Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis

Sharif, Mohammed; Salisbury, Chris; Taylor, David J.; Kirwan, John R.

doi:10.1002/1529-0131(199807)41:7<1203::aid-art9>3.0.co;2-2

Cited by 50 publications

(24 citation statements)

References 27 publications

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“…19,20 A possible correlation between steroid therapy and MMP-3 levels was examined in patients in the present study. All patients with active disease and 4 of 14 patients in remission received corticosteroids.…”

Section: Discussionmentioning

confidence: 95%

Matrix Metalloproteinases as Novel Disease Markers in Takayasu Arteritis

et al. 2003

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Background-Takayasu arteritis (TA) is a chronic vasculitis that primarily affects large elastic arteries. Monitoring of disease activity is crucial because the disease tends to progress despite treatment with glucocorticoid and/or immunosuppressive agents. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have generally been used as disease activity markers, but these are nonspecific inflammatory markers and lack the sensitivity and specificity to accurately monitor the disease status. Given the histological findings characterized by destruction of elastic fibers, we hypothesized that matrix metalloproteinases (MMPs) could be useful as markers of disease activity in TA. Methods and Results-A consecutive series of 25 patients with TA were enrolled in this study. According to the National Institutes of Health criteria of disease activity, 11 were in an active phase and the remaining 14 were in remission. Circulating levels of MMP-2, MMP-3, and MMP-9 were determined by ELISA in all patients with TA and controls. MMP-2 levels were higher in patients with TA than in controls, but no correlation was found between serum MMP-2 and disease activity score. In contrast, MMP-3 and MMP-9 levels in patients with active disease were higher than in patients in remission and controls, and a positive correlation was demonstrated between circulating levels of MMP-3 or MMP-9 and disease activity score. The high levels of MMP-3 and MMP-9 improved when patients underwent remission. Conclusions-The present results indicate that MMP-2 can be helpful in diagnosing TA and that MMP-3 and MMP-9 can be used as activity markers for TA.

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Section: Discussionmentioning

confidence: 95%

Matrix Metalloproteinases as Novel Disease Markers in Takayasu Arteritis

et al. 2003

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“…21 Sharif et al observed a doubling of serum MMP-3 levels in patients with rheumatoid arthritis (RA) who were administered 7.5 mg of prednisolone daily, whereas the clinical and biological parameters of RA disease activity decreased with the treatment. 22 Measuring MMP-3 to assess TA disease activity should be done with caution. Among these new biomarkers, PTX3 was the most reliable single marker for several reasons.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Assessment of Takayasu Arteritis by Multiple Biomarkers

Ishihara

Haraguchi

Tezuka

et al. 2013

Circ J

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“…However, the administration of PSL for three months increases serum MMP-3 levels in the cases of lupus nephritis (9). In RA, low-dose PSL treatment over 2 years may also increase serum pro-MMP-3 (proenzyme form of MMP-3) levels although synovium-derived markers such as hyaluronate decrease suggesting the remission of the articular synovitis (11). According to these findings, the serum pro-MMP-3 level may be increased by changes of joint tissue metabolism due to PSL therapy despite the fact the therapy ameliorates the synovitis (11).…”

Section: Discussionmentioning

confidence: 99%