Changes in and Associations Among Functional Status and Perceived Quality of Life of Patients With Metastatic/Locally Advanced Cancer Receiving Rehabilitation for General Disability

Sekine, Ryuichi; Ogata, Masaru; Uchiyama, I; Miyakoshi, Koichi; Uruma, Megumi; Miyashita, Mitsunori; Morita, Tatsuya

doi:10.1177/1049909114537871

Cited by 25 publications

(16 citation statements)

References 34 publications

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“…Functional status reflects a person’s ability to perform routine tasks (e.g., mobility and self-care) and can affect a person’s QOL [86]. Functional status is not a surrogate for QOL because impaired function is not always associated with poorer QOL [87]. Across all three domains, both latent classes had relatively high KPS scores.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers

et al. 2016

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Purpose Not all oncology patients and their family caregivers (FCs) experience the same quality of life (QOL). The purposes of this study were to identify latent classes of oncology patients (n=168) and their FCs (n=85) with distinct physical, psychological, social, and spiritual well-being trajectories from prior to through four months after the completion of radiation therapy and to evaluate for demographic, clinical, and genetic characteristics that distinguished between these latent classes. Methods Using growth mixture modelling, two latent classes were found for three (i.e., physical, psychological, and social well-being) of the four QOL domains evaluated. Results Across these three domains, the largest percentage of participants reported relatively high well-being scores across the six months of the study. Across these three QOL domains, patients and FCs who were younger, female, belonged to an ethnic minority group, had children at home, had multiple comorbid conditions, or had a lower functional status were more likely to be classified in the lower QOL class. The social well-being domain was the only domain that had a polymorphism in nuclear factor kappa beta 2 (NFKB2) associated with latent class membership. Carrying one or two doses of the rare allele for rs7897947 was associated with a 52% decrease in the odds of belonging to the lower social well-being class (OR (95% CI) = .46 (.21, .99), p=.049). Conclusions These findings suggest that a number of phenotypic and molecular characteristics contribute to differences in QOL in oncology patients and their FCs.

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Section: Discussionmentioning

confidence: 99%

Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers

et al. 2016

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“…A small number of uncontrolled, prospective studies comparing outcomes before and after rehabilitation intervention, 55,56 as well as some randomized trials 57,58 show that general rehabilitation can improve function and QoL and reduce symptom burden (without worsening fatigue) in patients with cancer, even if the illness is at an advanced stage. 59,60 Salakari et al 61 performed a systematic review of 13 randomized trials published between 2009 and 2014 (1169 participants), evaluating the benefits of general rehabilitation among patients with advanced cancer; seven were limited to physical exercise alone. The review was suggestive of significant improvement in general well-being and QoL with physical exercise.…”

Section: Palliative Rehabilitationmentioning

confidence: 99%

Section: Evidence For Cancer Rehabilitationmentioning

confidence: 99%

Cancer Rehabilitation and Palliative Care—Exploring the Synergies

Chowdhury

Brennan

Gardiner

2020

Journal of Pain and Symptom Management

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With perpetual research, management refinement, and increasing survivorship, cancer care is steadily evolving into a chronic disease model. Rehabilitation physicians are quite accustomed to managing chronic conditions, yet, cancer rehabilitation remains unexplored. Palliative care physicians, along with rehabilitationists, are true generalists, who focus on the whole patient and their social context, in addition to the diseased organ system. This, together with palliative care's expertise in managing the panoply of troubling symptoms that beset patients with malignancy, makes them natural allies in the comprehensive management of this patient group from the moment of diagnosis. This article will explore the under-recognized and underused parallels and synergies between the two specialties as well as identifying potential challenges and areas for future growth.

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“…Rehabilitation, which includes caregiver education and training, optimizes patient function, reduces caregiver burden, and facilitates supported discharge home. 2,3,5 A growing body of evidence demonstrates that palliative rehabilitation can maintain and optimize functional ability. 5e8 Rehabilitation is highly valued by patients with advanced disease 4,9e11 and serves to improve patient confidence to actively participate in everyday activities.…”

Section: To the Editormentioning

confidence: 99%

“…4,12,13 It enables patients to regain hope through exerting control over valued activities, even in the face of progressive physical deterioration. 5,11,12 Psychosocial support during rehabilitation can be invaluable to facilitate adjustment to functional decline and enhance quality of life. 10e13…”

Section: To the Editormentioning

confidence: 99%