Changes in Bacterial Enzyme Patterns, Drug Susceptibility and Chemotherapy Through Enzyme Blocking Agents

Seneca, Harry; Lattimer, John K.; Zinsser, Hans; Donovan, Jerry; Peer, P.; Stuart, P

doi:10.1016/s0022-5347(17)64987-5

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Clinicolaboratory Classification Of Pathogens According To U1

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1967

1986

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“…It was further demonstrated in vitro and in vivo (patients) that chlormerodrin and RO 5-2795 altered the drug susceptibilityjresistance pattern of uropathogens, thus making them more susceptible to the action of antibacterials or antibiotics. Unfortunately, in some instances, organomcrcurials had the adverse effect of rendering the pathogens more drug-resistant (17,(22)(23)(24). Table 1 shows the change in the enzyme patterns (urease, citrase), the carbohydrate fermentation reactions, and the drug susceptibility of pathogens in patients following the administration of organomercurials.…”

Section: Clinicolaboratory Classification Of Pathogens According To Umentioning

confidence: 99%

Bacterial Mutation and the Evolution of Drug Resistance in Relation to Chemotherapy*

Seneca

1967

J American Geriatrics Society

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Section: Clinicolaboratory Classification Of Pathogens According To Umentioning

confidence: 99%

Bacterial Mutation and the Evolution of Drug Resistance in Relation to Chemotherapy*

Seneca

1967

J American Geriatrics Society

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Urinary Calculi: Microbiological and Crystallographic Studies

Rosenstein

Griffith

1986

CRC Critical Reviews in Clinical Laboratory Sciences

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Although referred to as "urinary calculus disease", the formation of stone in the urinary tract is not caused by a single etiological agent. As such, diverse clinical investigations to diagnose the cause of stone formation must be carried out and the course of management after diagnosis must inevitably be different in each case. This review will cover all aspects of calculus formation, but will give particular attention to calculi caused by infection of the urinary tract with urease-producing bacteria. This is a recurrent, potentially life-threatening disease which has led clinicians to refer to the condition as "stone cancer". Because the etiology of infection stones is so different from stones caused by metabolic disorders, the two disease patterns should be considered separately, a fact often overlooked in epidemiological studies of stone formation. The importance of analysis of calculi as an aid to management is thus emphasized; identification of stone type will help to indicate appropriate therapy. A review of methods of analysis will be covered, particularly crystallographic analysis. Inhibition of bacterial urease as a means of management of infection stones will be discussed together with problems encountered and brighter hopes for the future.

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Changes in Bacterial Enzyme Patterns, Drug Susceptibility and Chemotherapy Through Enzyme Blocking Agents

Cited by 2 publications

References 3 publications

Bacterial Mutation and the Evolution of Drug Resistance in Relation to Chemotherapy*

Bacterial Mutation and the Evolution of Drug Resistance in Relation to Chemotherapy*

Urinary Calculi: Microbiological and Crystallographic Studies

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