Changes in antimicrobial susceptibility in a population of Escherichia coli isolated from feedlot cattle administered ceftiofur crystalline-free acid

Lowrance, T. Courtney; Loneragan, Guy H.; Kunze, David J.; Platt, Tammy M.; Ives, Samuel E.; Scott, H. M.; Norby, Bo; Echeverry, Alejandro; Brashears, Mindy M.

doi:10.2460/ajvr.68.5.501

Cited by 75 publications

(101 citation statements)

References 20 publications

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“…5). Longitudinal studies have shown a transient increase of ceftiofur-resistant enteric bacteria during treatment (Lowrance et al, 2007). The pharmacokinetic and pharmacodynamic parameters influenced the selection of antimicrobial resistance during treatment, but fitness cost highly determined the persistence of the resistant bacteria after the end of treatment.…”

Section: Transmission Modelingmentioning

confidence: 99%

Mathematical Modeling of the Transmission and Control of Foodborne Pathogens and Antimicrobial Resistance at Preharvest

Lanzas

Gröhn

2011

Foodborne Pathogens and Disease

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Foodborne diseases are a significant health-care and economic burden. Most foodborne pathogens are enteric pathogens harbored in the gastrointestinal tract of farm animals. Understanding the transmission of foodborne pathogens and the dissemination of antimicrobial resistance at the farm level is necessary to design effective control strategies at preharvest. Mathematical models improve our understanding of pathogen dynamics by providing a theoretical framework in which factors affecting transmission and control of the pathogens can be explicitly considered. In this review, we aim to present the principles underlying the mathematical modeling of foodborne pathogens and antimicrobial resistance at the farm level to a broader audience.

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Section: Transmission Modelingmentioning

confidence: 99%

Mathematical Modeling of the Transmission and Control of Foodborne Pathogens and Antimicrobial Resistance at Preharvest

Lanzas

Gröhn

2011

Foodborne Pathogens and Disease

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“…Experimentally administration of ceftiofur to feedlot cattle was also associated with an increase in the population of ceftiofur-resistant isolates (Lowrance et al, 2007). It has been argued that active concentrations of ceftiofur and cefquinome in the intestines of treated animals are very low, as they are mainly excreted in urine with a limited portion, excreted in faeces (Hornish and Kotarski, 2002); see also MRL summary reports available at www.ema.europa.eu).…”

Section: Impact Of Cephalosporin Use On Selection and Amplification Omentioning

confidence: 99%

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

246

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The potential contribution of food-producing animals or foods to public health risks by ESBL and/or AmpCproducing bacteria is related to specific plasmid-mediated ESBL and/or AmpC genes encoded by a number of organisms. The predominant ESBL families encountered are CTX-M, TEM, and SHV; the predominant AmpCfamily is CMY. The most common genes associated with this resistance in animals are bla CTX-M-1 (the most commonly identified ESBL), and bla CTX-M-14 , followed by bla and bla Among the genes encoding AmpC-type β-lactamases, bla CMY-2 is the most common.The bacterial species most commonly identified with these genes are Escherichia coli and non-typhoidal Salmonella. ESBL/AmpC transmission is mainly driven by integrons, insertion sequences, transposons and plasmids, some of which are homologous in isolates from both food-production animals and humans. Cefotaxime is used as the drug of choice for optimum detection of bla ESBL and/or bla AmpC genes. The preferred method for isolation of ESBL-and/or AmpC-producers is screening on selective agar preceded by selective enrichment in a broth.The establishment of risk factors for occurrence of ESBL/AmpC-producing bacteria is particularly complicated by the data unavailability or lack of its accuracy. The use of antimicrobials is a risk factor for the selection and spread of resistant clones, resistance genes and plasmids. Since most ESBL-and AmpC-producing strains carry additional resistances to other commonly-used veterinary drugs, generic antimicrobial use is a risk factor for ESBL/AmpC and it is not restricted specifically to the use of cephalosporins. An additional risk factor is extensive trade of animals in EU MS. There are no data on the comparative efficiency of individual control options in reducing public health risks caused by ESBL and/or AmpC-producing bacteria related to food-producing animals. Prioritisation is complex, but it is considered that a highly effective control option would be to stop all uses of cephalosporins/systemically active 3 rd /4 th generation cephalosporins, or to restrict their use (use only allowed under specific circumstances). As co-resistance is an important issue, it is also of high priority to decrease the total antimicrobial use in animal production in the EU. KEY WORDSResistance, ESBLs, AmpC, occurrence, transmission, control options, public health microbiology. SUMMARYFollowing a request from the European Commission, the Panel on Biological Hazards (BIOHAZ) was asked to deliver a Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum beta (β)-lactamases (ESBL) and/or AmpC β-lactamases (AmpC) in food and foodproducing animals. In particular, the Panel was asked: (i) to propose a definition of the ESBL-and/or AmpC-producing bacterial strains and genes relevant for public health and linked to food-producing animals or food borne transmission; (ii) to review the information on the epidemiology of acquired resistance to broad spectrum cephalosporins including the genes coding for ...

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“…Calves administered intramuscular (IM) ceftiofur hydrochloride had a significantly increased number of ceftriaxoneresistant fecal bacteria following treatment (Jiang et al, 2006). Cattle administered ceftiofur crystalline-free acid had a 2-week increase in multidrug-resistant (ceftiofur, ampicillin, chloramphenicol, tetracycline, and sulfisoxazole) Escherichia coli (Lowrance et al, 2007).…”

Section: Chapter 1 -Introduction Literature Reviewmentioning

confidence: 99%

Effect of cefovecin on the fecal flora of healthy dogs

Lawrence

KuKanich

et al. 2013

The Veterinary Journal

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Cefovecin is an extended-spectrum long-acting third generation cephalosporin used to treat canine infections. The study objective was to determine the effect of cefovecin on the absolute number and antimicrobial susceptibility of fecal enteric bacteria in healthy dogs.Fourteen Beagles were randomly assigned to a treated (n = 7, 8 mg/kg cefovecin subcutaneously on day 1) or untreated (n = 7) group. LC/MS was used to determine plasma cefovecin concentration on day 14. E. coli, enterococci, and Salmonella were isolated and enumerated from fecal samples collected on days 0, 3, 7, 14, and 28. Antimicrobial resistance was determined using disc diffusion, MIC, and detected using PCR for the bla CMY-2 gene on select isolates.Mean plasma concentration of cefovecin on day 14 was 9.59 µg/mL in treated dogs; untreated dogs had no measurable plasma cefovecin. The absolute number of E. coli was lower in treated dogs on day 3 (P ≤ 0.0001), and the absolute number of cefovecin-resistant E. coli was higher in treated dogs on days 7 (P = 0.002), 14 (P = 0.004) and 28 (P ≤ 0.0001), compared to untreated dogs. Enterococci increased and were higher in the treatment group on day 7 (P = 0.0226). Isolation of Salmonella was rare. After cefovecin treatment, beta-lactam resistance was more common in fecal E. coli from treated dogs than untreated dogs, while resistance of enterococci was not altered. On day 28, treated dogs were 3.25 times more likely to carry the bla CMY-2 gene than untreated dogs (95% CI 1.27 -8.35). The implications of these findings in clinically ill patients require further research.iii

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Changes in antimicrobial susceptibility in a population of Escherichia coli isolated from feedlot cattle administered ceftiofur crystalline-free acid

Abstract: Administration of CCFA provided selection pressure that favored transient expansion of multiple-resistant variants.

Cited by 75 publications

References 20 publications

Mathematical Modeling of the Transmission and Control of Foodborne Pathogens and Antimicrobial Resistance at Preharvest

Mathematical Modeling of the Transmission and Control of Foodborne Pathogens and Antimicrobial Resistance at Preharvest

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Effect of cefovecin on the fecal flora of healthy dogs

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