Changes During 24 Hours in the Lung Function and Histamine Hyperreactivity of the Bronchial Tree in Asthmatic and Bronchitic Patients

Vries, K. de; Goei, J.T.; Booy-Noord, H.; Orie, N.G.M.

doi:10.1159/000229248

Cited by 247 publications

(82 citation statements)

References 4 publications

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“…HDM sensitized asthmatic children residing for prolonged periods at high altitude, show clear improvements in airway hyperresponsiveness [7,8]. Sensitized asthmatic patients challenged in hospital with an allergen-containing aerosol usually develop a bronchial obstructive reaction [9,10]. When lung function has returned to baseline levels, airway hyperresponsiveness often remains increased for some time, during which patients demonstrate heightened responses to nonspecific stimuli, such as cold air, smoke etc.…”

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confidence: 99%

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Allergen reduction measures in houses of allergic asthmatic patients: effects of air-cleaners and allergen-impermeable mattress covers

Heide¹,

Kauffman²,

Dubois³

et al. 1997

Eur Respir J

100

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Recommendations for allergen avoidance or allergen reduction measures play an important part in the treatment of allergic asthmatic patients. The purpose of this study was to test recently developed air-cleaners with respect to their capacity to capture airborne allergen particles and to improve clinical parameters of asthmatic patients sensitized to aeroallergens.Forty five allergic asthmatic patients were studied in a double-blind procedure for 6 months. The patients were divided into three groups of 15 patients. In Group 1, the intervention consisted of the application of active air-cleaners in living-rooms and bedrooms. In Group 2, placebo air-cleaners were used in combination with allergen-impermeable mattress covers. In Group 3, the same intervention was performed as in Group 2 but with active air-cleaners. Allergen levels in mattress and floor dust were measured before, and 3 and 6 months after the interventions. After 6 months, the air-cleaners were dismantled and the filters were analysed for the amount of dust collected and allergen content. Immunological and lung function parameters were measured before, and 3 and 6 months after the interventions.Considerable amounts of airborne dust and allergenic particles were captured in the filters of the air-cleaners. Up to the 18.9 g of dust, 4,513 ng of house dust mite allergen, Der p 1, and 50,000 mU of cat allergen, Fel d 1, (in houses with cats) were collected by air-cleaners in living-rooms. Only in Group 3 (in which both active air-cleaners and mattress covers were used) was a small (less than 1 doubling dose) but statistically significant improvement of provocative concentration of histamine causing a 20% fall in forced expiratory volume in one second (PC20) observed (from 5.96 to 9.02 mg·mL -1 ). The amount of dust and house dust mite allergen collected in the filters was significantly correlated with an improvement of peak flow variation.In combination with other allergen avoidance measures, the examined air-cleaners can contribute to diminished allergen exposure and improvement of airway hyperresponsiveness in asthmatic patients.

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confidence: 99%

“…When lung function has returned to baseline levels, airway hyperresponsiveness often remains increased for some time, during which patients demonstrate heightened responses to nonspecific stimuli, such as cold air, smoke etc. [9,11]. Recommendations for allergen avoidance measures, therefore, play an important part in the treatment of allergic patients [1,12].…”

mentioning

confidence: 99%

Allergen reduction measures in houses of allergic asthmatic patients: effects of air-cleaners and allergen-impermeable mattress covers

Heide¹,

Kauffman²,

Dubois³

et al. 1997

Eur Respir J

100

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“…It has been demonstrated that bronchial hyperresponsiveness increases during the night (de Vries et al, 1962), but that an increased bronchial hyperresponsiveness during the night is not in itself responsible for nocturnal asthma (van Aalderen et al,, 1989), During allergic inflammatory processes mediators are released leading to an imbalance of the autonomic nervous system and a disruption of the airway epithelium (Hogg, 1981). Both factors increase probably bronchial hyperresponsiveness and diurnal variation in PEFR.…”

Section: Discussionmentioning

confidence: 99%

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

Reinberg¹,

Smolensky²,

Labrecque³

1990

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“…At that time, all were aged ,45 yrs and had AHR to histamine (30-s method; provocative concentration causing a 20% fall in FEV1 (PC20) f32 mg?mL -1 ) [28]. Between 1991 and 1999, the patients were extensively reexamined, as well as 200 spouses of these asthmatic probands [7,29].…”

Section: Study Populationsmentioning

confidence: 99%

SERPINE1-675 4G/5G polymorphism is associated with asthma severity and inhaled corticosteroid response

Dijkstra¹,

Postma

Bruinenberg³

et al. 2011

Eur Respir J

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Asthma is characterised by chronic airway inflammation and remodelling, which can be (partially) suppressed by inhaled corticosteroids (ICSs). Plasminogen activator inhibitor-1, encoded by the SERPINE1 gene, is the key inhibitor of the plasminogen activator system, which affects tissue repair and remodelling.We studied associations between a functional SERPINE1 -675 4G/5G promoter polymorphism and asthma development, severity and response to ICSs.Longitudinal cohorts of 281 asthmatics and their nonasthmatic spouses, and the general population (n51,390) were studied. No significant associations were found with asthma development and immunoglobulin (Ig)E levels, or with forced expiratory volume in 1 s (FEV1) in nonasthmatic controls. Asthmatic subjects carrying the SERPINE1 5G allele had higher IgE and lower lung function levels at follow-up, lower maximally attained lung function levels, and faster lung function decline compared with individuals with the 4G/4G genotype. ICS treatment showed an immediate improvement in FEV1 in asthmatics carrying the 5G allele. However, these asthmatics still had the fastest rate of FEV1 decline after initiating ICS treatment. Finally, the 5G allele was associated with a lower prevalence of complete asthma remission at follow-up.These findings suggest that SERPINE1 is not an asthma susceptibility gene, but rather affects the severity, progression and long-term ICS response in asthma.

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Changes During 24 Hours in the Lung Function and Histamine Hyperreactivity of the Bronchial Tree in Asthmatic and Bronchitic Patients

Cited by 247 publications

References 4 publications

Allergen reduction measures in houses of allergic asthmatic patients: effects of air-cleaners and allergen-impermeable mattress covers

Allergen reduction measures in houses of allergic asthmatic patients: effects of air-cleaners and allergen-impermeable mattress covers

Annual Review of Chronopharmacology. Volume 7. Biological Rhythms and Medications. Proceedings of the Conference of Chronopharmacology Held in Nice, France on 12-15 March 1990

SERPINE1-675 4G/5G polymorphism is associated with asthma severity and inhaled corticosteroid response

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