Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period

Abstract

Over the past three decades, antimicrobial resistance in Streptococcus pneumoniae has dramatically increased worldwide. Non-susceptibility to penicillin in S. pneumoniae was first described in Australia in 1967, and later in New Guinea (1974), South Africa (1977), and Spain (1979). Most of these strains showed resistance to multiple antibiotics and belonged to serotypes 6A, 6B, 19A, 19F, and 23F. By the late 1980s and 1990s, the emergence and rapid dissemination of antibiotic-resistant pneumococci was observed in southern and eastern Europe, North America, South America, Africa, and Asia. Great geographical variability, both in serotype distribution and in the prevalence of resistant pneumococci, has been reported. However, the highest rates of resistance to penicillin and erythromycin worldwide were found in serotypes 6B, 6A, 9V, 14, 15A, 19F, 19A, and 23F. The introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) in the 2000s and a reduction in antimicrobial use were associated with a significant decline in the incidence of invasive pneumococcal infections and in rates of antibiotic resistance in the USA. However, an increase in the incidence of infections caused by non-PCV7 serotypes, especially multiresistant serotype 19A pneumococci, has been observed in many countries over the last 5 years. The dynamic character of serotypes and antibiotic resistance in S. pneumoniae should be controlled by a policy of prudent antibiotic use and by implementation of the new generation of conjugate vaccines.

Cost-effectiveness analysis of pneumococcal polysaccharide vaccination from age 60 in São Paulo State, Brazil

“…9 Moreover in the US, an increase in the isolation of antibiotic resistant 19A strains has been reported, a strain associated with increased incidence of IPD. 10 Effective immunization against S. pneumoniae is the most effective method to reduce the impact of pneumococcal infections, including those caused by antibiotic resistant strains. Therefore, physicians and policy-makers have high expectations concerning the value of pneumococcal vaccination of the adults and elderly.…”

Vaccines for the elderly need to be introduced into the immunization program in India

“…Those >60 y are at a significant higher risk for worse outcomes of an episode of pneumococcal disease, with higher chances of development of complications. 6 Globally, pneumococcal disease accounts for the largest number of cases of vaccine-preventable morbidity and mortality. The US Centers for Disease Control and Prevention (CDC) recommends that all elderly should receive a single dose of pneumococcal polysaccharide vaccine.…”

Nasopharyngeal Carriage of Streptococcus pneumoniae in orphans, preschool children and unorganized children under 5 years

“…[45]. Таким образом, в последние годы в России зна-чительно увеличилось число штаммов, имеющих сразу 2 механизма резистентности к макролидам, что вызы-вает обеспокоенность, т. к. этот фенотип связан с генети-ческими элементами клональных комплексов наиболее резистентных пневмококков [46].…”