Change in the microstructure of particles of perfluorocarbon emulsions on storage in the frozen state

Blood serum protein sorption on the surface of perfluorocarbon emulsion particles

“…For this, the interaction indices (K t , K t/n ) of the emulsions with the biological medium were found [9]. The relative turbidity K t and the adjusted relative turbidity K t/n were:…”

“…The particle surface properties are difficult to evaluate because of the indefinite composition and strength of the structural-mechanical barrier of surfactant molecules around the particles and the ill-defined spatial orientation of surfactant molecules in this layer. An indirect method for characterizing the surface properties of PFC particles that uses the interaction index of PFC emulsions with blood serum was proposed [9].…”

Physicochemical parameters of perfluorocarbon emulsions with different osmolarities

“…Changes in these indexes provide indirect reflections of changes in the "microstructure" of emulsions depending on the state of surfactant molecules in the layer around the particles, their mutual positions, their degrees of ordering, oxidation, etc. [11].…”

“…Mean particle size a in the initial state and values of a in the fractions (i.e., the particle size distribution) characterize the "overall structure" of PFC emulsions. Indexes of particle interaction with serum (K t , K t / n ) [10] were also determined for PFC emulsions: relative turbidity K t and adjusted relative turbidity K t / n…”

“…Results evidencing persistence of the structures of emulsions of different osmolarities in different storage conditions were verified by comparing experimental and calculated values for turbidity (t, Equation 6). Measurement of t provides an independent parameter for assessing the structural integrity of PFC emulsions [11]. We have previously demonstrated that when free PL appear in PFC/PL emulsions, the calculated and experimental values for turbidity do not coincide [18].…”