Changes in anterior and posterior corneal curvatures in keratoconus

Tomidokoro, Atsuo; Oshika, Tetsuro; Amano, Shiro; Higaki, Shiro; Maeda, Naoyuki; Miyata, Kazunori

doi:10.1016/s0161-6420(00)00159-7

Cited by 219 publications

(184 citation statements)

References 22 publications

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“…[14][15][16][20][21][22] Specifically, in keratoconus and also in keratoconus suspect, significantly larger values of BFS 14,16,21 and posterior elevation 15,16,22 have been reported (Figure 3). Schlegel et al 16 report a mean aconic astigmatism for the posterior corneal surface of 2.29 D G 1.71 (SD) in a sample of 48 keratoconussuspect patients using scanning-slit technology.…”

Section: Analysis Of the Posterior Corneal Surface In Keratoconusmentioning

confidence: 88%

“…There is evidence that both anterior and posterior curvatures are affected in keratoconic eyes and also in keratoconus suspect eyes. 20 Likewise, significantly larger values of best-fit sphere (BFS) 14,16,21 and posterior elevation 15,16,22 have been reported in clinical keratoconic eyes and keratoconus suspect eyes. Therefore, manifestations of the ectasia also occur at the posterior corneal surface, even in early stages of the disease.…”

Section: J Cataract Refract Surg 2012; 38:2167-2183 Q 2012 Ascrs and mentioning

confidence: 99%

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Characterization of corneal structure in keratoconus

Piñero¹,

Nieto²,

López-Miguel³

2012

Journal of Cataract and Refractive Surgery

142

113

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Section: Analysis Of the Posterior Corneal Surface In Keratoconusmentioning

confidence: 88%

Section: J Cataract Refract Surg 2012; 38:2167-2183 Q 2012 Ascrs and mentioning

confidence: 99%

Characterization of corneal structure in keratoconus

Piñero¹,

Nieto²,

López-Miguel³

2012

Journal of Cataract and Refractive Surgery

142

113

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“…Therefore evaluation of the anterior corneal surface in isolation can give indices that spuriously suggest the presence of keratoconus, and correlation with posterior corneal elevation maps and regional pachymetry is required. 20,21 The origin of the apparent anterior corneal elevation is uncertain, but the stromal deposits of MCD probably affect the quality of data capture.…”

Section: Discussionmentioning

confidence: 99%

Macular corneal dystrophy and associated corneal thinning

Ďuďáková

Palos

Svobodová

et al. 2014

Eye

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Purpose To identify the molecular genetic cause of macular corneal dystrophy (MCD) in four probands, and characterize phenotypic similarities between MCD and keratoconus. Methods We performed ophthalmological examination, Scheimpflug imaging (Pentacam, Oculus Inc.), histopathological examination of excised corneal buttons, and direct sequencing of the CHST6 coding region. Results Pentacam measurements were taken in six eyes of three probands. All showed diffuse corneal thinning with paracentral steepening of the anterior corneal surface that was graded as keratoconus by the integrated software, but without associated ectasia of the posterior corneal surface or regional thinning. Homozygous or compound heterozygous CHST6 mutations were identified in all cases, including two novel mutations, c.13C4T; p.(Arg5Cys) and c.289C4T; p.(Arg97Cys). Discussion Localized elevation of the anterior corneal curvature can occur in MCD in the absence of other features of keratoconus. The identification of a further two Czech probands with the compound allele c.[484C4G; 599T4G] supports the enrichment of this allele in the study population.

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“…Previous studies using videokeratography have quantitatively demonstrated that corneal irregular astigmatism is significantly greater in eyes with keratoconus than in normal eyes. [3][4][5][6] In addition, recent studies using wavefront analysis technology showed that ocular and corneal higher-order aberration, particularly coma aberration, is significantly increased in keratoconus. [7][8][9][10] Maeda et al 11 reported that corneal topographic indices significantly correlated with letter-contrast sensitivity in eyes with keratoconus.…”

Section: Introductionmentioning

confidence: 99%

Higher-order wavefront aberration and letter-contrast sensitivity in keratoconus

Okamoto

Samejima

et al. 2007

Eye

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Aims To evaluate the relation between higher-order aberration of the eye and contrast sensitivity function in eyes with keratoconus. Methods In 22 eyes of 14 patients with keratoconus (age 30.578.4 years, means7SD) and 26 eyes of 13 normal controls (age 29.276.7 years), ocular higher-order wavefront aberration for a 6-mm pupil was measured with the Hartmann-Schack aberrometer (KR-9000 PW, Topcon). The root mean square (RMS) of third-and fourth-order Zernike coefficients was used to represent higher-order aberrations. The letter-contrast sensitivity was examined using the CSV-1000LV contrast chart (Vector Vision). Results In the keratoconus group, the letter-contrast sensitivity showed significant correlation with third-order (Spearman's correlation coefficient r ¼ À0.736, Po0.001) and fourth-order aberrations (r ¼ À0.464, Po0.05). There was borderline correlation between log MAR BSCVA and third-order (r ¼ 0.413, P ¼ 0.070) and fourth-order aberrations (r ¼ 0.394, P ¼ 0.086). In the normal group, the letter-contrast sensitivity had no significant correlation with third-order (r ¼ À0.170, P ¼ 0.411) and fourth-order aberrations (r ¼ À0.088, P ¼ 0.673), and log MAR best spectacle-corrected visual acuity (BSCVA) showed no correlation with third-order (r ¼ 0.063, P ¼ 0.762) and fourth-order aberrations (r ¼ À0.282, P ¼ 0.165). Conclusions In eyes with keratoconus, there is significant correlation between contrast sensitivity and ocular higher-order wavefront aberrations.

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Changes in anterior and posterior corneal curvatures in keratoconus

Cited by 219 publications

References 22 publications

Characterization of corneal structure in keratoconus

Characterization of corneal structure in keratoconus

Macular corneal dystrophy and associated corneal thinning

Higher-order wavefront aberration and letter-contrast sensitivity in keratoconus

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