Changes in biologic characteristics of breast cancer treated with high-intensity focused ultrasound

Wu, Feng; Wang, Zhibiao; Cao, Youde; Chen, Wenzhi; Zhang, Jianzhong; Bai, Jing; Zhu, Hui; Li, Kequan; Chen, Jin; Xie, Fang-Lin; Su, Hai-Bing; Gao, Gen-Wu

doi:10.1016/s0301-5629(03)01034-2

Cited by 47 publications

(52 citation statements)

References 21 publications

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“…The results indicated HIFU could induce wide local ablation for breast cancer, including tumor and 1.5-2.2 cm normal breast tissue surrounding the tumor in all patients. No expression of proliferating cell nuclear antigen, matrix metalloproteinase-9, cell surface glycoprotein CD44v6 and erbB2 mRNA were detected, and a dramatic decrease in telomerase activity was measured within the treated tumor cells in the HIFU group, indicating that the treated tumor cells lost the abilities of proliferation, invasion, immortalization, and metastasis (46). The authors' conclusion is that HIFU is effective, safe, and feasible in the treatment of localized breast cancer.…”

Section: Breast Cancermentioning

confidence: 92%

Extracorporeal high intensity focused ultrasound in the treatment of patients with solid malignancy

2006

Minimally Invasive Therapy & Allied Technologies

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The ideal treatment of localized cancer should cause the complete death of tumor cells without damage to surrounding normal tissue. High intensity focused ultrasound (HIFU) is such a potential treatment, which can induce complete coagulation necrosis of a targeted tumor, at depth, through the intact skin. The concept of using HIFU as a non-invasive therapy has attracted attention in medicine for 60 years. Recently, it has received increasing interest as a promising modality for the treatment of localized solid malignancies. The goal of this article is to introduce recent clinical developments in the use of extracorporeal HIFU ablation for solid tumors, including those of liver, breast, bone, kidney, pancreas, soft tissue, and uterus. It describes the physical principles and ablative mechanisms, three-dimensional therapeutic regimes, and medical imaging used in HIFU. Currently, large numbers of patients with solid malignancy are already treated using HIFU, and short-term clinical results are very encouraging. However, large-scale randomized clinical trials are necessary to evaluate long-term efficacy of HIFU treatment for solid malignancies. It is concluded that this non-invasive ablation can be considered as a conventional therapy for widespread clinical use only when the results from prospective, randomized clinical trials worldwide are available.

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Section: Breast Cancermentioning

confidence: 92%

Extracorporeal high intensity focused ultrasound in the treatment of patients with solid malignancy

2006

Minimally Invasive Therapy & Allied Technologies

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“…We also noted that the expression of cell nuclear antigen (PCNA), CD44v6, and metalloproteinase (MMP)-9 was significantly higher in the untreated cancerous tissue than that in the untreated normal breast tissue, while there was no expression in the HIFUtreated area. Additional histological analysis using NADH staining [28] confirmed complete necrosis.…”

Section: Hifu Ablation For Breast Cancermentioning

confidence: 86%

High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

Zhang

Wang

2010

Front. Med. China

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High-intensity focused ultrasound (HIFU) is a technique to destroy tissue at depth within the body, selectively and without harming overlying and adjacent structures within the path of the beam because the ultrasonic intensity at the beam focus is much higher than that outside of the focus. Diagnostic ultrasound is the first imaging modality used for guiding HIFU ablation. In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups' reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors. HIFU is a promising technique. Most importantly, HIFU offers patients another alternative when those patients have no other treatment available.

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“…Pathologic findings revealed that HIFU-treated tumor cells underwent complete coagulative necrosis, and tumor vascular vessels were severely damaged. Immunohistochemical staining showed that HIFU-treated tumor cells lost the abilities to proliferate, invade and metastasize [4]. However, it is essential to evaluate the long-term clinical results of HIFU treatment for patients with breast cancer.…”

Section: Introductionmentioning

confidence: 98%

Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer

Wang

Zhu

et al. 2005

Breast Cancer Res Treat

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Changes in biologic characteristics of breast cancer treated with high-intensity focused ultrasound

Cited by 47 publications

References 21 publications

Extracorporeal high intensity focused ultrasound in the treatment of patients with solid malignancy

Extracorporeal high intensity focused ultrasound in the treatment of patients with solid malignancy

High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

Extracorporeal high intensity focused ultrasound treatment for patients with breast cancer

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