Changes in acetylcholinesterase, Na+,K+-ATPase, and Mg2+-ATPase activities in the frontal cortex and the hippocampus of hyper- and hypothyroid adult rats

Effect of adult onset hypothyroidism on behavioral parameters and acetylcholinesterase isoforms activity in specific brain regions of male mice

“…Our findings are in fully agreement with the available literature, indicating reduced total AChE activity in adult hypothyroid brain [8,65,66]. Furthermore, our results highlighted that TH deficiency did not affect the brain region-specific pattern distribution of AChE SS fraction activity; that is, cerebral cortex, cerebellum and hippocampus exhibited similar AChE SS fraction activity in euthyroid mice, a pattern which is preserved in the hypothyroid animals.…”

“…In addition, midbrain and striatum demonstrated double AChE SS activity compared with that of cerebral cortex, cerebellum and hippocampus in euthyroid mice and this pattern remained similar in the hypothyroid animals. The highest statistically significant impairment was observed in the cerebral cortex (32%), a brain region that has been related with several effects of hypothyroidism on adult brain [8,65]. Interestingly, it has been established that G1 isoform accumulation (SS fraction) protects neurons from damage associated with prolonged conflict behavior [67].…”

Neuroprotective effect of Alpinia galanga (L.) fractions on Aβ(25–35) induced amnesia in mice

“…Especially Na + /K + -ATPase in the brain promotes the generation of membrane potential and it consumes about 40-50% of ATP generated (Erecinska and Silver, 1994). The storage, uptake and metabolism of catecholamines are being implicated in energy metabolism in CNS by Na + /K + -ATPase (Carageorgiou et al, 2007). Previous studies suggested that Na + /K + -ATPase activities are reduced in frontal lobes of AD brain (Mark et al, 1995) and sporadic dementia of Alzheimer's type exerts lipid peroxidation of proteins and membrane lipids which in turns disrupts the membrane fluidity to inhibit Na + /K + -ATPase pump, also associated with elevated level of AChE and decreased the performance of hippocampal memory retention (Tauheed et al, 2009).…”

Postnatal Nitric Oxide Inhibition Modifies Neurotensin Effect on ATPase Activity

“…a P \ 0.05; aa P \ 0.01; aaa P \ 0.001 between time periods, by repeated measures ANOVA followed by Bonferroni comparison test. ns non-significant difference observed after administration of enzyme inhibitor ouabain [28] or in pathophysiological conditions such as hyper-or hypothyroidism [29]. Previous studies carried out in synaptosomal membranes isolated from cerebral cortex of Wistar adult rats showed that neurotensin inhibits Na ?…”