Change of Vertebral Left Atrial Size in Dogs With Preclinical Myxomatous Mitral Valve Disease Prior to the Onset of Congestive Heart Failure

Lee, Dohee; Yun, Taesik; Koo, Yoonhoi; Chae, Yeon; Ku, Dayoung; Chang, Dongwoo; Kang, Byeong‐Teck; Yang, Mhan‐Pyo; Kim, Hakhyun

doi:10.1016/j.jvc.2022.05.003

Cited by 3 publications

(8 citation statements)

References 27 publications

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“…However, one previous study proposed a mitral valve disease severity score using left atrial and ventricle dimension, systolic function, and E‐wave velocity grouping dogs into mild, moderate, severe, and end‐stage, and the survival time was correlated with the disease severity 3 . Moreover, several studies had shown that both VHS and VLAS can be used in long term monitoring of dogs with MMVD and even as outcome predictors 13,14,16 . This study has several limitations.…”

Section: Discussionmentioning

confidence: 91%

“…3 Moreover, several studies had shown that both VHS and VLAS can be used in long term monitoring of dogs with MMVD and even as outcome predictors. 13,14,16 This study has several limitations. Only one right lateral radiography was used for both VHS and VLAS measurements.…”

Section: Discussionmentioning

confidence: 96%

“…Only one right lateral radiography was used for both VHS and VLAS measurements. However, most of the previous studies have used the same recumbence for analysis in both healthy and diseased dogs 8,13,23,24,27 . Moreover, some studies reported no significant differences between left and right recumbence 7,28 .…”

Section: Discussionmentioning

confidence: 99%

“…However, most of the previous studies have used the same recumbence for analysis in both healthy and diseased dogs. 8,13,23,24,27 Moreover, some studies reported no significant differences between left and right recumbence. 7,28 Second, our population was overrepresented by Maltese dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, one study proposed echocardiographic thresholds for different categories of left atrial dimension in dogs, resulting in four classes: normal, mild, moderate, and severe enlargement 5 however, echocardiography may not be always available and many studies assessed the diagnostic accuracy of cardiac size and left atrial size radiographic measurements in both healthy dogs and dogs with cardiac enlargement 6–12 . Moreover, radiographic measurements of the heart may be used for the assessment of the disease progression 13–16 . To date, the radiographic heart and LA size measurements have not yet been explored based on this new classification.…”

Section: Introductionmentioning

confidence: 99%

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Determination of radiographic vertebral heart score and vertebral left atrial size cutoffs based on echocardiographic left atrial size in dogs with myxomatous mitral valve disease

Baisan,

Vulpe

2023

Vet Radiology Ultrasound

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Progression of myxomatous mitral valve disease (MMVD) in dogs is a common cause of left atrial enlargement. Recently, a classification of left atrial (LA) size based on echocardiographic measurement has been proposed. This study aims to determine the radiographic LA size by reporting the cutoff values of VHS and VLAS for different groups of echocardiographic‐measured LA size in dogs with MMVD. This retrospective analytical cross‐sectional study included dogs diagnosed with MMVD grouped based on the echocardiographic LA size into normal (LA/Ao < 1.6), mild (1.6–1.89), moderate (1.9–2.2), and severe enlargement (>2.2) and were compared with ACVIM classification. VHS and VLAS were measured on the right lateral radiograph for each dog and cutoff values were calculated. One hundred and three dogs with MMVD were included in the study. A very strong positive correlation was observed between LA/Ao ratio and VHS (rs, 0.823, P < .01) or VLAS (rs, 0.834, P < .01). For VHS, a cutoff of 10.7 v, 11 v, and 11.5 v were established for echocardiographic LA thresholds of 1.6, 1.9, and 2.2 with a sensitivity of 79%, 92%, and 90% and a specificity of 97%, 90.7%, and 78.1%, respectively. For VLAS, a cutoff of 2.5 v, 2.7 v, and 2.9 v were established for echocardiographic LA cutoffs of 1.6, 1.9, and 2.2 with a sensitivity of 73%, 80%, and 83.3% and a specificity of 94%, 92%, and 86.3%, respectively. The results of this study may facilitate clinical decisions based on radiographic examination in dogs with myxomatous mitral valve disease.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Determination of radiographic vertebral heart score and vertebral left atrial size cutoffs based on echocardiographic left atrial size in dogs with myxomatous mitral valve disease

Baisan,

Vulpe

2023

Vet Radiology Ultrasound

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Application of A Dual-Stage Deep Learning Framework to Detect Left Atrial Enlargement for Pet Heart Failure

Oh,

Lee,

Chang

et al. 2023

2023 IEEE International Conference on Systems, Man, and Cybernetics (SMC)

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Radiographic Left Atrial Size Measurement of Dogs in Different Mitral Valve Disease Stages with Four Different Methods

Marbella Fernández,

Montoya-Alonso

2023

Animals

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The left atrial size increases (LAS) in patients with mitral valve disease (MVD) as the disease progresses. The vertebral left atrial size (VLAS), the modified-vertebral left atrial size (M-VLAS), and the radiographic left atrial dimension (RLAD) are methods reported to assess LAS on dogs’ radiographs. All these methods transform the LAS into vertebral units. The thoracic inlet (TI) has been used as a reliable reference point to measure the cardiac silhouette of dogs with MVD in different stages. The objective of this study was to assess the clinical utility of measuring a dog LAS on right thoracic X-rays using the TI as a reference and determine whether it could differentiate dogs in different MVD stages. LAS was divided by the TI to obtain the thoracic inlet left atrial score (TILAS). This was a retrospective observational study including 135 apparently healthy dogs performed to assess their LAS with four different methods: VLAS, M-VLAS, RLAD, and TILAS. Thirty-six dogs from the general population were selected and compared to 100 dogs in different MVD stages. The TILAS was significantly different between the control dogs and MVD dogs, increasing with the disease stage: control dogs 0.51 ± 0.08, B1 0.57 ± 0.14, B2 0.75 ± 0.13, and C 0.84 ± 0.18. VLAS, M-VLAS, and RLAD also increased as the disease progressed, as shown in previous studies. The TILAS accuracy to distinguish MVD dogs with cardiac enlargement was comparable to VLAS, M-VLAS, and RLAD (AUC 0.91 vs. 0.93, 0.90, and 0.94 respectively). A TILAS > 0.8 can identify dogs with cardiac enlargement secondary to MVD.

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Change of Vertebral Left Atrial Size in Dogs With Preclinical Myxomatous Mitral Valve Disease Prior to the Onset of Congestive Heart Failure

Cited by 3 publications

References 27 publications

Determination of radiographic vertebral heart score and vertebral left atrial size cutoffs based on echocardiographic left atrial size in dogs with myxomatous mitral valve disease

Determination of radiographic vertebral heart score and vertebral left atrial size cutoffs based on echocardiographic left atrial size in dogs with myxomatous mitral valve disease

Application of A Dual-Stage Deep Learning Framework to Detect Left Atrial Enlargement for Pet Heart Failure

Radiographic Left Atrial Size Measurement of Dogs in Different Mitral Valve Disease Stages with Four Different Methods

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