Changes in Autonomic Control of Heart Associated with Classical Appetitive Conditioning in Rats

Inagaki, Hideaki; Kuwahara, Masayoshi; Tsubone, Hirokazu

doi:10.1538/expanim.54.61

Cited by 16 publications

(22 citation statements)

References 23 publications

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“…Human studies show that psychosocial stress leads to sympathetic dominance and reduced HRV [88]. A handful of rodent studies similarly support this observation with psychological stressors [89][90][91][92][93][94][95][96][97][98]. For example, Sprague-Dawley rats exposed to chronic mild stress exhibited a stable increase in HR, concomitant with a decrease in HRV, and those rats with lowered HRV were more vulnerable to experimentally-induced cardiac arrhythmias [98].…”

Section: Prognostic Value Of Hrv In Rodentsmentioning

confidence: 88%

Heart rate variability in rodents: uses and caveats in toxicological studies

et al. 2007

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Heart rate variability (HRV) is a measure of cardiac pacing dynamics that has recently garnered a great deal of interest in environmental health studies. While the use of these measures has become popular, much uncertainty remains in the interpretation of results, both in terms of human and animal research. In humans, HRV endpoints, specifically chronic alterations in baseline HRV patterns, have been reasonably well characterized as prognostic indicators of adverse outcomes for a variety of diseases. However, such information is lacking for reversible HRV changes that may be induced by short-term exposures to environmental toxicants. Furthermore, there are minimal substantive data, either acute or chronic, regarding the pathological interpretation or prognostic value of toxicant-induced changes in HRV in rodents. The present report summarizes the physiological and clinical aspects of HRV, the methodological processes for obtaining these endpoints, and previous human and animal studies in the field of environmental health. Furthermore, we include a discussion of important caveats and recommendations for the interpretation of HRV data in animal research.

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Section: Prognostic Value Of Hrv In Rodentsmentioning

confidence: 88%

Heart rate variability in rodents: uses and caveats in toxicological studies

et al. 2007

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“…We found two lines of research in the literature assessing autonomic nervoussystem activity in humans and animals: those that tested rewarding stimuli and those that tested aversive stimuli. [32][33][34][35] To illustrate, rewarding events have been shown to increase subjects' heart rates significantly. 32 Firestone and Douglas (1975) manipulated reward, punishment, and reward plus punishment separately in three conditions, and tested the subjects' SC and heart rate.…”

Section: Discussionmentioning

confidence: 99%

“…[32][33][34][35] To illustrate, rewarding events have been shown to increase subjects' heart rates significantly. 32 Firestone and Douglas (1975) manipulated reward, punishment, and reward plus punishment separately in three conditions, and tested the subjects' SC and heart rate. Although there was no significant difference in SC amongst the groups, they found that heart-rate response was greater in the reward condition than in the other two groups.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of Internet Addiction Risk Level Based on Autonomic Nervous Responses: The Internet-Addiction Hypothesis of Autonomic Activity

Wang

Huang

2010

Cyberpsychology, Behavior, and Social Networking

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How high-risk Internet addiction (IA) abusers respond to different autonomic nervous activities compared with low-risk subjects may be a critical research goal with prevention and treatment implications. The aim of the present study was to address this issue by observing differences between high- and low-risk IA abusers in four physiological assessments when surfing the Internet: blood volume pulse (BVP), skin conductance (SC), peripheral temperature (PTEMP), and respiratory response (RESPR). Forty-two male and ten female participants aged 18-24 years were screened with the Chen Internet Addiction Scale (CIAS, 2003), and then separated into high- and low-risk IA groups. Using psychophysiology equipment, participants encountered a 3-minute adaptation period followed by a 6-minute testing period for surfing the Internet on baseline and testing phases. The present results indicate that: (a) the CIAS scores were positively and negatively correlated with the RESPR and the PTEMP; (b) the PTEMP and RESPR of high-risk IA abusers were respectively weaker and stronger than those of low-risk IA abusers; the BVP and SC of high-risk IA abusers were respectively augmented and decreased relative to low-risk IA abusers. Thus we suggest that four autonomic responses may be differentially sensitive to abusers' potency in terms of the IA hypothesis of autonomic activity. The stronger BVP and RESPR responses and the weaker PTEMP reactions of the high-risk IA abusers indicate the sympathetic nervous system was heavily activated in these individuals. However, SC activates parasympathetic responses at the same time in the high-risk IA abusers. The paradoxical responses between the sympathetic and parasympathetic actions are addressed in the discussion.

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“…There are several reports that suggest the usefulness of HRV in studying psychological stresses [5,16,31], classical conditioning [10], emotional regulation controlled by the limbic system [29], and prefrontal cognitive function [6,8].…”

mentioning

confidence: 99%

The Evaluation of Autonomic Nervous System Activation during Learning in Rhesus Macaques with the Analysis of the Heart Rate Variability

2007

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ABSTRACT. The aims of this study were to measure the activity of the autonomic nervous system using heart rate variability (HRV) during learning tasks and to clarify the relationship between learning to overcome a difficult situation and the autonomic nervous system in monkeys. Two young male monkeys (Macaca mulatta) were given simple discrimination learning tasks (DL) and delayed matching to samples tasks (DMTS); Holter-type electrocardiography was done, and HRV was measured. We defined the frequency bands of HRV in rhesus macaques; the low frequency (LF) was 0.01-0.15 Hz, and the high frequency (HF) was 0.15-0.50 Hz. Based on these frequency bands, the LF/HF ratios during learning tasks were analyzed, and a significant increase in the ratio was found during the tasks. The variances in the HF differed between the DL and DMTS tasks; during DMTS tasks, HF variances had a tendency to increase. Our results indicate that increased sympathetic activity accompanied learning and suggest that the parasympathetic nervous system plays a key role during learning, particularly when difficult tasks are being learned. KEY WORDS: autonomic nervous system, heart rate variability, holter-type electrocardiography, learning tasks, rhesus macaque (Macaca mulatta).

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Changes in Autonomic Control of Heart Associated with Classical Appetitive Conditioning in Rats

Cited by 16 publications

References 23 publications

Heart rate variability in rodents: uses and caveats in toxicological studies

Heart rate variability in rodents: uses and caveats in toxicological studies

Differentiation of Internet Addiction Risk Level Based on Autonomic Nervous Responses: The Internet-Addiction Hypothesis of Autonomic Activity

The Evaluation of Autonomic Nervous System Activation during Learning in Rhesus Macaques with the Analysis of the Heart Rate Variability

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