2019
DOI: 10.1248/bpbreports.2.2_29
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Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

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Cited by 2 publications
(4 citation statements)
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References 24 publications
(36 reference statements)
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“…Notably, an expanded bile acid pool size, increased liver/body weight ratio, and enlarged gall bladder were observed in chimeric mice, which were also true in the chimeric uPA/SCID mice (Birkenfeld & Shulman, 2014). Fujino et al (2019) also demonstrated a RI‐dependent increase of bile acid content in plasma. The dramatic expansion of bile acid pool in chimeric mice was believed to be partially caused by miscommunication between FGF15 (analog of FGF19 in human) secreted by mouse intestine and FGFR4 on human hepatocytes, which caused a failed inhibition of CYP7A1 expression, the rate‐limiting enzyme in the classical bile acid synthesis pathway, in human hepatocytes of the chimeric liver (Chow et al, 2017; Ellis et al, 2013).…”
Section: Basis For the Application Of Lhm In Metabolic Disordersmentioning
confidence: 92%
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“…Notably, an expanded bile acid pool size, increased liver/body weight ratio, and enlarged gall bladder were observed in chimeric mice, which were also true in the chimeric uPA/SCID mice (Birkenfeld & Shulman, 2014). Fujino et al (2019) also demonstrated a RI‐dependent increase of bile acid content in plasma. The dramatic expansion of bile acid pool in chimeric mice was believed to be partially caused by miscommunication between FGF15 (analog of FGF19 in human) secreted by mouse intestine and FGFR4 on human hepatocytes, which caused a failed inhibition of CYP7A1 expression, the rate‐limiting enzyme in the classical bile acid synthesis pathway, in human hepatocytes of the chimeric liver (Chow et al, 2017; Ellis et al, 2013).…”
Section: Basis For the Application Of Lhm In Metabolic Disordersmentioning
confidence: 92%
“…Tateno et al, 2013). Analysis of bile acid from the bile duct or gall bladder in LHM revealed the presence of human bile acids in the FRG (Ellis et al, 2013), FRGN (Chow et al, 2017), and uPA/SCID (Fujino et al, 2019) systems suggesting a functional bile acid system in LHM.…”
Section: Bile Duct Systemmentioning
confidence: 97%
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