Changes in Antigen Expression in a Follow-up of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

CD markers variations in chronic lymphocytic leukemia: New insights into prognosis

“…Both isotypes can be expressed on B-cells, but CD23a expression levels may be higher than CD23b in CLL patients (Kriston et al, 2017). Studies have indicated that the expression levels of CD23 in CLL patients can be inversely related to the stage of disease, absolute lymphocyte counts, and infiltration of BM, so that the reduction of CD23 expression can be observed in patients with high lymphocyte counts, advanced stages, high infiltration of BM by lymphocytes, and poor clinical course (Jurisic et al, 2008;Zhou, Tewari, Nassiri, & Czader, 2015). Furthermore, reduced CD23 expression can be associated with other poor prognostic factors (Table 1).…”

“…CD49d is an adhesion molecule expressed on the surface of B lymphocytes (Popova, Blazheva, Lukanov, Naneva, & Tzvetkov, 2018), which can play a vital role in regulating cell-cell and cell-extracellular matrix interactions by binding to fibronectin and vascular cell adhesion molecule 1 (VCAM-1) in BM or GC (Hjalmar et al, 2002;Jurisic et al, 2005;Zhou et al, 2015). Increasing CD49d expression in Binet A CLL patients can be associated with reduced survival and poor response to treatment in these patients (Nuckel et al, 2009;Rossi et al, 2008).…”