Change in shape of the aging human crystalline lens with accommodation

Dubbelman, M.; Heijde, G.L. van der; Weeber, Henk A

doi:10.1016/j.visres.2004.07.032

Cited by 269 publications

(330 citation statements)

References 35 publications

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“…Cycloplegia is reported to induce significant decreases in the lens thickness and backward movement of the lens. 24 Dubblman et al 25,26 used Scheimpflug images to show that accommodation induces hypertrophy of the central portion of the lens. The authors reported that the radii of curvature of the anterior and posterior surfaces of the crystalline lens affected the change in spherical aberration, resulting in a late central wavefront.…”

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confidence: 99%

Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children

Hiraoka

Nakamura

Ogata

et al. 2014

Eye

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Purpose To investigate the influence of cycloplegia with topical cyclopentolate on wavefront aberrations in myopic children. Design This is a prospective, comparative study. Methods Twenty-eight myopic children with a mean age of 7.25±2.55 were enrolled in this study. We evaluated refraction and wavefront aberrations before and after cycloplegia with 1% cyclopentolate hydrochloride. Ocular and corneal aberrations were simultaneously measured and compared with each other. Individual Zernike components were also analyzed up to the sixth order. All these parameters were compared before and after cycloplegia. Results Ocular higher-order aberrations (HOAs) significantly increased after cycloplegia (P ¼ 0.012 for spherical-like and P ¼ 0.015 for total HOAs). Corneal HOAs did not change after cycloplegia. When corneal and ocular HOAs were compared, the ocular HOAs were significantly smaller than the corneal HOAs in spherical-like aberrations (Po0.001) and total HOAs (P ¼ 0.006). As for individual Zernike components, ocular aberration generally showed smaller or equivalent values in comparison with corneal aberration. In addition, each Zernike component showed a large standard deviation. Conclusions Internal optics compensates for corneal HOAs in myopic children, and paralysis of tonic accommodation with cyclopentolate considerably affects ocular HOAs. However, inter-individual variation in each Zernike component is quite large in myopic children.

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confidence: 99%

Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children

Hiraoka

Nakamura

Ogata

et al. 2014

Eye

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“…Most data and models come from in vitro studies, and only a reduced number of techniques such as Scheimplug imaging [56][57][58] permit to obtain one-dimensional (1D) profiles of the lens surfaces. Data from in vitro studies are scarce and limited to 1D profiles.…”

Section: Optics Of the Crystalline Lensmentioning

confidence: 99%

“…Most authors assume that the shape of the in vitro lens corresponds to a fully accommodated state. Dubbelman and co-workers have reported an empirical model of the changes of the lens surfaces with age and accommodation, 58 shown in table 1.…”

Section: Optics Of the Crystalline Lensmentioning

confidence: 99%

The Optical Design of the Human Eye: a Critical Review

Navarro

2009

Journal of Optometry

100

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Cornea, lens and eye models are analyzed and compared to experimental findings to assess properties and eventually unveil optical design principles involved in the structure and function of the optical system of the eye. Models and data often show good match but also some paradoxes. The optical design seems to correspond to a wide angle lens. Compared to conventional optical systems, the eye presents a poor optical quality on axis, but a relatively good quality off-axis, thus yielding higher homogeneity for a wide visual field. This seems the result of an intriguing combination of the symmetry design principle with a total lack of rotational symmetry, decentrations and misalignments of the optical surfaces (J Optom 2009;2:3-18 ©2009 Spanish Council of Optometry) KEY WORDS: human eye's optical design; eye models; design principles; ocular aberrations; optical quality of the eye. RESUMENEn este trabajo, los modelos de córnea, de cristalino y de ojo se analizan y se comparan con los datos experimentales para evaluar las propiedades y, eventualmente, para desvelar los principios del diseño óptico que afectan a la estructura y al funcionamiento del sistema óptico del ojo humano. A menudo encontramos una coincidencia razonable entre los modelos y los datos experimentales, pero también se ponen de manifiesto algunas paradojas. El diseño óptico parece corresponderse con el de un gran angular. En comparación con los sistemas ópticos convencionales, el ojo tiene una mala calidad óptica en eje pero, por el contrario, presenta una calidad relativamente buena fuera de eje, proporcionando así una gran homogeneidad a una amplia extensión del campo visual. Este hecho parece ser el resultado de una curiosa combinación del principio de diseño simétrico con una total ausencia de simetría de rotación, con descentramientos y con una deficiente alineación de las superficies ópticas. (J Optom 2009;2:3-18 ©2009 Consejo General de Colegios de Ópticos-Optometristas de España) PALABRAS CLAVE: diseño óptico del ojo humano; modelos de ojo; principios de diseño; aberraciones oculares; calidad óptica del ojo.

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“…It adopts a more rounded shape, with both surfaces (but particularly the anterior surface), becoming more curved. The lens reduces in diameter, and becomes thicker axially accompanied by a similar reduction in anterior chamber depth and a small reduction in vitreous depth [2,3]. Strenk et al reported increase in cross-sectional area of the anterior portion of the lens with accommodation [4], but others had reported small decreases in cross-sectional area with accommodation [5,6].…”

Section: Introductionmentioning

confidence: 99%

Change in human lens dimensions, lens refractive index distribution and ciliary body ring diameter with accommodation

Khan

Pope

Verkicharla

et al. 2018

Biomed. Opt. Express

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Abstract:We investigated changes in ciliary body ring diameter, lens dimensions and lens refractive index distributions with accommodation in young adults. A 3T clinical magnetic resonance imaging scanner imaged right eyes of 38 18-29 year old participants using a multiple spin echo sequence to determine accommodation-induced changes along lens axial and equatorial directions. Accommodation stimuli were approximately 1 D and 5 D. With accommodation, ciliary body ring diameter, and equatorial lens diameter decreased (-0.43 ± 0.31 mm and -0.30 ± 0.23 mm, respectively), and axial lens thickness increased ( + 0.34 ± 0.16 mm). Lens shape changes cause redistribution of the lens internal structure, leading to change in refractive index distribution profiles. With accommodation, in the axial direction refractive index profiles became flatter in the center and steeper near the periphery of the lens, while in the equatorial direction they became steeper in the center and flatter in the periphery. The results suggest that the anatomical accuracy of lens optical models can be improved by accounting for changes in the refractive index profile during accommodation.

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Change in shape of the aging human crystalline lens with accommodation

Cited by 269 publications

References 35 publications

Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children

Influence of cycloplegia with topical cyclopentolate on higher-order aberrations in myopic children

The Optical Design of the Human Eye: a Critical Review

Change in human lens dimensions, lens refractive index distribution and ciliary body ring diameter with accommodation

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