Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID‐19): a meta‐analysis

Xiong, Ming; Li, Xue; Wei, You-Dong

doi:10.1111/bjh.16725

Cited by 167 publications

(180 citation statements)

References 8 publications

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“…Some previous articles focused on the association of COVID-19 severity with changes in primary and secondary hemostatic parameters, reporting that severe patients show longer prothrombin time (PT) and higher D-dimer values, with a lower platelet count. 5,11,12,[43][44][45] Similar results were found in nonsurvivors to COVID-19 as compared with survivors. Among 183 hospitalized patients with COVID-19, it has been documented that 71.4% of nonsurvivors have overt disseminated intravascular coagulation (DIC) as compared with only 0.6% of survivors.…”

Section: Discussionsupporting

confidence: 75%

COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies

Minno

Ambrosino

Calcaterra

et al. 2020

Semin Thromb Hemost

251

209

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Coronavirus disease 2019 (COVID-19) may have a wide spectrum of clinical presentations, leading in some cases to a critical condition with poor long-term outcomes and residual disability requiring post-acute rehabilitation. A major concern in severe COVID-19 is represented by a concomitant prothrombotic state. However, contrasting data are available about the prevalence of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and/or pulmonary embolism (PE). A detailed search on the association of COVID-19 with thromboembolic complications was conducted in the main electronic databases (PubMed, Web of Science, and Scopus) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The weighted mean prevalence (WMP) with 95% confidence interval (95% CI) was calculated with the random-effects model. Twenty studies enrolling 1,988 COVID-19 patients were included. The WMP of VTE was 31.3% (95% CI: 24.3–39.2%). The WMP of DVT was 19.8% (95% CI: 10.5–34.0%), whereas the WMP of PE was 18.9% (95% CI: 14.4–24.3%). Similar results were obtained when specifically analyzing studies on patients admitted to intensive care units and those on patients under antithrombotic prophylaxis. Regression models showed that an increasing age was associated with a higher prevalence of VTE (Z-score: 3.11, p = 0.001), DVT (Z-score: 2.33, p = 0.002), and PE (Z-score: 3.03, p = 0.002), while an increasing body mass index was associated with an increasing prevalence of PE (Z-score = 2.01, p = 0.04). Male sex did not impact the evaluated outcomes. The rate of thromboembolic complications in COVID-19 patients is definitely high. Considering the risk of fatal and disabling complications, adequate screening procedures and antithrombotic strategies should be implemented.

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Section: Discussionsupporting

confidence: 75%

COVID-19 and Venous Thromboembolism: A Meta-analysis of Literature Studies

Minno

Ambrosino

Calcaterra

et al. 2020

Semin Thromb Hemost

251

209

View full text Add to dashboard Cite

show abstract

“…Most often, fibrinogen and D‐dimer are elevated and correlated with acute inflammatory markers such as C‐reactive protein. Prothrombin time prolongation is often seen 3,6 . Unlike typical DIC, patients often exhibit a platelet count that is only mildly decreased, a partial thromboplastin time that is normal‐to‐mildly prolonged, and no signs of microangiopathy.…”

Section: Clinical Parameter Pediatric Recommendations Other Consideramentioning

confidence: 99%

COVID‐19 anticoagulation recommendations in children

Loi

Branchford

Kim

et al. 2020

Pediatric Blood & Cancer

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“…The effects of COVID‐19 were initially thought to be limited to the lungs, but the severity of illness and the emerging appreciation that patients were in a hypercoagulable state led us to question this conclusion 10 …”

Section: Coagulation Systemmentioning

confidence: 99%