Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study

Singhal, Surbhi; Walter, Louise C.; Smith, Alexander K.; Loh, Kah Poh; Cohen, Harvey Jay; Zeng, Sandra; Shi, Ying; Boscardin, W. John; Presley, Carolyn J.; Williams, Grant R.; Magnuson, Allison; Mohile, Supriya G.; Wong, Melisa L.

doi:10.1016/j.jgo.2022.08.015

Cited by 5 publications

(10 citation statements)

References 57 publications

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“…In this study, 70% of NSCLC survivors had a decline in LSM at 2 months of treatment and at 6 months, only 8% had recovered to baseline, 18% had no recovery, and 37% had additional decline in LSM 28 . Life‐Space Assessment scores were strongly correlated with QOL scores such that those with lower LSA scores (≥ 10‐point decrease) had lower QOL scores 28 …”

Section: Introductionmentioning

confidence: 62%

“…This decline stabilized but did not rebound to their pretreatment baseline by 6 months. 30 Qualitative findings from the study indicated fatigue, anxiety, and dependence in Instrumental Activities of Daily Living were associated with the low LSA score; 28,30 however, that study did not explore the impact of LSM on QOL.…”

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confidence: 94%

“…A recent study indicated that assessing LSM using the LSA was helpful in detecting patients with functional decline and subtle functional changes earlier than other standard functional measures in older adult NSCLC survivors 28 . In this study, 70% of NSCLC survivors had a decline in LSM at 2 months of treatment and at 6 months, only 8% had recovered to baseline, 18% had no recovery, and 37% had additional decline in LSM 28 . Life‐Space Assessment scores were strongly correlated with QOL scores such that those with lower LSA scores (≥ 10‐point decrease) had lower QOL scores 28 …”

Section: Introductionmentioning

confidence: 99%

“…28 Life-Space Assessment scores were strongly correlated with QOL scores such that those with lower LSA scores (≥ 10-point decrease) had lower QOL scores. 28 There is limited information about the consequences of a declining or restricted LSM in older cancer survivors. The forecast of a vastly increased number of older cancer survivors, the high value they place on their QOL, and the potential to modify LSM support the significance of research into the association of LSM and QOL among older cancer survivors.…”

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confidence: 96%

“…[24][25][26] There is a growing body of literature on the impact of LSM in non-cancer serious illnesses, 19,20,21,27 however LSM is understudied in older cancer survivors. [28][29][30] In a prospective longitudinal mixed methods cohort study, Wong et al 30 found that, on average, older non-small cell lung cancer (NSCLC) survivors had low pretreatment LSM (67.1) when compared to LSM population norms for older adults. 31 These NSCLC survivors reported a clinically significant decline of 10.1 32 representing restricted LSM (Life-Space Assessment [LSA] score < 60) after 1 month of treatment.…”

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confidence: 99%

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Restricted life‐space mobility impacts physical but not mental quality of life in older cancer survivors

Taylor,

Bakitas,

Wells

et al. 2023

Cancer Medicine

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BackgroundOlder cancer survivors often value quality of life (QOL) over survival. Life‐space mobility (LSM), defined as the individual's spatial geographic mobility range, is an important QOL indicator in older adults with chronic illnesses; however, this relationship is unexplored in older cancer survivors.MethodsWe examined the longitudinal associations and causal relationships between LSM and QOL in 153 older cancer survivors (≥65 years) from the University of Alabama at Birmingham (UAB) Study of Aging. LSM was assessed using the UAB Life‐Space Assessment‐Composite score (LSA‐C), and QOL was assessed by the SF‐12 Mental Component Score (MCS12) and Physical Component Score (PCS12) at 0 (study entry), 6, 18, 36, 54, and 72 months. We examined the causal relationship between LSM and QOL using a cross‐lagged panel model (CLPM).ResultsThe cohort (n = 153) was 76 years old on average and predominantly White (58%), female (58%), and married (55%). Longitudinal analyses found LSM decreased over time (p < 0.0001), and this decrease was associated with decreased QOL (PCS12, p < 0.0001, MCS12, p < 0.0001). In the CLPM causal analysis, lower LSM resulted in worse PCS12 (p < 0.001), but not worse MSC12.ConclusionsRestricted LSM resulted in worse physical QOL over 72 months in a sample of 153 older cancer survivors. Developing and evaluating interventions to preserve greater LSM could be a promising approach to improving QOL.

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Section: Introductionmentioning

confidence: 62%

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confidence: 94%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 96%

mentioning

confidence: 99%

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Restricted life‐space mobility impacts physical but not mental quality of life in older cancer survivors

Taylor,

Bakitas,

Wells

et al. 2023

Cancer Medicine

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Survivorship outcomes in patients treated with immune checkpoint inhibitors: a scoping review

Güven,

Thong,

Arndt

2024

J Cancer Surviv

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Background Immune checkpoint inhibitors (ICIs) have become a central part of cancer care. However, the survivorship outcomes in patients treated with ICIs are understudied. Therefore, we conducted a scoping review to evaluate the current status of the field and to establish research gaps regarding survivorship outcomes with ICIs in real-life cohorts. Methods We used the Web of Science, PubMed, and Embase databases to systematically filter published studies with real-life cohorts from January 1, 2010, until October 19, 2022. Studies evaluating at least one survivorship outcome in ICI-treated patients were included. Results A total of 39 papers were included. Quality of life (QoL) (n = 23), toxicity burden (n = 16), and psychosocial issues (n = 9) were the most frequently evaluated survivorship outcomes. Anti-PD-1/PD-L1 monotherapy and a response to treatment were associated with better QoL. In addition, the ICIs were associated with grade 3 or higher immune-related adverse events (irAEs) in 10–15% and late/long-term irAEs in 20–30% of the survivors. Regarding psychosocial problems, over 30% of survivors showed evidence of anxiety and depression, and 30–40% of survivors reported neurocognitive impairments. Conclusion The survivors treated with ICIs have impairments in most survivorship domains. Further research is needed to gather data on the understudied survivorship outcomes like late and long-term effects, fertility, financial toxicity, and return to work in survivors treated with ICIs. Implications for Cancer Survivors Available evidence demonstrates that a significant portion of survivors treated with ICIs have a significant toxicity burden, lower QoL than the general population, and a high rate of psychosocial problems.

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Not just a number, the benefit of mixed methods studies: An editorial

VanderWalde¹

2023

Journal of Geriatric Oncology

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Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study

Cited by 5 publications

References 57 publications

Restricted life‐space mobility impacts physical but not mental quality of life in older cancer survivors

Restricted life‐space mobility impacts physical but not mental quality of life in older cancer survivors

Survivorship outcomes in patients treated with immune checkpoint inhibitors: a scoping review

Not just a number, the benefit of mixed methods studies: An editorial

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