Change of Pulsatility Index of the Fetal Middle Cerebral Artery after Auditory Stimulation in No Risk Pregnancies and in Pregnancies with Gestational Hypertension

Plešinac, Snežana; Janković, Srdja; Plecas, Darko; Antonovic, Olga; Adamovic, Tatjana; Sovilj, Mirjana

doi:10.3109/10641963.2013.776571

Cited by 5 publications

(13 citation statements)

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“…Several research groups have already demonstrated the link between fetal evoked responses to auditory stimuli and conditions during labor (Eswaran et al, 1999;Luz, 1985;Luz, Lima, Luz, & Feldens, 1980). In a large group of subjects, increase in fetal MCA flow was associated with gestational hypertension when compared to normotension (Plesinac et al, 2013). The objective of the present study was to establish whether there is a potential correlation between antenatal maternal anxiety and changes in blood flow in the fetal MCA in normotensive and gestational hypertensive subjects and if maternal anxiety acts additively with gestational hypertension.…”

Section: Discussionmentioning

confidence: 86%

“…PAS was performed essentially following the protocol of Sovilj et al (1992) as previously described (Dobrijević et al, 2009; Jankovic-Raznatovic et al, 2014; Plesinac et al, 2013). Standard ultrasound examination was employed to determine that fetuses were in proper health and awakemoving limbs, yawning, blinking, etc.…”

Section: Prenatal Acoustic Screening (Pas) and Doppler Sonographymentioning

confidence: 99%

“…The PAS aims to detect developmental auditory system impairments (Dobrijević et al, 2009;Plesinac et al, 2013;Sovilj, Ljubic, Milenkovic, & ðokovic, 1992). The method comprises of sonographic measurements of fetal reactions to a defined sound stimuli expressed using several sonographic/Doppler parameters with regards to the fetal MCA.…”

mentioning

confidence: 99%

“…Changes have been described in reactive Pi index (PiR) compared to baseline Pi (PiB) when carrying out PAS procedures, representing a potential indicator of gross hearing and developmental impairment of the fetus (Dobrijević et al, 2009). It was demonstrated previously that high-risk pregnancy was associated with significantly altered relative pulsatility (RePi) values by more than ±12% when compared to healthy control (Dobrijević et al, 2009;Plesinac et al, 2013). The RePi is representative of the percentage of PiR value change after normalization by PiB values.…”

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confidence: 99%

“…The RePi is representative of the percentage of PiR value change after normalization by PiB values. Dobrijević et al (2009) demonstrated that PAS measurements of RePi might be useful as indicators of psychophysiological development during the early postnatal period (Dobrijević et al, 2009;Plesinac et al, 2013).…”

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confidence: 99%

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Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Vujović¹,

Sovilj²,

Jeličić³

et al. 2017

Developmental Psychobiology

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This study investigated the correlation between maternal anxiety and blood flow changes through the fetal middle cerebral artery (MCA) after defined acoustic stimulation in 43 normotensive (C) and 40 gestational hypertensive (GH) subjects.Neonatal outcomes (gestational age at birth, Apgar score, birth weight) in the C and GH groups were analyzed. State (STAI-S) and trait (STAI-T) anxiety was assessed using Spielberger's questionnaire. The MCA blood flow was assessed once between 28 and 41 weeks of gestation using color Doppler ultrasound before and after application of defined acoustic stimulus. Relative size of the Pulsatility index (Pi) change (RePi) was calculated. The general hypotheses were: (1) women in GH group would have higher anxiety; (2) higher anxiety correlates with higher RePi change and poorer neonatal outcome; (3) fetuses from the GH group would have poorer neonatal outcome.Subjects from the GH group had higher STAI-T and RePi compared to the C group. A positive correlation between RePi and STAI-S, STAI-T, and systolic/diastolic blood pressure was found in both groups. There were more preterm deliveries in the GH group compared to the C group. A significant effect of STAI-T on body weight was observed in the C and GH group. There was a predictive effect of STAI-T and RePi on the C group, and STAI-S, STAI-T, diastolic blood pressure, and RePi on the GH group in terms of neonatal body weight. This study demonstrates an association between antenatal anxiety in GH women and increased fetal cerebral circulation in response to defined auditory stimulation. K E Y W O R D Sbirth outcomes, defined acoustic stimulation, fetal cerebral circulation, gestational hypertension, maternal anxiety

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Section: Discussionmentioning

confidence: 86%

Section: Prenatal Acoustic Screening (Pas) and Doppler Sonographymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Vujović¹,

Sovilj²,

Jeličić³

et al. 2017

Developmental Psychobiology

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Fetus Sound Stimulation: Cilia Memristor Effect of Signal Transduction

Jankovic-Raznatovic

Dragojević-Dikić

Rakic

et al. 2014

BioMed Research International

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Background. This experimental study evaluates fetal middle cerebral artery (MCA) circulation after the defined prenatal acoustical stimulation (PAS) and the role of cilia in hearing and memory and could explain signal transduction and memory according to cilia optical-acoustical properties. Methods. PAS was performed twice on 119 no-risk term pregnancies. We analyzed fetal MCA circulation before, after first and second PAS. Results. Analysis of the Pulsatility index basic (PIB) and before PAS and Pulsatility index reactive after the first PAS (PIR 1) shows high statistical difference, representing high influence on the brain circulation. Analysis of PIB and Pulsatility index reactive after the second PAS (PIR 2) shows no statistical difference. Cilia as nanoscale structure possess magnetic flux linkage that depends on the amount of charge that has passed between two-terminal variable resistors of cilia. Microtubule resistance, as a function of the current through and voltage across the structure, leads to appearance of cilia memory with the “memristor” property. Conclusion. Acoustical and optical cilia properties play crucial role in hearing and memory processes. We suggest that fetuses are getting used to sound, developing a kind of memory patterns, considering acoustical and electromagnetically waves and involving cilia and microtubules and try to explain signal transduction.

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Effect of antenatal maternal anxiety on the reactivity of fetal cerebral circulation to auditory stimulation, and early child development

Vujović¹,

Sovilj²,

Plešinac³

et al. 2019

Srp Arh Celok Lek

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Introduction/Objective Antenatal maternal anxiety (AMA) can have negative impact on a child's preand postnatal development. The aim of the study was to examine the effect of AMA on changes in fetal blood flow through the middle cerebral artery (MCA) after acoustic stimulation, on birth outcome, and on early child development. Methods Forty-three women in the third trimester of pregnancy and their children were enrolled into a longitudinal prospective study. The AMA (state and trait) was assessed using Spielberger's questionnaire. The MCA blood flow was assessed using Doppler ultrasound before and after the defined acoustic stimulus. The data regarding neonatal body weight, Apgar score, first step and word appearance, estimated speech-language (ESLD), sensory-motor (ESMD), and social-emotional (ESED) development at the age of three were collected. Results Fetuses from mothers with high state and trait anxiety had slower reaction time and higher relative pulsatility index after defined auditory stimulation. There are more preterm deliveries, lower scores on ESLD, ESMD, and ESED in mothers with high State-Trait Anxiety Inventory personality trait (STAI-T) compared to low. There is a negative correlation between reaction time, relative pulsatility index, STAI-T and ESLD. Conclusions High levels of antenatal maternal trait anxiety could have a negative effect on both fetal reactivity to sound stimulation and early child development.

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Change of Pulsatility Index of the Fetal Middle Cerebral Artery after Auditory Stimulation in No Risk Pregnancies and in Pregnancies with Gestational Hypertension

Abstract: An average change of PI of median cerebral artery was higher in this group.

Cited by 5 publications

References 4 publications

Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Fetus Sound Stimulation: Cilia Memristor Effect of Signal Transduction

Effect of antenatal maternal anxiety on the reactivity of fetal cerebral circulation to auditory stimulation, and early child development

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