Changes in Alveolar Bone Height and Width Following Post‐Extraction Ridge Augmentation Using a Fixed Bioabsorbable Membrane and Demineralized Freeze‐Dried Bone Osteoinductive Graft

Zubillaga, G.; Hagen, Stanley Von; Simon, B; Deasy, Michael J.

doi:10.1902/jop.2003.74.7.965

Cited by 108 publications

(75 citation statements)

References 40 publications

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“…Interestingly, Fugazzotto 33 in a report on a comparison of resorbable and titanium-reinforced membranes used with Bio-Oss found that ''significant bucco-lingual ridge collapse was noted upon re-entry''. The findings of this paper are supported by the work of Zubillaga et al 34 who showed that tacked membranes in place results in less loss of augmented bone than non-tacked membranes.…”

Section: Bone Grafts and Membranes Togethersupporting

confidence: 85%

Ridge preservation: what is it and when should it be considered

Darby

Chen

Poi

2008

Australian Dental Journal

109

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The resorption of bone following extraction may present a significant problem in implant and restorative dentistry. Ridge preservation is a technique whereby the amount of bone loss is limited. This paper discusses the scientific literature examining the healing post‐extraction and ridge preserving techniques, primarily from the perspective of implant dentistry. Some indications for ridge preservation and methods considered appropriate are discussed.

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Section: Bone Grafts and Membranes Togethersupporting

confidence: 85%

Ridge preservation: what is it and when should it be considered

Darby

Chen

Poi

2008

Australian Dental Journal

109

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“…Several studies have reported significant structural changes and bone reabsorption in fresh sockets following tooth extraction, with important dimensional changes in the surrounding alveolar bone (1)(2)(3). A reduction of alveolar bone may present problems after tooth extraction, especially in aged individuals in whom bone volume is important for both physiological and medical reasons.…”

mentioning

confidence: 99%

Proteomic Analysis of Gingival Tissue and Alveolar Bone during Alveolar Bone Healing

Yang

Kwon

Kook

et al. 2013

Molecular & Cellular Proteomics

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Bone tissue regeneration is orchestrated by the surrounding supporting tissues and involves the build-up of osteogenic cells, which orchestrate remodeling/healing through the expression of numerous mediators and signaling molecules. Periodontal regeneration models have proven useful for studying the interaction and communication between alveolar bone and supporting soft tissue. We applied a quantitative proteomic approach to analyze and compare proteins with altered expression in gingival soft tissue and alveolar bone following tooth extraction. For target identification and validation, hard and soft tissue were extracted from mini-pigs at the indicated times after tooth extraction. From triplicate experiments, 56 proteins in soft tissue and 27 proteins in alveolar bone were found to be differentially expressed before and after tooth extraction. The expression of 21 of those proteins was altered in both soft tissue and bone. Comparison of the activated networks in soft tissue and alveolar bone highlighted their distinct responsibilities in bone and tissue healing. Moreover, we found that there is crosstalk between identified proteins in soft tissue and alveolar bone with respect to cellular assembly, organization, and communication. Among these proteins, we examined in detail the expression patterns and associated networks of ATP5B and fibronectin 1. ATP5B is involved in nucleic acid metabolism, small molecule biochemistry, and neurological disease, and fibronectin 1 is involved in cellular assembly, organization, and maintenance. Collectively, our findings indicate that bone regeneration is accompanied by a profound interaction among networks regulating cellular resources, and they provide novel insight into the molecular mechanisms involved in the healing of periodontal tissue after tooth extraction. Molecular & Cellular Proteomics

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“…41,42 Sinus lift surgery has been used by the dental profession to increase bone volume in the posterior maxilla and currently, the treatment of choice for posterior dental implant anchorage. [43][44][45][46][47] Density of host bone is crucial for implant [50][51][52][53][54] Guided dental surgery is a concept whereby the planning and installation of an implant is controlled to achieve precise results. [55][56][57][58][59][60][61] A number of guided surgery possibilities exist utilizing either analogue or digital technologies.…”

Section: Introductionmentioning

confidence: 99%

Synergy between 3D Models and Tissue Engineering to Optimize Sinus Lift, Implant Placement and Immediate Loading in Partially Edentulous Patients

Mahesh¹,

Restrepo²,

Restrepo³

2013

International Journal of Oral Implantology &Amp; Clinical Research

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Tissue engineering is a clinical approach toward the development of dynamic molecular delivery that can restore and improve regeneration. The 3D models and regenerative principles applied during implant guided dental surgery open new approaches for tissue constructs favoring sinus lift and implant placement. Purpose:The aim of the present clinical study was to determine evidence that synergy between 3D models and bone regeneration utilizing autologous fibroblast growth factor (FGF) and growth factors matrices mixed with demineralized freezedried bone allograft (DFDBA) particles optimize tissue engineering for immediate dental implant placement and loading during sinus lift procedure. Materials and methods:Twelve endo-osseous implants were placed into residual crestal bone (5.0 ± 0.15 mm). A minimal invasive osteotome Summer's technique was performed in combination with autologous FGF matrices mixed with FDBA particles. Soft tissue height and width were measured at baseline, 1, 3 and 6 months. Engineered bone surrounding implants was analyzed through 3D metric models for volume and contact interface from baseline to 6 months. Results:Healing was uneventful. The surgical guide and the osteotome technique significantly contribute to the initial implant stability. Gingival soft tissue improves in color and contour. Soft tissue height and width both increased from baseline to 6 months. At 1 month, soft tissue height (STH) increase was 2.55 ± 0.30 mm (CI 95%-p = 0.001), and soft tissue width (STW) gain was 1.50 ± 0.50 mm (p = 0.001-CI 95%). At 3 months, STH increased to 3.12 ± 0.50 mm and STW gain was 2.40 ± 0.40 mm (p = 0.001-CI 95%). At 6 months, these values remained stable. Implant sites receiving autologous FGF matrices mixed with DFDBA exhibited a BV gain of 0.47 ± 0.10 cm 3 -bone fill averaging 100% at 6 months (p = 0.001). Conclusion:The osteotome Summer`s technique was a predictable technique to increase bone volume. Autologous FGF matrices mixed with DFDBA favors 3D scaffold enhancing bioguided soft tissue gain and bone engineering at implant interface. Sinus membrane perforations were favorable controlled. Guided dental surgery and three-dimensional metric applications improve surgical placement, mechanical support, clinical performance and patient cost/benefit satisfaction. Further studies with a larger sample are needed to enhance the statistical significance of our clinical findings.

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Changes in Alveolar Bone Height and Width Following Post‐Extraction Ridge Augmentation Using a Fixed Bioabsorbable Membrane and Demineralized Freeze‐Dried Bone Osteoinductive Graft

Abstract: Results indicate a complete loss of augmented width 3 mm from the crest and almost complete loss in height and width 5 mm from the crest. Membrane stabilization appeared beneficial.

Cited by 108 publications

References 40 publications

Ridge preservation: what is it and when should it be considered

Ridge preservation: what is it and when should it be considered

Proteomic Analysis of Gingival Tissue and Alveolar Bone during Alveolar Bone Healing

Synergy between 3D Models and Tissue Engineering to Optimize Sinus Lift, Implant Placement and Immediate Loading in Partially Edentulous Patients

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