Changed serum levels of CD62E+, angiotensin II and copeptin in patients with chronic insomnia disorder: a link between insomnia and stroke?

Chen, Juntao; Zhang, Ping; Kong, Xiao-Yi; Ge, Yuxiang; Li, Xueyan; Yang, Shuai; He, Shuo; Chen, Guihai

doi:10.1016/j.sleep.2022.02.017

Cited by 7 publications

(7 citation statements)

References 57 publications

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“…This leads to angiotensin increased secretion and release of angiotensin II (Ang II). [39][40][41][42][43][44][45] Ang II is the main effector of the RAAS. It can cause contraction of arteriole smooth muscle and stimulate the adrenal cortex globular zone to secrete aldosterone, which increases the secretion of norepinephrine through the positive feedback of the presynaptic membrane of the sympathetic nerve endings, resulting in an increase in blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital

Shi¹,

Ding²,

Hu³

et al. 2023

IDR

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Objective To evaluate the effect of sleep duration on blood pressure in patients with hypertension urgencies combined with SARS-CoV-2 infection in a Fangcang shelter hospital. Methods From April 10, 2020 to May 20, 2022, we statistically analyzed the blood pressure and sleep conditions of 52 patients with combined hypertension urgencies and SARS-CoV-2 infection admitted in Shanghai National Convention and Exhibition Center Fangcang shelter hospital. They were divided into the short-term (daily sleep duration: <7 h) and normal sleep group (7–9 h). We performed a comparison of the control effects of basic antihypertensive drugs. Additionally, patients in the short-term sleep group underwent drug therapy for sleep regulation and continuous monitoring of blood pressure. Results Among these patients, the blood pressure was higher in the short-term sleep group than that of the normal sleep group, and also more difficult to control ( p <0.05). Furthermore, the blood pressure of the patients in the short-term sleep group was more easily controlled after treatment with drugs for sleep regulation and basic antihypertensive drugs ( p <0.05). Conclusion The blood pressure level in patients with combined SARS-CoV-2 infection and hypertension urgencies was higher in those with a shorter duration of daily sleep, and also more difficult to control in Fangcang shelter hospital. Drug therapy for sleep regulation should be administered early to obtain sufficient blood pressure control effects.

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Section: Discussionmentioning

confidence: 99%

Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital

Shi¹,

Ding²,

Hu³

et al. 2023

IDR

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“…ELISA was used to detect the levels of 5-HT, DA and GABA in the serum of each group of rats ( 29 ). The standard curve was operated and drawn according to the method in the kit instructions.…”

Section: Methodsmentioning

confidence: 99%

Valerian essential oil for treating insomnia via the serotonergic synapse pathway

Wang

Guo

et al. 2022

Front. Nutr.

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Valerian volatile oil can be used in the treatment of insomnia; however, the active components and mechanisms of action are currently unclear. Therefore, we used transcriptome sequencing and weight coefficient network pharmacology to predict the effective components and mechanism of action of valerian volatile oil in an insomnia model induced by intraperitoneal injection of para-Chlorophenylalanine (PCPA) in SD rats. Valerian essential oil was given orally for treatment and the contents of 5-hydroxytryptamine receptor 1 A (5-HT1AR), γ-aminobutyric acid (GABA), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA) in the hippocampus of rats in each group were detected by enzyme-linked immunosorbent assay (ELISA), western blot, Polymerase Chain Reaction (PCR), and immunohistochemistry. The results showed that after treatment with valerian essential oil, insomnia rats showed significantly prolonged sleep duration and alleviated insomnia-induced tension and anxiety. Regarding the mechanism of action, we believe that caryophyllene in valerian essential oil upregulates the 5-HT1AR receptor to improve the activity or affinity of the central transmitter 5-HT, increase the release of 5-HT, couple 5-HT with a G protein coupled receptor, convert adenosine triphosphate (ATP) into cAMP (catalyzed by ADCY5), and then directly regulate the downstream pathway. Following pathway activation, we propose that the core gene protein kinase PKA activates the serotonergic synapse signal pathway to increase the expression of 5-HT and GABA, thus improving insomnia symptoms and alleviating anxiety. This study provides a theoretical basis for the application of valerian volatile oil in health food.

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“…Several studies suggest a potential association between insomnia and an elevated risk of stroke 16 . Chronic insomnia problems may correlate with risk factors for cardiovascular diseases, including hypertension, diabetes, and atherosclerosis, which are also prominent risk factors for stroke 17 . Additionally, insomnia can cause decreased cerebral blood flow, leading to inadequate oxygen delivery to the brain and an elevated risk of stroke.…”

Section: Introductionmentioning

confidence: 99%

“…16 Chronic insomnia problems may correlate with risk factors for cardiovascular diseases, including hypertension, diabetes, and atherosclerosis, which are also prominent risk factors for stroke. 17 This study aims to ascertain the prevalence and potential risk factors of elder abuse in stroke survivors, while also examining its correlation with insomnia through face-to-face interviews. By identifying groups at high risk of elder abuse, the study intends to provide valuable information for screening, intervention, and prevention efforts related to elder abuse in stroke patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of elder abuse in survivors of stroke: A cross‐sectional study

Zhang,

Chen,

Xiao

et al. 2023

Health Science Reports

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Background and AimsThe understanding of the prevalence and risk factors associated with elder abuse in stroke survivors is currently lacking. Therefore, the objective of this study is to ascertain the prevalence and potential risk factors of elder abuse in stroke survivors, while also examining its correlation with insomnia.MethodsIn this cross‐sectional study, a total of 485 stroke survivors aged 65 years and older, who received treatment at the Emergency department of Shunde Hospital, Southern Medical University, were subjected to face‐to‐face interviews using the questionnaire on elder abuse from the Third Survey on Chinese Women's Social Status. A logistic regression analysis was employed to examine the association between risk factors and elder abuse among stroke survivors.Results62.27% of the participants reported experiencing elder abuse, with 14.85% of them indicating suffering from more than two subtypes of abuse. Factors such as residing in nursing homes, lower income, and smoking were found to increase the likelihood of experiencing elder abuse and all four subtypes of abuse. Additionally, advancing age was associated with a higher risk of experiencing all four subtypes of abuse, although it did not affect the occurrence of overall abuse. It is worth noting that the self‐reported prevalence of the four types of abuse by the elderly themselves was higher compared to the reports provided by caregivers.ConclusionElder abuse is prevalent among stroke survivors, especially those who are residing in nursing homes, with lower income, and smokers. Elder abuse significantly increased the prevalence of insomnia in stroke survivors. Further research is needed to better explore effective measures to reduce the prevalence of elder abuse of stroke survivors.

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Changed serum levels of CD62E+, angiotensin II and copeptin in patients with chronic insomnia disorder: a link between insomnia and stroke?

Cited by 7 publications

References 57 publications

Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital

Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital

Valerian essential oil for treating insomnia via the serotonergic synapse pathway

Prevalence and risk factors of elder abuse in survivors of stroke: A cross‐sectional study

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