduced in the active arm and decision‐making processes were also marginally influenced. Both the sham and active arms demonstrated improvement in affective dysregulation, anxiety and depressive symptoms 5 …”

Section: Transcranial Direct Current Stimulationmentioning

confidence: 98%

Neuromodulation approaches for borderline personality disorder

Yahya

Khawaja

Naguib

2022

Prog Neurol Psychiatry

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Borderline personality disorder (BPD) is a complex and serious mental disorder that has a high suicide rate. There is emerging evidence for the use of nonconvulsive neurostimulation therapies, including transcranial magnetic stimulation (TMS), repetitive TMS (rTMS), and transcranial direct current stimulation (tDCS) in controlling some of the characteristic symptoms. Here the authors summarise the current evidence for the efficacy and tolerability of TMS, rTMS and tDCS in managing symptoms of BPD.

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Change in core symptoms of borderline personality disorder by tDCS: A pilot study

Cited by 19 publications

References 86 publications

Aberrant Structural Connectivity of the Triple Network System in Borderline Personality Disorder Is Associated with Behavioral Dysregulation

Aberrant Structural Connectivity of the Triple Network System in Borderline Personality Disorder Is Associated with Behavioral Dysregulation

Non‐invasive neuromodulation can reduce aggressive behaviors in humans: A critical perspective

Neuromodulation approaches for borderline personality disorder

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