Change in fractional anisotropy during treatment of diabetic ketoacidosis in children

Dervan, Leslie A.; Poliakov, Andrew; Friedman, Seth D.; Shaw, Dennis; Pihoker, Catherine; Roberts, Joan; Richards, Todd L.; Marro, Kenneth I.; Vavilala, Monica S.

doi:10.1038/pr.2013.168

Cited by 11 publications

(19 citation statements)

References 22 publications

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“…The uncinate fasciculus control emotions[34]. The degree of change in DTI metrics were consistent with the degree of improvement seen in some other medical conditions[22, 35]. …”

Section: Discussionsupporting

confidence: 56%

Cognitive Function and White Matter Changes Associated with Renal Transplantation

Gupta

Lepping

et al. 2016

Am J Nephrol

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Background: End-stage renal disease (ESRD) is a disease with an aging population and a high prevalence of cognitive impairment affecting quality of life, health care costs and mortality. Structural changes in the brain with decreased white matter integrity have been observed in ESRD. Understanding the changes in cognition and associated changes in brain structure after renal transplantation can help define the mechanisms underlying cognitive impairment in ESRD. Methods: We conducted a prospective, observational cohort study in ESRD patients listed for renal transplantation and followed them post-transplantation. We assessed their cognitive function with a battery of neuropsychological tests and brain white matter integrity with diffusion tensor imaging (DTI) both before transplant and 3 months after transplant. Results: Eleven patients, aged 56.5 ± 10.7 years, completed the study. Cognitive measures of memory and executive function improved after the transplant, specifically on tests of logical memory I (p = 0.004), logical memory II (p = 0.003) and digit symbol (p < 0.0001). DTI metrics also improved post the transplant with an increase in fractional anisotropy (p = 0.01) and decrease in mean diffusivity (p = 0.004). These changes were more prominent in tracts associated with memory and executive function. Conclusions: Cognitive function, particularly memory and executive function, improve post the transplant with concurrent improvements in white matter integrity in tracts associated with memory and executive function. These data suggest that abnormalities in cognition and brain structure seen in the ESRD population are at least partially reversible.

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“…The uncinate fasciculus control emotions[34]. The degree of change in DTI metrics were consistent with the degree of improvement seen in some other medical conditions[22, 35]. …”

Section: Discussionsupporting

confidence: 56%

Cognitive Function and White Matter Changes Associated with Renal Transplantation

Gupta

Lepping

et al. 2016

Am J Nephrol

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“…Recently, shorter time frames are becoming relevant as studies have reported rapid changes in anisotropy following post-acute pathological changes in brain tissue or after treatments targeting specific conditions. 23–26 …”

Section: Discussionmentioning

confidence: 99%

Correlation of Fractional Anisotropy With Motor Recovery in Patients With Stroke After Postacute Rehabilitation

Wen

Alshikho

Wang

et al. 2016

Archives of Physical Medicine and Rehabilitation

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Objective To investigate the relationship between fractional anisotropy (FA), a suggested biomarker for tissue integrity, and motor recovery in stroke patients following post-acute rehabilitation. Design Retrospective study. Setting Acute rehabilitation hospital. Participants 43 subjects, 28 diagnosed with ischemic stroke, and 15 diagnosed with hemorrhagic stroke. The average age for subjects was (68±14 years). Interventions MRI and Diffusion Tensor Imaging (DTI) were conducted on all patients. Main Outcome Measure(s) This is a retrospective study. The admission and discharge motor sub-scores of the Functional Independence Measure (FIM) were obtained from medical records, and relative gain was calculated using the Montebello Rehabilitation Factor Score (MRFS). K-means cluster analysis (K=3) using both MRFS and gain of FIM motor sub-score (ΔFIM) was performed. ANOVA test was used to determine the difference in FA among the clusters. Spearman analysis was conducted to examine the relationship between FA, ΔFIM, and MRFS in each cluster. Results FA was significantly higher in the clusters of good and moderate recovery in the corticospinal tract (CST), peduncle, and posterior limb of the internal capsule (PLIC) bilaterally (all P<0.05) compared to the poor recovery group. Significant positive correlations were observed in multiple regions along CST between FA, ΔFIM, and MRFS in the clusters of good and moderate recovery, but not in the poor recovery group. Conclusion Our results showed an association between FA values within the corticospinal tract and motor recovery in stroke patients undergoing post-acute rehabilitation. This finding may help to identify novel targets for new interventions to promote stroke recovery.

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“…Particularly, given some location affected by edema immediately after injury, one might expect FA in such a region to decrease at first [28], and then gradually to increase as hematoma volume decreases. This is because the typical lesion pattern in ICH consists of a hemorrhagic core surrounded by non-hemorrhagic edema.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal quantification and visualization of intracerebral haemorrhage using multimodal magnetic resonance and diffusion tensor imaging

et al. 2014

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Objective To demonstrate a set of approaches using diffusion tensor imaging (DTI) tractography whereby pathology-affected white matter (WM) fibers in patients with intracerebral hemorrhage (ICH) can be selectively visualized. Methods Using structural neuroimaging and DTI volumes acquired longitudinally from three representative ICH patients, the spatial configuration of ICH-related trauma is delineated and the WM fiber bundles intersecting each ICH lesion are identified and visualized. Both the extent of ICH lesions as well as the proportion of WM fibers intersecting the ICH pathology are quantified and compared across subjects. Results Our method successfully demonstrates longitudinal volumetric differences in ICH lesion load and differences across time in percentage of fibers which intersect the primary injury. Conclusions Because neurological conditions such as intracerebral hemorrhage (ICH) frequently exhibit pathology-related effects which lead to the exertion of mechanical pressure upon surrounding tissues, and thereby to the deformation and/or displacement of WM fibers, DTI fiber tractography is highly suitable for assessing longitudinal changes in WM fiber integrity and mechanical displacement.

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Change in fractional anisotropy during treatment of diabetic ketoacidosis in children

Cited by 11 publications

References 22 publications

Cognitive Function and White Matter Changes Associated with Renal Transplantation

Cognitive Function and White Matter Changes Associated with Renal Transplantation

Correlation of Fractional Anisotropy With Motor Recovery in Patients With Stroke After Postacute Rehabilitation

Longitudinal quantification and visualization of intracerebral haemorrhage using multimodal magnetic resonance and diffusion tensor imaging

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