Change in skeletal muscle mass is associated with hepatic steatosis in nonalcoholic fatty liver disease

Jo, Ik Hyun; Song, Do Seon; Chang, U Im; Yang, Jin Mo

doi:10.1038/s41598-023-34263-z

Cited by 9 publications

(2 citation statements)

References 49 publications

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“…Several studies have indicated that as the BMI, AC increases, there is a significant increase in skeletal muscle weight, skeletal muscle index, and limb fat. Furthermore, a higher muscle mass seems to be a negative correlation with the occurrence of NAFLD (26)(27)(28).…”

Section: Discussionmentioning

confidence: 98%

Association between the arm circumference and non-alcoholic fatty liver disease in American children and adolescence: a population-based analysis

Weng,

Xu,

Yang

2024

Front. Public Health

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BackgroundThe arm circumference (AC) has been used as an important tool to access the risk of non-alcoholic fatty liver disease (NAFLD) in adults. However, the association between AC and NAFLD in children and adolescence remains unclear. This study aims to explore the relationship between AC and NAFLD in American children and adolescence.Methods2017–2020 National Health and Nutrition Examination Survey (NHANES) was used to carry out the cross-sectional study. The association between AC and the risk of NAFLD, and liver steatosis was analyzed using weighted multivariable logistic regression and multivariate linear regression. Additionally, a two-part linear regression model was used to identify threshold effects in this study. Subgroup analysis, interaction tests and receiver operating characteristic (ROC) curve analysis were also carried out.ResultsA total of 1,559 children and adolescence aged 12–18 years old were included, and the prevalence of NAFLD was 27.3%. AC was positively correlated with the risk of NAFLD (OR = 1.25, 95% CI: 1.19, 1.32) and liver steatosis (β = 4.41, 95% CI: 3.72, 5.09). Subgroup analysis stratified by age and race showed a consistent positive correlation. A non-linear relationship and saturation effect between AC and NAFLD risk were identified, with an S shaped curve and an inflection point at 34.5 cm. Area under the ROC of AC to NAFLD was 0.812, with the sensitivity of 67.6%, the specificity of 83.8% and the cutoff value of 31.7 cm.ConclusionOur study shows that AC is independently correlated with an increased risk of NAFLD and the severity of liver steatosis in American children and adolescence.

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Section: Discussionmentioning

confidence: 98%

Association between the arm circumference and non-alcoholic fatty liver disease in American children and adolescence: a population-based analysis

Weng,

Xu,

Yang

2024

Front. Public Health

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“…One group measured the appendicular skeletal muscle mass in a biopsy-proven MASLD cohort and found that the prevalence of significant fibrosis (> or = F2) was higher in patients with sarcopenia than in those without[ 12 ]. Patients with sarcopenia at baseline have a higher rate of hepatic fibrosis progression[ 13 ]. Conversely, an increase in skeletal muscle mass has been shown to exert a positive effect in slowing down the progression of MASLD[ 14 ].…”

Section: Sarcopenia As a Risk Factor For Masldmentioning

confidence: 99%

Sarcopenia and metabolic dysfunction associated steatotic liver disease: Time to address both

Wong,

Yuan

2024

World J Hepatol

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Sarcopenia and metabolic dysfunction associated steatotic liver disease (MASLD) are closely intertwined. Sarcopenia, traditionally a disease of the older adult and chronic disease population, has been closely studied as one of the pathophysiologic conditions at play in the development of MASLD. They share similar risk factors of insulin resistance and physical inactivity. Given similar pathophysiology along the liver-muscle axis, sarcopenia has been studied as a risk factor for MASLD, and vice versa. Current research suggests a bidirectional relationship. Given the chronicity of MASLD as a chronic inflammatory liver disease, it can break down muscle mass and lead to sarcopenia, while sarcopenia promotes intramuscular lipid accumulation that releases cytokines that can aggravate inflammation in the liver. However, for the longest time, a lack of consensus definition for MASLD and sarcopenia made it difficult to study their relationship and outcomes. A recent nomenclature update to diagnosing MASLD has made it easier for researchers to identify cohorts for study. However, no gold standard technique to measure muscle mass or consensus sarcopenia definition has been identified yet. Future studies are needed to reach a consensus and reduce diagnostic variation. With similar pathophysiology and shared risk factors between the two diseases, future research may also identify potential therapeutic targets along the liver-muscle axis that would benefit both sarcopenia and MASLD in order to maximize their outcomes.

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Least significant change with repeat bioelectrical impedance analysis measurements in children with metabolic dysfunction–associated steatotic liver disease: A descriptive cohort study

Speakman,

Hitchcock,

Romantic

et al. 2024

J Parenter Enteral Nutr

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BackgroundBioelectrical impedance is used clinically to assess body composition. To determine true (rather than chance/measurement error) change in bioelectrical impedance analysis measurements over time, it is necessary to know their least significant change. Least significant change represents values exceeding the 95% prediction interval of the precision error of repeat measurements. The least significant change of repeat bioelectrical impedance analysis measurements in children with obesity and metabolic dysfunction–associated steatotic liver disease is currently unknown.MethodsThis is a prospective, single‐center, descriptive cohort study in youth 6–20 years of age with obesity and metabolic dysfunction–associated steatotic liver disease. Two same‐day bioelectrical impedance analysis measurements were performed on a multifrequency, octopolar device (InBody 370). Fat mass and fat‐free mass were adjusted for age using respective indices (dividing by height squared). Fasting status was determined by patient report. Descriptive statistics (medians with interquartile ranges and means with standard deviations and proportions) were used; the least significant change between repeat measurements with precision interval was calculated.ResultsWe recruited 43 patients (81% male; 33% Hispanic; median age: 14 years [interquartile range: 11–16]; median body mass index z score: 2.31 [interquartile range: 2.84–2.65]). A total of 60% were fasting, for a median of 12 h. The least significant change of fat mass index was 0.5 (precision interval: −0.4 to 0.5) kg/m2, fat‐free mass index was 0.3 (precision interval: −0.3 to 0.3) kg/m2, and body fat percent was 1.5% (precision interval: −1.3 to 1.50). Fasting status affected least significant change measurements.ConclusionIn youth with obesity and metabolic dysfunction–associated steatotic liver disease, repeat bioelectrical impedance analysis measurements beyond least significant change and precision interval determined in this study likely represent true changes in body composition over time, vs measurement error.

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Change in skeletal muscle mass is associated with hepatic steatosis in nonalcoholic fatty liver disease

Cited by 9 publications

References 49 publications

Association between the arm circumference and non-alcoholic fatty liver disease in American children and adolescence: a population-based analysis

Association between the arm circumference and non-alcoholic fatty liver disease in American children and adolescence: a population-based analysis

Sarcopenia and metabolic dysfunction associated steatotic liver disease: Time to address both

Least significant change with repeat bioelectrical impedance analysis measurements in children with metabolic dysfunction–associated steatotic liver disease: A descriptive cohort study

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