Change in retinal and choroidal microvascular structures after rhegmatogenous retinal detachment surgery and effects on visual recovery

Yaprak, Aslı Çetinkaya; Küçük, Mehmet Fatih; Yaprak, Lütfiye; Erol, Muhammet Kazım

doi:10.1016/j.jfo.2020.11.027

Cited by 8 publications

(8 citation statements)

References 33 publications

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“…Our results are in line with other researchers who have noted a reduction in VD, mainly in the DCP, and an expansion of the FAZ area [31,34,36]. Çetinkaya-Yaprak et al [37] also demonstrated an increase in the FAZ area and a decrease in retinochoroidal flow within the initial three months post-surgery.…”

Section: Discussionsupporting

confidence: 93%

“…While it was conducted at a single center with a relatively modest sample size and a brief follow-up period, mirroring the scope of many surgical studies in this domain, it is important to highlight that we examined 44 eyes affected by macula off RRD. This sample size surpasses that of comparable studies [31][32][33][34][35][36][37][38][39]. Inherent to the studied pathology, the inability to determine the preoperative OCTA parameters in eyes with macula off RRD limited the metrics comparison after surgery.…”

Section: Discussionmentioning

confidence: 94%

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Quantitative Microvascular Change Analysis Using a Semi-Automated Software in Macula-off Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography

Díaz-Aljaro,

Zarranz-Ventura,

Broc-Iturralde

et al. 2024

JCM

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Objective: To analyze the performance of custom semi-automated software for quantitative analysis of retinal capillaries in eyes with macula-off rhegmatogenous retinal detachment (RRD) and the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: A prospective, observational, and single-center study was conducted on consecutive patients who underwent 25G pars-plana vitrectomy for primary uncomplicated macula-off RRD. Optical coherence tomography angiography (OCTA) was performed in the fellow and RRD eyes before surgery and in months 1, 3, and 6 after surgery. The preoperative values of the fellow eyes were used as surrogates of macula-off ones. The primary endpoints were the mean vessel diameter index (VDI); vessel area density (VAD); and vessel skeleton density (VSD) at month 6. Results: Forty-four eyes (44 patients) were included in the study. Considering the fellow eyes as a surrogate of preoperative values of macula-off eyes, VDI in superficial (SCP) and deep (DCP) capillary plexuses was significantly reduced at month 6 (p = 0.0087 and p = 0.0402, respectively); whereas VSD in SCP increased significantly from preoperative values (p = 0.0278). OCTA built-in software parameters were significantly reduced from month 1 to month 6 in both SCP and DCP (p values ranged between 0.0235 and <0.0001). At month 6, 25 (56.8%) eyes achieved a best-corrected visual acuity BCVA ≥ 0.3 (LogMAR). The greater the preoperative BCVA, the greater the probability of achieving good visual outcomes (Odds ratio: 11.06; p = 0.0037). However, none of the OCTA parameters were associated with the probability of achieving a BCVA improvement ≥ 0.3. Conclusions: Quantitative evaluation of capillary density and morphology through OCTA and semi-automated software represents a valuable tool for clinical assessment and managing the disease comprehensively.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Quantitative Microvascular Change Analysis Using a Semi-Automated Software in Macula-off Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography

Díaz-Aljaro,

Zarranz-Ventura,

Broc-Iturralde

et al. 2024

JCM

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“…A fair number of studies with a follow-up no longer than 8 months were investigated. Reduction of VD in retinal capillary plexuses in comparison to fellow eyes at post-operative follow-up was usually reported in literature, with more significant evidence in Macula-OFF condition [ 11 , 21 , 22 , 23 , 24 , 25 ]. In contrast, Hong et al found that the SCP and DCP VD in the operated eyes did not differ significantly from the fellow eyes for both the Macula-ON and Macula-OFF groups, at 6 months follow-up [ 26 ].…”

Section: Discussionmentioning

confidence: 72%

“…In contrast, Hong et al found that the SCP and DCP VD in the operated eyes did not differ significantly from the fellow eyes for both the Macula-ON and Macula-OFF groups, at 6 months follow-up [ 26 ]. In some cases, a progressive increase in VD has been reported over the follow-up time [ 21 , 27 ]; on the contrary Jiang J et al, in their retrospective study, found a decreased VD at 16 wks post-operatively, after an initial increase during the first 12 wks. Unfortunately, our study could not evaluate this aspect as a single long-term follow-up was performed [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Macular Vascular Changes after Primary Rhegmatogenous Retinal Detachment Surgery Resolved with Different Tamponade or Different Surgical Techniques

Gironi

D’Aloisio

Verdina

et al. 2022

Life

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Background: The aim of this study was to assess long-term macular vascular changes and their correlation with functional recovery in patients successfully treated for Macula-ON and Macula-OFF rhegmatogenous retinal detachment (RRD). Methods: This retrospective observational study included 82 eyes of 82 patients who received primary successful retinal detachment surgery, 33 Macula-ON and 49 Macula-OFF. Superficial and deep capillary plexuses (SCP and DCP) were evaluated by optical coherence tomography angiography (OCTA), and were correlated with visual acuity (VA), surgical technique and tamponade at 12 months after surgery. The fellow eyes were used as controls. Results: At 12-month follow-up, there was a significant decrease in the vessel density (VD) in the SCP in the operated eyes compared to control eyes (p < 0.05) in both the Macula-ON and Macula-OFF groups. Vessel length density (VLD) decrease in SCP was more extended in the Macula-OFF group. No difference in the DCP perfusion parameters was found, compared to controls. Subgroup analysis dependent on the type of surgery or tamponade showed no significant differences of VD and VLD. An inverse correlation was found between the SCP VD and the duration of silicone oil (SO) tamponade (p = 0.039). A significant correlation was observed between parafoveal SCP VD and final best corrected visual acuity (BCVA) (p = 0.028). The multivariate linear regression analysis showed that only the type of tamponade was significantly correlated with the final BCVA in the Macula-ON group (p = 0.004). Conclusions: Our study described long-term perfusion changes in RRD after surgery, with lower SCP VD and VLD in the operated eyes compared to the fellow ones, not influenced by type of surgery or tamponade. The choice of tamponade and SO removal timing may affect functional outcomes, especially in Macula-ON RRD. In conclusion, such functional and perfusion changes can be considered biomarkers that highlight the relevance of careful management of this sight-threatening disease.

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“…They suggested a rehabilitation curve of the different retinal plexuses, with gradual macular vascularization recovery with the attached and flattened retina. Çetinkaya-Yaprak et al, also in the first 3 months after surgery, demonstrated an increase in the FAZ area and a diminished retinochoroidal flow [34].…”

Section: Discussionmentioning

confidence: 89%

Long‐term follow up of macular perfusion evaluated by optical coherence tomography angiography after rhegmatogenous retinal detachment surgery

Pinilla

Bartolomé

Díaz‐Barreda

et al. 2022

Acta Ophthalmologica

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Change in retinal and choroidal microvascular structures after rhegmatogenous retinal detachment surgery and effects on visual recovery

Cited by 8 publications

References 33 publications

Quantitative Microvascular Change Analysis Using a Semi-Automated Software in Macula-off Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography

Quantitative Microvascular Change Analysis Using a Semi-Automated Software in Macula-off Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography

Long-Term Macular Vascular Changes after Primary Rhegmatogenous Retinal Detachment Surgery Resolved with Different Tamponade or Different Surgical Techniques

Long‐term follow up of macular perfusion evaluated by optical coherence tomography angiography after rhegmatogenous retinal detachment surgery

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