Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

Pierno, Sabata; Desaphy, Jean Francois; Liantonio, Antonella; Bellis, Michela De; Bianco, Gianpatrizio; A, De Luca; Frigeri, Antonio; Nicchia, Grazia Paola; Svelto, María; Léoty, Claude; George, Alfred L.; Camerino, Diana Conte

doi:10.1093/brain/awf162

Cited by 71 publications

(128 citation statements)

References 45 publications

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“…Studies carried out in rat and mouse muscles show that chloride conductance is higher in fast compared with slow muscle, and this is due to the higher level of expression of ClC1 in fast fibers, but also to the greater inactivation of ClC1 mediated by protein kinase C (PKC) phosphorylation in slow fibers (109,612). Several conditions that induce a fiber type transition are associated with the expected changes in ClC1 expression (611) and with changes in PKC-mediated inactivation (612). C) POTASSIUM CHANNELS.…”

Section: Ionic Channels and Membrane Excitabilitymentioning

confidence: 99%

Fiber Types in Mammalian Skeletal Muscles

Schiaffino

Reggiani

2011

Physiological Reviews

2,313

2,465

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Mammalian skeletal muscle comprises different fiber types, whose identity is first established during embryonic development by intrinsic myogenic control mechanisms and is later modulated by neural and hormonal factors. The relative proportion of the different fiber types varies strikingly between species, and in humans shows significant variability between individuals. Myosin heavy chain isoforms, whose complete inventory and expression pattern are now available, provide a useful marker for fiber types, both for the four major forms present in trunk and limb muscles and the minor forms present in head and neck muscles. However, muscle fiber diversity involves all functional muscle cell compartments, including membrane excitation, excitation-contraction coupling, contractile machinery, cytoskeleton scaffold, and energy supply systems. Variations within each compartment are limited by the need of matching fiber type properties between different compartments. Nerve activity is a major control mechanism of the fiber type profile, and multiple signaling pathways are implicated in activity-dependent changes of muscle fibers. The characterization of these pathways is raising increasing interest in clinical medicine, given the potentially beneficial effects of muscle fiber type switching in the prevention and treatment of metabolic diseases.

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Section: Ionic Channels and Membrane Excitabilitymentioning

confidence: 99%

Fiber Types in Mammalian Skeletal Muscles

Schiaffino

Reggiani

2011

Physiological Reviews

2,313

2,465

View full text Add to dashboard Cite

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“…In mammalian skeletal muscle, innervation upregulates and denervation downregulates I IR expression (205), effects that appear to be secondary to activity-induced increases in [Ca 2ϩ ] i that stabilize IRK1 mRNA (540). Chloride channels also contribute to resting conductance, particularly in skeletal muscle, and their development appears to be dependent on innervation-induced electrical activity (236,293,482).…”

Section: ؉ -Gated Channelsmentioning

confidence: 99%

Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells

Moody¹,

Bosma²

2005

Physiological Reviews

344

323

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At specific stages of development, nerve and muscle cells generate spontaneous electrical activity that is required for normal maturation of intrinsic excitability and synaptic connectivity. The patterns of this spontaneous activity are not simply immature versions of the mature activity, but rather are highly specialized to initiate and control many aspects of neuronal development. The configuration of voltage- and ligand-gated ion channels that are expressed early in development regulate the timing and waveform of this activity. They also regulate Ca2+ influx during spontaneous activity, which is the first step in triggering activity-dependent developmental programs. For these reasons, the properties of voltage- and ligand-gated ion channels expressed by developing neurons and muscle cells often differ markedly from those of adult cells. When viewed from this perspective, the reasons for complex patterns of ion channel emergence and regression during development become much clearer.

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“…Previous studies have shown that immobilisation and unloading can result in a transition from slow to fast myofibres (Roy et al, 1996;Pierno et al, 2002). The transition occurs when the myofibres shift towards a myosin isoform with higher ATPase activity (Diffee et al, 1991).…”

Section: B L Mantle and Othersmentioning

confidence: 99%

Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation inCyclorana alboguttata(Günther 1867)

Mantle

Hudson

Harper

et al. 2009

Journal of Experimental Biology

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SUMMARYWe investigated the effect of prolonged immobilisation of six and nine months duration on the morphology and antioxidant biochemistry of skeletal muscles in the amphibian aestivator Cyclorana alboguttata. We hypothesised that, in the event of atrophy occurring during aestivation, larger jumping muscles were more likely to be preserved over smaller non-jumping muscles. Whole muscle mass (g), muscle cross-sectional area (CSA) (mm 2 ), water content (%) and myofibre number (per mm 2 ) remained unchanged in the cruralis muscle after six to nine months of aestivation; however, myofibre area (mm 2 ) was significantly reduced. Whole muscle mass, water content, myofibre number and myofibre CSA remained unchanged in the gastrocnemius muscle after six to nine months of aestivation. However, iliofibularis dry muscle mass, whole muscle CSA and myofibre CSA was significantly reduced during aestivation. Similarly, sartorius dry muscle mass, water content and whole muscle CSA was significantly reduced during aestivation. Endogenous antioxidants were maintained at control levels throughout aestivation in all four muscles. The results suggest changes to muscle morphology during aestivation may occur when lipid reserves have been depleted and protein becomes the primary fuel substrate for preserving basal metabolic processes. Muscle atrophy as a result of this protein catabolism may be correlated with locomotor function, with smaller non-jumping muscles preferentially used as a protein source during fasting over larger jumping muscles. Higher levels of endogenous antioxidants in the jumping muscles may confer a protective advantage against oxidative damage during aestivation; however, it is not clear whether they play a role during aestivation or upon resumption of normal metabolic activity.

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Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse

Cited by 71 publications

References 45 publications

Fiber Types in Mammalian Skeletal Muscles

Fiber Types in Mammalian Skeletal Muscles

Ion Channel Development, Spontaneous Activity, and Activity-Dependent Development in Nerve and Muscle Cells

Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation inCyclorana alboguttata(Günther 1867)

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