Change of HeART: Cardiovascular Implications of Assisted Reproductive Technology

Niazi, Elaha; Dumanski, Sandra M.

doi:10.1016/j.cjco.2023.09.008

Cited by 1 publication

(1 citation statement)

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“…Hence, some response bias might be present. Females with history of ART were more frequently on hormone replacement therapy, which could have altered the results on vascular function [51]. We did not acquire data on an individual's menstrual cycle, which could potentially alter cardiovascular function.…”

Section: Study Design and Study Populationmentioning

confidence: 99%

Vascular Health of Females with History of Assisted Reproductive Technology

Li,

Langer,

Vilsmaier

et al. 2024

JCDD

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The use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the overall vascular health of females with history of ART compared to individuals who conceived spontaneously. The assessment of overall vascular health included the measurement of brachial blood pressure, central blood pressure, and pulse wave velocity, as well as the evaluation of the arterial stiffness and carotid intima-media thickness (cIMT) of the common carotid arteries. Conventional blood lipids including lipoprotein a (Lp(a)) were also determined. In total, 45 females with history of ART and 52 females who conceived spontaneously were included (mean age: 47.72 ± 5.96 years vs. 46.84 ± 7.43 years, p = 0.525). An initial comparison revealed a significantly higher prevalence of elevated Lp(a) in ART females (p = 0.011). However, after multiple comparison correction, the significant result disappeared (p = 0.132). Within the cohort of ART females, no significantly higher cardiovascular risk was detected regarding vascular function. The potentially higher prevalence of elevated Lp(a) in ART females must be further investigated in future studies, as it might contribute to the impaired reproductive process in this cohort.

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Section: Study Design and Study Populationmentioning

confidence: 99%