Change in the ovarian environment after hysterectomy with bilateral salpingectomy: is it the technique or surgery itself?

Atalay, Mehmet Aral; Demir, Bilge Çetinkaya; Özerkan, Kemal

doi:10.1016/j.ejogrb.2016.07.483

Cited by 12 publications

(32 citation statements)

References 22 publications

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“…Our results are consistent with the study of Atalay et al . that presented elevated levels of FSH and LH within 6 months after surgery[21] but is inconsistent with the study of Song et al . [14]…”

Section: Discussioncontrasting

confidence: 68%

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Evaluation of ovarian function after hysterectomy with or without salpingectomy: A feasible study

Behnamfar

Jabbari

2017

J Res Med Sci

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Background:Prophylactic salpingectomy for the prevention of ovarian cancer has been recommended strongly. The aim of this study was to compare ovarian function in patients who undergo hysterectomy for benign reasons with or without bilateral salpingectomy.Materials and Methods:This was a clinical-trial study on patients undergone hysterectomy with/without bilateral salpingectomy in Al-Zahra Hospital, in 2015–2016. Demographic information (age, height, and weight) were recorded. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured in 2–5 days of menstrual cycle before operation. Patients were asked to refer in 6 months for follow-up, including FSH and LH re-measurement and also menopausal status examination. Patients were divided into age groups of 39–45, 46–50, and ≥51 and also groups of body mass index including 18.5–24.9, 25–29.9, and 30–34.9.Results:A total of 37 patients divided into two groups, including 22 patients undergone hysterectomy without salpingectomy (H) and 15 undergone hysterectomy with bilateral salpingectomy (H-bS). The mean age (standard deviation) of Group H was 47.77 (3.03) and Group H-bS was 48.47 (2.03) (P > 0.05). Furthermore, the mean level of FSH and LH before surgery was not significantly different (P > 0.05). The mean level of FSH and LH changes was not significant between H and H-bS groups (P = 0.17), (P = 0.16).Conclusion:Bilateral salpingectomy during hysterectomy did not increase the risk of ovarian dysfunction after 6 months follow-up.

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Section: Discussioncontrasting

confidence: 68%

“…reported the same results among patients >40 years versus <40 years undergone total abdominal hysterectomy-bilateral salpingectomy or laparoscopic hysterectomy-bilateral salpingectomy. [21]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ovarian function after hysterectomy with or without salpingectomy: A feasible study

Behnamfar

Jabbari

2017

J Res Med Sci

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“…Analysis of three studies in group 1 ( n = 368) with participants >40 years also revealed no statistically significant change in serum AMH concentration (WMD −0.10 ng/mL; 95% CI −0.20 to 0.00; I 2 = 0%) .…”

Section: Resultsmentioning

confidence: 94%

“…In four studies, participants had normal fallopian tubes, which were removed during a gynecological procedure including hysterectomy , myomectomy or sterilization . In three other studies, participants underwent salpingectomy due to tubal ectopic pregnancy .…”

Section: Resultsmentioning

confidence: 99%

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Ovarian reserve after salpingectomy: a systematic review and meta‐analysis

Mohamed

Yosef

James³

et al. 2017

Acta Obstet Gynecol Scand

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Introduction. Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. Material and methods. A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-M€ ullerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into REVMAN software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154). Results. Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, À0.10 ng/mL; 95% CI À0.19 to 0.00, I 2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, À0.11 ng/ mL; 95% CI À0.37 to 0.14, I 2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants' age (<40 years) still showed no statistically significant changes in circulating AMH. Conclusion. Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain.

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