Changes in behavior and muscarinic receptor density after neonatal and adult exposure to bioallethrin

Talts, Ulrika; Fredriksson, Anders; Eriksson, Per

doi:10.1016/s0197-4580(98)00093-1

Cited by 39 publications

(26 citation statements)

References 35 publications

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“…Changes in muscarinic receptor distribution and behavioural changes were also observed in adults after similar perinatal administration of bioallethrin (Eriksson & Nordberg, 1990;Eriksson & Fredriksson, 1991;Ahlbom et al, 1994;Talts et al, 1998).…”

Section: 72mentioning

confidence: 92%

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Siegert¹,

Walker²,

Miller³

2009

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Section: 72mentioning

confidence: 92%

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Siegert¹,

Walker²,

Miller³

2009

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“…Those studies also showed that these disturbances are induced at dosages that apparently have no permanent effect when administered to the adult animal. Exposure during this phase of development has also been shown to lead to an increased susceptibility to toxic agents at adult age, indicating that neonatal exposure to toxic agents can potentiate and/or modify the reaction to adult exposure to xenobiotics (Johansson et al, 1995;Talts et al, 1998;Eriksson and Talts, 1999).…”

Section: Vulnerable Periods During Brain Developmentmentioning

confidence: 99%

The developing cholinergic system as target for environmental toxicants, nicotine and polychlorinated biphenyls (PCBs): Implications for neurotoxicological processes in mice

et al. 2001

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During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is associated with numerous biochemical changes that transform the feto-neonatal brain into that of the mature adult. In rodents, the cholinergic transmitter system undergoes a rapid development during the neonatal period, a time when spontaneous motor behaviour also reaches peak activity. We have observed that low-dose exposure to environmental toxicants such as nicotine, polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDE, flame retardants) during the "BGS" can lead to irreversible changes in adult brain function in the mouse. The induction of persistent effects on behaviour and cholinergic nicotinic receptors in the adult animal appears to be limited to a short period during neonatal development. Furthermore, the neurotoxic effects were shown to develop over time, indicating a time-response/time-dependent effect. This indicates that environmental toxicants, such as nicotine, PCBs and probably PBDEs, might be involved in the slow, implacable induction of neurodegenerative disorders and/or interfere with normal aging processes.

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“…Also, previous studies on pyrethroids and organochlorines have shown to cause developmental neurotoxicity in mice, manifested as deranged spontaneous behavior and changes in muscarinic acetylcholine receptor density in the brain, when neonatally exposed (Ahlbom et al, 1994;Eriksson et al, 1992Eriksson et al, , 1993Talts et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Developmental neurotoxic effects of two pesticides: Behavior and neuroprotein studies on endosulfan and cypermethrin

et al. 2015

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Changes in behavior and muscarinic receptor density after neonatal and adult exposure to bioallethrin

Cited by 39 publications

References 35 publications

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

The developing cholinergic system as target for environmental toxicants, nicotine and polychlorinated biphenyls (PCBs): Implications for neurotoxicological processes in mice

Developmental neurotoxic effects of two pesticides: Behavior and neuroprotein studies on endosulfan and cypermethrin

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