Changes chemopreventive markers in colorectal cancer development after inulin supplementation

Hijová, Emília; Szabadosova,; Strojný, Ladislav; Bomba, Alojz

doi:10.4149/bll_2014_016

Cited by 12 publications

(11 citation statements)

References 15 publications

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“…Azoreductase reduces azo compound to mutagen (Rafii et al 1990). Effect of inulin supplementation on b-glucuronidase content has been reported (Rowland et al 1998;Hijova et al 2014). Current study indicated that administration of both hydrolysed inulins had the same effect on the reduction of the activities of colon cancer-associated enzymes including azoreductase, nitroreductase and b-glucuronidase (Table 2), when compared with the control group, due to the alteration of the colonic microbial load and its activities.…”

Section: Discussionmentioning

confidence: 79%

Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague–Dawley rats

Pattananandecha

Sirilun

Duangjitcharoen

et al. 2016

Pharmaceutical Biology

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Context Inulin, a non-digestible carbohydrate isolated from Helianthus tuberosus L. (Asteraceae), has been shown to alter the gut beneficial bacteria including Lactobacillus spp. and Bifidobacteria. Inulin also influences the activities of intestinal microbiota that could prevent the colon cancer development. Objective This study determines the effect of hydrolysed inulin with different degrees of polymerisation on alteration of intestinal microbiota and their activities on azoxymethane (AOM)-induced preneoplastic aberrant crypt foci (ACF) in rats. Materials and methods Seventy-two male Sprague-Dawley rats were randomly divided into six groups (three control and three AOM-treated groups) and the animal were fed with either a normal diet or diet containing 10% of long-chain inulin (InuL) or short-chain inulin (InuS), respectively, for 17 weeks. Colon cancer was induced in rats by injecting AOM subcutaneously at the 8th and 9th week of the study period. At the end of the experiment, cecal contents of rats were examined for selected microbiota, organic acids, putrefactive compounds and microbial enzymes. ACF formation was microscopically examined. Results The inulin diets significantly increased the weight and decreased the pH of the caecal content. The rats fed with InuL-supplemented diet showed approximately 2.9-and 6.8-fold increases in the biomass of Lactobacillus spp. and Bifidobacteria, respectively. Naive and AOMtreated rats fed with inulin-supplemented diet showed $1.3-and $2.2-fold decreases in the biomass of Escherichia coli and Salmonella enterica serovar Typhi, respectively. Inulins significantly decreased the colonic concentration of phenol, p-cresol and indole. Reduction in the activity of microbial enzymes such as b-glucuronidase, azoreductase and nitroreductase were observed in inulin-treated animals. Reduction in the ACF formation has been observed in inulin-treated groups. Discussion and conclusion The present study demonstrates that dietary administration of inulin reduces the formation of preneoplastic lesions in the colon, possibly by altering the microecology and microbial activities on carcinogenesis.ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 79%

Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague–Dawley rats

Pattananandecha

Sirilun

Duangjitcharoen

et al. 2016

Pharmaceutical Biology

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“…NOS2 gene expression and NO production are regulated by the transcription factors NFκB, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, and c-Jun NH2-terminal kinase (JNK)-activator protein-1 (AP-1) pathways (28), whereas they are downregulated by steroids, transforming growth factor (TGF)-β, the heat shock response element, and p53 (29). A previous report showed that Short-Chain Fatty Acids (SCFAs) decreased immunoreactivity and the number of COX-2, NFκB and iNOS positive cells in colon tissue (30). Moreover, another report demonstrated that SCFAs suppressed NFκB and the production of inflammatory cytokines such as IL-6 and TNF-α, but increased IL-10 secretion from macrophages (31).…”

Section: Discussionmentioning

confidence: 99%

Alteration of stomach microbiota compositions in the progression of gastritis induces nitric oxide in gastric cell

Dong

Feng

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Atrophic gastritis is considered to be an antecedent to intestinal metaplasia and gastric cancer. A previous study identified that Helicobacter pylori was absent at the severe atrophic gastritis stage, and alterations in the gastric microbial composition resembled those in gastric cancer. To explore the role of the bacteria absence of H. pylori in gastric carcinogenesis, in the current study, we compared the microbiota of clinically collected H. pylori-free gastric fluids from 30 patients with non-atrophic gastritis (N) and 22 patients with severe atrophic gastritis (S). We estimated the bacterial loads in the N and S groups by colony counting in culture agar as well as by measuring the concentration of the extracted DNA. The results showed a significant increase in bacterial load in patients with atrophic gastritis in comparison to non-atrophic gastritis. Then, we analyzed the microbial communities of the gastric fluids from all 52 patients using high-throughput sequencing of 16S rRNA amplicons. The Chao 1, Shannon and Simpson diversity indexes demonstrated that the bacterial richness and diversity were not significantly different between the N and S groups. Moreover, principal component analysis illustrated that the microbiomes from the S group were more scattered. Microbiota composition analysis showed that the entire dataset was clustered into 27 phyla, 61 classes, 106 orders, 177 families, 292 genera and 121 species. At the genus level, only the abundance of Prevotella was significantly different between the N and S groups. Further analysis showed that all the higher taxonomic categories were significantly different between the N and S groups. To assess the effects of the metabolic products of Prevotella spp. on gastric cell physiology, we treated the human gastric epithelial cell line AGS with acetic acid and monitored nitric oxide (NO) production. The results showed that acetic acid at low concentrations (0.5 and 5 µM) significantly inhibited AGS cells to secrete NO compared to phosphate buffer saline-treated control cells. These results suggest that the microbiota in non-atrophic gastritis may influence gastric epithelial cell physiology.

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“…157 Yapılan çalışmalarda da probiyotik ve prebi-yotiklerin kolorektal kanser üzerindeki potansiyel antikarsinojenik etkileri kanıtlanmıştır. [159][160][161][162][163] Probiyotik ve prebiyotiklerin kompozisyonu halinde kullanılan simbiyotiklerin de kolorektal kanser üzerine olumlu etkileri vardır. Yapılan bir çalışmada 12 hafta boyunca kolorektal kanserli ve polipektomili bireylere simbiyotik desteği (Lactobacillus rhamnosus GG, Bifidobacterium lactis Bb12, oligofruktoz ile zenginleştirilmiş inülin) verildiğinde bağırsak mikrobiyotasında laktobasil ve bifidobakteri sayısının arttığı ve C. perfringes miktarının azaldığı bulunmuştur.…”

Section: Beslenmeni̇n Kolorektal Kanser Oluşumunda Rolüunclassified

Different Mechanisms and the Role of Nutrition in the Formation of Colorectal Cancer

Atabilen¹,

Akbulut²

2019

Turkiye Klinikleri J Med Sci

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anser, ekonomik açıdan gelişmişlik derecesine bakılmaksızın toplumlar üzerinde büyük bir yük oluşturmaktadır. Özellikle günümüzde toplumların yaşlanma sorunuyla karşı karşıya kalmaları ve obezite, fiziksel inaktivite gibi risk faktörleri prevalansındaki artış kanser oluşum hızını artırmaktadır. Global kanser istatistikleri (GLOBOCAN) 2012 yılında dünyada 14,1 milyon yeni kanser vakası ve 8,2 milyon kansere bağlı mortalite oluştuğunu bildirmiştir. 1 Kanserler arasında sıralama yapıldığında

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Changes chemopreventive markers in colorectal cancer development after inulin supplementation

Cited by 12 publications

References 15 publications

Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague–Dawley rats

Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague–Dawley rats

Alteration of stomach microbiota compositions in the progression of gastritis induces nitric oxide in gastric cell

Different Mechanisms and the Role of Nutrition in the Formation of Colorectal Cancer

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