Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice

Yamamoto, Yuta; Tanahashi, Takao; Kawai, Tomoko; Chikahisa, Sachiko; Katsuura, Sakurako; Nishida, Kensei; Teshima-Kondo, Shigetada; Séi, Hiroyoshi; Rokutan, Kazuhito

doi:10.1152/physiolgenomics.00082.2009

Cited by 60 publications

(61 citation statements)

References 45 publications

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“…In an activity box, CR mice did not show increased distance traveled per minute over a 1 h period (AL ¼ 111.1 ± 2.8 cm, CR 111.8 ± 2.4 cm, and n ¼ 15,15, NS). These results are consistent with previous studies showing no increase in activity with CR in C57BL/6 mice (Gelegen et al, 2007;Yamamoto et al, 2009). …”

Section: Cr Does Not Increase General Activitysupporting

confidence: 94%

“…Mice were weighed and fed daily within 2 h of onset of dark cycle. Mice undergoing CR received 60% of the AL group's previous day's consumption as described (Yamamoto et al, 2009). Adolescent mice began CR between days P36 and P38.…”

Section: Animalsmentioning

confidence: 99%

“…For each trial, the mouse was placed on the central platform facing an open arm and behavior recorded for 5 min and analyzed using Ethovision XT software (Noldus) (Yamamoto et al, 2009). …”

Section: Elevated Plus Mazementioning

confidence: 99%

“…CR reduced the body weight to about 80% of AL-fed mice (CR mean 13.0±0.3, AL mean 16.2±0.8, po0.01). Behavioral testing was begun after 8 days of CR as previous work has reported maximal anxiolytic effect of CR at this time (Yamamoto et al, 2009). Mice were fear conditioned followed by 2 days of fear extinction training.…”

Section: Cr Enhances Fear Extinction Learningmentioning

confidence: 99%

“…CR has SSRI-like anxiolytic properties in mice that may also be due to enhanced neural plasticity and fear extinction learning (Yamamoto et al, 2009). In the visual system CR enhances neural plasticity in a manner similar to SSRI's.…”

Section: Introductionmentioning

confidence: 99%

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Caloric Restriction Enhances Fear Extinction Learning in Mice

Riddle

McKenna

Yoon

et al. 2013

Neuropsychopharmacol

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Fear extinction learning, the ability to reassess a learned cue of danger as safe when it no longer predicts aversive events, is often dysregulated in anxiety disorders. Selective serotonin reuptake inhibitors (SSRI's) enhance neural plasticity and their ability to enhance fear extinction learning may explain their anxiolytic properties. Caloric restriction (CR) has SSRI-like effects on neural plasticity and anxiety-related behavior. We implemented CR in mice to determine its effects on conditioned-fear responses. Wild type and serotonin transporter (SERT) knockout mice underwent CR for 7 days leading to significant weight loss. Mice were then tested for cued fear learning and anxiety-related behavior. CR markedly enhanced fear extinction learning and its retention in adolescent female mice, and adults of both sexes. These effects of CR were absent in SERT knockout mice. Moreover, CR phenocopied behavioral and molecular effects of chronic fluoxetine, but there was no additive effect of CR in fluoxetine-treated mice. These results demonstrate that CR enhances fear extinction learning through a SERT-dependent mechanism. These results may have implications for eating disorders such as anorexia nervosa (AN), in which there is a high prevalence of anxiety before the onset of dietary restriction and support proposals that in AN, CR is a motivated effort to control dysregulated fear responses and elevated anxiety.

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Section: Cr Does Not Increase General Activitysupporting

confidence: 94%

Section: Animalsmentioning

confidence: 99%

“…For each trial, the mouse was placed on the central platform facing an open arm and behavior recorded for 5 min and analyzed using Ethovision XT software (Noldus) (Yamamoto et al, 2009). …”

Section: Elevated Plus Mazementioning

confidence: 99%

Section: Cr Enhances Fear Extinction Learningmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Caloric Restriction Enhances Fear Extinction Learning in Mice

Riddle

McKenna

Yoon

et al. 2013

Neuropsychopharmacol

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Cardiac and vascular gene profiles in an animal model of takotsubo cardiomyopathy

et al. 2010

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We investigated cardiac and vascular gene profiles in response to immobilization stress (IMO) in rats, an animal model of emotional stress-induced takotsubo cardiomyopathy using microarray analysis, followed by re-confirmation with real-time reverse transcription-polymerase chain reaction. Expression levels of the identified genes were further estimated by pretreatment with an α1-adrenoceptor blocker and/or a β1-adrenoceptor blocker. In response to IMO, expression of 46 genes was significantly altered in the heart and that of 49 genes was significantly altered in the aorta. Pathway analysis with DAVID Bioinformatics Resources indicated that regulation of transcription and response to endogenous stimulation were the top two scoring pathways. Altered expression of cardiac genes was blunted by pretreatment with a β1-adrenoceptor blocker or α1 + β1-adrenoceptor blockers. In contrast, that of aortic genes was blunted by pretreatment with an α1-adrenoceptor blocker or α1 + β1-adrenoceptor blockers. Activation of α1-adrenoceptor in the blood vessels or activation of β1-adrenoceptors in the heart were mainly responsible for emotional stress-induced alteration of cardiac and vascular gene profiles.

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