Changes in anxiety sensitivity with pharmacotherapy for panic disorder

Simon, Naomi M.; Otto, Michael W.; Smits, Jasper A.J.; Nicolaou, D. Colette; Reese, Hannah E.; Pollack, Mark H.

doi:10.1016/j.jpsychires.2004.01.004

Cited by 31 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Catastrophic cognitions that occur during a panic attack are known to strongly affect a fear of anxiety sensations, and one of the most observable panic symptoms, 'fear of dying', is most related to anxiety sensitivity 30. A previous study showed that changes of anxiety sensitivity may be an important factor predicting treatment response in panic disorder 31. However, in this study, there were no differences in reduction of anxiety sensitivity between the two subtypes.…”

Section: Discussioncontrasting

confidence: 70%

Clinical Characteristics of the Respiratory Subtype in Panic Disorder Patients

Song

Kim

Heo

et al. 2014

Psychiatry Investig

View full text Add to dashboard Cite

ObjectivePanic disorder has been suggested to be divided into the respiratory and non-respiratory subtypes in terms of its clinical presentations. The present study aimed to investigate whether there are any differences in treatment response and clinical characteristics between the respiratory and non-respiratory subtypes of panic disorder patients.MethodsAmong the 48 patients those who completed the study, 25 panic disorder patients were classified as the respiratory subtype, whereas 23 panic disorder patients were classified as the non-respiratory subtype. All patients were treated with escitalopram or paroxetine for 12 weeks. We measured clinical and psychological characteristics before and after pharmacotherapy using the Panic Disorder Severity Scale (PDSS), Albany Panic and Phobic Questionnaire (APPQ), Anxiety Sensitivity Index-Revised (ASI-R), State-Trait Anxiety Inventory (STAI-T, STAI-S), Hamilton Anxiety Rating Scale (HAM-A), and Hamilton Depression Rating Scale (HAM-D).ResultsThe prevalence of the agoraphobia was significantly higher in the respiratory group than the non-respiratory group although there were no differences in gender and medication between the two groups. The respiratory group showed higher scores on the fear of respiratory symptoms of the ASI-R. In addition, after pharmacotherapy, the respiratory group showed more improvement in panic symptoms than the non-respiratory group.ConclusionPanic disorder patients with the respiratory subtype showed more severe clinical presentations, but a greater treatment response to SSRIs than those with non-respiratory subtype. Thus, classification of panic disorder patients as respiratory and non-respiratory subtypes may be useful to predict clinical course and treatment response to SSRIs.

show abstract

Section: Discussioncontrasting

confidence: 70%

Clinical Characteristics of the Respiratory Subtype in Panic Disorder Patients

Song

Kim

Heo

et al. 2014

Psychiatry Investig

View full text Add to dashboard Cite

show abstract

“…Other CBT methods to improve sleep aim at improving sleep hygiene and reducing related cognitive distortions (Edinger & Carney, 2008;Siebern & Manber, 2010). Pharmacotherapy can also effectively target insomnia (Sullivan, 2010) and has also been shown to decrease anxiety sensitivity; for example, paroxetine and clonazepam decreased AS in patients with panic disorder (Simon et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

The role of anxiety sensitivity in sleep disturbance in panic disorder

Hoge

Marques

Wechsler

et al. 2011

Journal of Anxiety Disorders

View full text Add to dashboard Cite

“…Although prior research has shown that pharmacotherapy leads to significant acute reductions in AS in panic disorder [Simon et al, 2004], the impact of pharmacotherapy on AS in other anxiety conditions is less clear. Our findings suggest that fluoxetine pharmacotherapy reduces general excessive fear of anxiety-related sensations in GAD patients.…”

Section: Discussionmentioning

confidence: 96%

Examination of the decline in symptoms of anxiety and depression in generalized anxiety disorder: impact of anxiety sensitivity on response to pharmacotherapy

et al. 2008

Self Cite

View full text Add to dashboard Cite

Pharmacotherapy is an effective treatment for generalized anxiety disorder (GAD), but few studies have examined the nature of decline of anxiety and depression during pharmacotherapy for GAD and even fewer studies have examined predictors of symptom decline. This study examined the decline in symptoms of anxiety and depression in patients with GAD during a 6-week open trial of fluoxetine. Growth curve analyses indicated that pharmacotherapy with fluoxetine led to significant declines in symptoms of anxiety and depression over the 6 weeks of treatment. However, the decay slope observed for anxiety symptoms was significantly greater than that for depressive symptoms. Further analyses revealed that the decline in anxiety remained significant after accounting for the changes in symptoms of depression. However, the effect of treatment on depression was no longer significant after controlling for the reduction in anxiety symptoms. Overall anxiety sensitivity (AS) did not moderate the level of reduction in symptoms of anxiety or depression during pharmacotherapy. However, AS specific to physical concerns demonstated a marginal negative association with decline in anxiety and depression. AS specific to social concerns also demonstrated a marginal negative association with decline in anxiety symptoms. These findings suggest that the decline in anxiety symptoms is independent of the decline in symptoms of depression during pharmacotherapy for GAD and specific AS dimensions may predict symptom change in GAD.

show abstract

Changes in anxiety sensitivity with pharmacotherapy for panic disorder

Cited by 31 publications

References 25 publications

Clinical Characteristics of the Respiratory Subtype in Panic Disorder Patients

Clinical Characteristics of the Respiratory Subtype in Panic Disorder Patients

The role of anxiety sensitivity in sleep disturbance in panic disorder

Examination of the decline in symptoms of anxiety and depression in generalized anxiety disorder: impact of anxiety sensitivity on response to pharmacotherapy

Contact Info

Product

Resources

About