Change in T2-Fat Saturation MRI Correlates With Outcome in Cervical Cancer Patients

Daniel, J.; Zhu, Jihong; Grigsby, Perry W.

doi:10.1016/j.ijrobp.2010.10.008

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…Chung et al reported that cervical adenocarcinoma showed a higher signal intensity than CSCC on T 2 images . Ma et al found that longitudinal changes in T 2 ‐FS tumor intensity during chemoradiation correlated with disease‐free survival in cervical cancer patients . Our results showed that radiomics analysis of the signal intensity of both T 2 and T 2 ‐FS images presented discriminative values in differentiating the pathological characteristics of CSCCs, suggesting their potential use in the characterization of tumor features.…”

Section: Discussionsupporting

confidence: 54%

Radiomics Analysis of Multiparametric MRI Evaluates the Pathological Features of Cervical Squamous Cell Carcinoma

Shi

Dou

et al. 2018

Magnetic Resonance Imaging

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Section: Discussionsupporting

confidence: 54%

Radiomics Analysis of Multiparametric MRI Evaluates the Pathological Features of Cervical Squamous Cell Carcinoma

Shi

Dou

et al. 2018

Magnetic Resonance Imaging

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“…Magnetic resonance imaging (MRI) also is used for the evaluation of cervical cancer. T2-weighted MRI provides improved tumor delineation for early-stage disease compared to computed tomography (CT) (4), although the tumor volume measured by T2-weighted MRI has not been evaluated for correlation with the metabolically active volume measured by FDG-PET (5).…”

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confidence: 99%

Tumor volume and subvolume concordance between FDG‐PET/CT and diffusion‐weighted MRI for squamous cell carcinoma of the cervix

Olsen

Esthappan

DeWees

et al. 2012

Magnetic Resonance Imaging

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Purpose To compare FDG-PET/CT and MRI imaging for evaluating patients with cervical cancer. We compared tumor characteristics on FDG-PET and apparent diffusion coefficient (ADC) maps on diffusion-weighted MRI (DWI) to evaluate concordance of two functional imaging techniques. Materials and Methods Twenty women with cervical cancer underwent pre-treatment FDG-PETCT and pelvic MRI. Images were rigidly fused by pelvic anatomy using co-registration software. Tumor contours on PET images were generated by auto-segmentation of the region containing at least 40% of the maximum standardized uptake value. DWI contours were generated by manual segmentation. Tumor volume similarity was evaluated using the [PET]/[ADC] volume proportion, Dice’s coefficient, and the mean SUV iso-threshold at the surface of each ADC contour. Tumor sub-volume similarity was evaluated ANOVA. Results The [PET]/[ADC] volume proportion was 0.88 ± 0.14. Dice’s coefficient between PET and ADC tumor contours was 0.76 ± 0.06. The mean SUV isothreshold at the ADC-delineated tumor surface was 34 ± 4%. Sub-volumes with increased metabolic activity on FDG-PET also had more restricted diffusion on DWI (p < 0.0001, ANOVA). Conclusion Concordance of functional imaging is observed between FDG-PET and DWI for cervical cancer. Tumor sub-volumes with increased metabolic activity on FDG-PET also have greater cell density by DWI.

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“…Our interpretation of such results takes into consideration that SI on T2 sequences could be representative of tumor-stroma architecture, tumor permeability, or peri-tumoral inflammation. A relative low signal intensity could be interpreted as a sign of tissue hypercellularity and a more crammed, hypovascular organization ( 28 ). GLSZM's LAHGLE could be a manifestation of tumor heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Anal squamous cell carcinoma: Impact of radiochemotherapy evolution over years and an explorative analysis of MRI prediction of tumor response in a mono-institutional series of 131 patients

Bonù

Mattina²,

Singh³

et al. 2022

Front. Oncol.

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IntroductionRadiochemotherapy (RCHT) for the treatment of anal squamous cell carcinoma (ASCC) has evolved dramatically, also thanks to intensity-modulated RT (IMRT) and 3D image guidance (3D IGRT). Despite most patients presenting fair outcomes, unmet needs still exist. Predictors of poor tumor response are lacking; acute toxicity remains challenging; and local relapse remains the main pattern of failure.Patients and methodsBetween 2010 and 2020, ASCC stages I–III treated with 3D conformal radiotherapy or IMRT and CDDP-5FU or Mytomicine-5FU CHT were identified. Image guidance accepted included 2D IGRT or 3D IGRT. The study endpoints included freedom from locoregional recurrence (FFLR), colostomy free survival (CFS), freedom from distant metastasis (FFDM), overall survival (OS), and acute and late toxicity as measured by common terminology criteria for adverse events (CTCAE) version 5.0. An exploratory analysis was performed to identify possible radiomic predictors of tumor response. Feature extraction and data analysis were performed in Python™, while other statistics were performed using SPSS® v.26.0 software (IBM®).ResultsA total of 131 patients were identified. After a median FU of 52 months, 83 patients (63.4%) were alive. A total of 35 patients (26.7%) experienced locoregional failure, while 31 patients (23.7%) relapsed with distant metastasis. Five year FFLR, CFS, DMFS and PS resulted 72.3%, 80.1%, 74.5% and 64.6%. In multivariate analysis, 2D IGRT was associated with poorer FFLR, OS, and CFS (HR 4.5, 4.1, and 5.6, respectively); 3DcRT was associated with poorer OS and CFS (HR 3.1 and 6.6, respectively). IMRT reduced severe acute gastro-intestinal (GI) and severe skin acute toxicity in comparison with 3DcRT. In the exploratory analysis, the risk of relapse depended on a combination of three parameters: Total Energy, Gray Level Size Zone Matrix’s Large Area High Gray Level Emphasis (GLSZM’s LAHGLE), and GTV volume.ConclusionsAdvances in radiotherapy have independently improved the prognosis of ASCC patients over years while decreasing acute GI and skin toxicity. IMRT and daily 3D image guidance may be considered standard of care in the management of ASCC. A combination of three pre-treatment MRI parameters such as low signal intensity (SI), high GLSZM’s LAHGLE, and GTV volume could be integrated in risk stratification to identify candidates for RT dose-escalation to be enrolled in clinical trials.

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Change in T2-Fat Saturation MRI Correlates With Outcome in Cervical Cancer Patients

Cited by 8 publications

References 27 publications

Radiomics Analysis of Multiparametric MRI Evaluates the Pathological Features of Cervical Squamous Cell Carcinoma

Radiomics Analysis of Multiparametric MRI Evaluates the Pathological Features of Cervical Squamous Cell Carcinoma

Tumor volume and subvolume concordance between FDG‐PET/CT and diffusion‐weighted MRI for squamous cell carcinoma of the cervix

Anal squamous cell carcinoma: Impact of radiochemotherapy evolution over years and an explorative analysis of MRI prediction of tumor response in a mono-institutional series of 131 patients

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