Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development

Yuan, Yushan; Chen, Peng; Liu, Ying; Cheng, Jiaheng; Yan, Xia; Luo, Chenglong; Shu, Dingming; Qu, Hao; Ji, Jian

doi:10.1016/j.psj.2022.102267

Cited by 4 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides the parameters of AUC 0–∞ and C max , which showed no significant variance, all the other pharmacokinetic parameters revealed statistically significant differences between both combined groups ( Table 3 ). Although in this research, we have not explored the elimination route of florfenicol in poultry, it is known that medications and gut microbiota have a potential interaction that can affect drug pharmacokinetics ( Yuan et al., 2023 ). Specifically, COS has been reported to promote the growth of certain beneficial gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Effects of chitooligosaccharide on the in vitro antibacterial activity against avian Escherichia coli and the pharmacokinetics of florfenicol in healthy chickens

Zhang,

Li,

Duan

et al. 2024

Poultry Science

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Effects of chitooligosaccharide on the in vitro antibacterial activity against avian Escherichia coli and the pharmacokinetics of florfenicol in healthy chickens

Zhang,

Li,

Duan

et al. 2024

Poultry Science

View full text Add to dashboard Cite

“…Consequently, the advancement of modern animal husbandry urgently requires alternatives to antibiotics to preserve livestock health and improve feed conversion efficiency. Natural plant extracts emerge as a solution to the misuse of antibiotics in aquaculture, offering unique benefits (Yuan et al, 2023). Allicin, a natural plant additive, is an oily substance produced by the catalytic action of allinase on allicin cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of Allicin on the Immune Performance and Expression of Immune-related Genes in Muchuan Black-bone Chickens

Liao,

Shen,

et al. 2024

IJAR

View full text Add to dashboard Cite

Background: In response to China’s ban on medicinal feed additives with growth-promoting functions in livestock and poultry feed, there is an urgent need in modern animal husbandry for alternatives to antibiotics to sustain livestock health and improve feed conversion efficiency. Allicin, known for its safety, efficiency, lack of drug resistance and absence of residue, regulates the intestinal flora structure; inhibits the growth of harmful bacteria; improves intestinal health, immunity and stress resistance; and improves animal production. Methods: To investigate the impact of allicin on immune performance and immune-related gene expression in Muchuan black-bone chickens, diets were supplemented with varying allicin levels (50, 100, 200 mg/kg), designated as test groups A, B and C, respectively. Initially, growth performance was assessed. Subsequently, immunoglobulins were measured via enzyme-linked immunosorbent assay (ELISA) and colorimetry; immune titers for avian influenza and Newcastle disease were evaluated using hemagglutination and hemagglutination inhibition tests and the expression of immune genes was analyzed via real-time quantitative PCR. Finally, serum biochemical indices in each group were determined. Result: Compared to the control group, allicin supplementation resulted in increased average fasting body weight in the experimental group and significantly (P less than 0.05) higher thymus and musogastric indices in groups A and C, respectively. Serum levels of immunoglobulin M in groups A and B and immunoglobulin G levels were significantly higher in all experimental groups than in controls. Antibody titers against avian influenza H5 and H7 strains were higher in all test groups, with Newcastle disease antibody titers in groups B and C significantly higher than those in controls. The mRNA expression levels of IFN-ã were lower across all experimental groups, whereas the expression levels of TLR3 in groups B and C and TLR15 in group B were higher. Serum levels of triglycerides in group A were significantly higher and blood urea nitrogen levels were significantly lower in groups B and C than in controls. These findings indicate that dietary allicin (50-200 mg/kg) significantly improves growth performance, immunity and protein and lipid metabolism in Muchuan black-bone chickens, offering valuable data for the development and use of allicin as an antibiotic alternative.

show abstract

Protective effects of maternal administration of total saponins of Codonopsis pilosula in the mice offspring following diarrhea: role of immune function, antioxidant function, and intestinal inflammatory injury

Li,

Sun,

Yang

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development

Cited by 4 publications

References 42 publications

Effects of chitooligosaccharide on the in vitro antibacterial activity against avian Escherichia coli and the pharmacokinetics of florfenicol in healthy chickens

Effects of chitooligosaccharide on the in vitro antibacterial activity against avian Escherichia coli and the pharmacokinetics of florfenicol in healthy chickens

Effects of Allicin on the Immune Performance and Expression of Immune-related Genes in Muchuan Black-bone Chickens

Protective effects of maternal administration of total saponins of Codonopsis pilosula in the mice offspring following diarrhea: role of immune function, antioxidant function, and intestinal inflammatory injury

Contact Info

Product

Resources

About