Change in Intraocular Pressure in the Fellow Eye After Glaucoma Surgery in 1 Eye

Kaushik, Sushmita; Agarwal, Aniruddha; Kaur, Savleen; Lomi, Neiwete; Raj, Srishti; Pandav, Surinder Singh

doi:10.1097/ijg.0000000000000217

Cited by 13 publications

(22 citation statements)

References 18 publications

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“…In our study, we found that the mean IOP for the contralateral control eyes significantly increased when compared to its mean baseline IOP value in the Group 1 primates, although the mean IOPs in the OHT period between months 2-7 did not exceed 20 mmHg (Table 1). This finding seems to corroborate those of previous studies [33][34][35][36] . A consensual IOP rise has been frequently reported in both experimental and clinical glaucoma studies [33][34][35]37 .…”

Section: Discussionsupporting

confidence: 93%

“…This finding seems to corroborate those of previous studies [33][34][35][36] . A consensual IOP rise has been frequently reported in both experimental and clinical glaucoma studies [33][34][35]37 . Although the exact mechanism for this consensual IOP effect has not been elucidated, postulated mechanisms include: glaucoma drug effects 36 ; activation of sympathetic neural signals in the anterior segment that might increase the aqueous outflow 34 ; anterior chamber cannulation that activates microglia 37 ; and prostaglandin release that might exert a minor effect on the trabecular meshwork and thus cause a minor IOP elevation 35,37 .…”

Section: Discussionsupporting

confidence: 93%

“…Others have also suggested that the contralateral eye might not be an ideal control for normotension 7,31,32 . Previous data have shown that the contralateral eyes can be affected when the IOP is elevated in the study eyes [33][34][35][36] . Some of these changes include microglial activation 37 , transient disc swelling 7 and longitudinal loss of multifocal electroretinogram signals 32 .…”

Section: Discussionmentioning

confidence: 90%

“…A consensual IOP rise has been frequently reported in both experimental and clinical glaucoma studies [33][34][35]37 . Although the exact mechanism for this consensual IOP effect has not been elucidated, postulated mechanisms include: glaucoma drug effects 36 ; activation of sympathetic neural signals in the anterior segment that might increase the aqueous outflow 34 ; anterior chamber cannulation that activates microglia 37 ; and prostaglandin release that might exert a minor effect on the trabecular meshwork and thus cause a minor IOP elevation 35,37 . In our study, we considered that sympathetic neural signals, microglial activation and prostaglandin release might be the most relevant factors that could have caused the consensual IOP rise in our Group 1 primates.…”

Section: Discussionmentioning

confidence: 92%

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Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

Chan

Tun

Allen

et al. 2020

Sci Rep

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In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus primates (10 unilateral; 6 bilateral) and assessed the structural changes of the ONH longitudinally to observe early changes. Elevated intraocular pressure (IOP) in OHT eyes was maintained for 7 months and serial OCT measurements were performed during this period. The mean IOP was significantly elevated in OHT eyes when compared to baseline and compared to the control eyes. Thinner MRW and deeper LCD values from baseline were observed in OHT eyes with the greatest changes seen between month 1 and month 2 of OHT. Both the mean and maximum IOP values were significant predictors of MRW and LCD changes, although the maximum IOP was a slightly better predictor. We believe that this model could be useful to study IOP-induced early ONH structural damage which is important for understanding glaucoma pathogenesis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 92%

See 2 more Smart Citations

Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

Chan

Tun

Allen

et al. 2020

Sci Rep

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“… 16 – 20 However, choroidal expansion mechanism seems to be more effective in angle closure eyes than in open-angle eyes or healthy eyes and this was quantified with optical coherence tomography studies. 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test

Özyol

Baldemir

2016

OPTH

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AimTo evaluate the clinical applicability of the water-drinking test in treatment-naive primary open-angle glaucoma patients.MethodsTwenty newly diagnosed primary open-angle glaucoma patients and 20 healthy controls were enrolled in this prospective study. The water-drinking test was performed at baseline and 6 weeks and 3 months after prostaglandin analog treatment. Peak and fluctuation of intraocular pressure (IOP) measurements obtained with the water-drinking test during follow-up were analyzed. Analysis of variance for repeated measures and paired and unpaired t-tests were used for statistical analysis.ResultsThe mean baseline IOP values in patients with primary open-angle glaucoma were 25.1±4.6 mmHg before prostaglandin analog treatment, 19.8±3.7 mmHg at week 6, and 17.9±2.2 mmHg at month 3 after treatment. The difference in mean baseline IOP of the water-drinking tests was statistically significant (P<0.001). At 6 weeks of prostaglandin analog treatment, two patients had high peak and fluctuation of IOP measurements despite a reduction in baseline IOP. After modifying treatment, patients had lower peak and fluctuation of IOP values at month 3 of the study.ConclusionPeak and fluctuation of IOP in response to the water-drinking test were lower with prostaglandin analogs compared with before medication. The water-drinking test can represent an additional benefit in the management of glaucoma patients, especially by detecting higher peak and fluctuation of IOP values despite a reduced mean IOP. Therefore, it could be helpful as a supplementary method in monitoring IOP in the clinical practice.

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Inter-eye relationship of intraocular pressure change after unilateral trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation

Aghayeva

Chronopoulos

Schuster

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose This study assesses short-term intraocular pressure (IOP) change in the fellow eye of glaucoma patients after mitomycin C–augmented trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation in the treated eye. Materials and methods Retrospective chart review of 235 glaucoma patients (235 eyes) was performed. Patients underwent initial trabeculectomy (187 patients), filtering canaloplasty (25 patients), or PreserFlo™ microshunt implantation (23 patients) in one eye, while the fellow eye was naïve to any previous glaucoma surgery. IOP was evaluated before and on the 1st and 2nd days and at 1 week after surgery. Main outcome measure was IOP change in the fellow eye. Secondary outcomes were proportion of clinically significant IOP elevation in the fellow eye and evaluation of potential risk factors associated with postoperative IOP fluctuation. Results IOP in the fellow eye at 1 week after trabeculectomy was statistically significantly lower than preoperatively (p < 0.0001), while the IOP did not change significantly in the fellow eyes in filtering canaloplasty or PreserFlo groups. The higher the preoperative IOP was in the fellow eye, the larger was the intraocular pressure-lowering effect at 1 week after trabeculectomy (p < 0.0001). A clinically significant IOP elevation was noted in 14.2%, 9.5%, and 5% of fellow eyes after trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation, respectively. Conclusions This study shows an IOP-lowering effect in the fellow eye of glaucoma patients after trabeculectomy. Significant IOP rise might occur in the fellow eye of some glaucoma patients after different types of glaucoma surgery.

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Change in Intraocular Pressure in the Fellow Eye After Glaucoma Surgery in 1 Eye

Abstract: Glaucoma surgery in eye is associated with a rise in IOP of the fellow eye, regardless of whether the fellow eye is normal or glaucomatous, or had been previously treated with acetazolamide. Fellow eyes of all patients scheduled for glaucoma surgery require careful monitoring of the IOP.

Cited by 13 publications

References 18 publications

Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

Intraocular pressure dynamics with prostaglandin analogs: a clinical application of water-drinking test

Inter-eye relationship of intraocular pressure change after unilateral trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation

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