Changes in Blood Coagulation Profiles of Dairy Cows During Pregnancy and in Heifer Calves After Hormone Treatment

Gentry, Patricia A.; Liptrap, R.M.; Black, W. D.

doi:10.4141/cjas79-063

Cited by 20 publications

(26 citation statements)

References 18 publications

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“…High levels in D-dimer in sick animals most probably resulted from the activation of intravascular fibrinolysis. Other coagulation parameters obtained from healthy cattle such as fibrinogen (216.50 ± 10.55 mg/dl); TT (24.80 ± 1.77 sec); PT (27.53 ± 1.55 sec) and aPTT (27.43 ± 3.35 g/dL) were concomitant with the results of earlier studies (Gentry et al 1979, Sobiech et al 2013, Karakurum et al 2009). Although different analysers have been used in the above studies, these results were very close to each other and reinforced the accuracy of the data obtained from the present study.…”

Section: Discussionsupporting

confidence: 73%

The diagnostic importance of coagulation parameters in cattle having natural theileriosis

Güneş

Onmaz

Keleş

et al. 2017

Polish Journal of Veterinary Sciences

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The purpose of this study was to determine the diagnostic importance of coagulation parameters in cattle with natural theileriosis. Nine Holstein cross-breed cattle with theileriosis as infected group and 6 healthy Holstein cattle as control group were used in the present study. Mean fibrinogen level, thrombin time (TT), activated partial thromboplastin time (aPTT) and prothrombin time (PT) were not statistically different when control and infected groups compared, except for the D-dimer concentration. Quantitative D-dimer concentrations were determined by immune-turbidimetric assay. D-dimer values increased significantly (p<0.05) in infected group (631.55 ± 74.41 μg/L) compared to control group (370.00 ± 59.94 μg/L). D-dimer sensitivity and specificity were also determined at cut-off concentrations (372 μg/L). Sensitivity and specificity of D-dimer values were determined to be 88.89% and 83.33%, respectively. D-dimer is thought to be important indicator in the evaluation of the prognosis in theileriosis cases. Analysis of D-dimer values before and after treatment in controlled case studies were suggested in future studies to enlighten the issue.

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Section: Discussionsupporting

confidence: 73%

The diagnostic importance of coagulation parameters in cattle having natural theileriosis

Güneş

Onmaz

Keleş

et al. 2017

Polish Journal of Veterinary Sciences

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“…Similarly, no statistically significant alteration in platelet numbers was observed in cows during the 6 wk before and after parturition (Gentry et al 1979).…”

mentioning

confidence: 79%

Interrelationships Between Blood Coagulation Factors and Plasma Hormone Levels in the Periparturient Sow

Liptrap¹,

Gentry²

1984

Can. J. Anim. Sci.

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“…During human pregnancy, factor XI activity shows a consistent decline (Hellgren and gestation period (Stirling et al 1984;Pekonen et al 1986), in the dog the platelet count increases to reach a peak around the rition (Doxey 1966), while in the cow the platelet count shows a slight but consistent decline during the second trimester and returns to nonpregnant values by the end of the gestation period (Gentry et d. 1979). …”

Section: Canine and Bovine Speciesmentioning

confidence: 92%

“…Compared with either the woman or the dog, the most obvious feature of the coagulation profile in the cow during pregnancy is the lack of significant alterations (Gentry et al 1979). Throughout pregnancy and during parturition no changes were observed for the A or the one-stage prothrombin time assays and no statisticalpHZy significant alterations ( p > 0.05)…”

Section: Canine and Bovine Speciesmentioning

confidence: 98%

Comparative hemostatic protein alterations accompanying pregnancy and parturition

Gentry¹,

Liptrap²

1988

Can. J. Physiol. Pharmacol.

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G 2 WIReceived F e b m q 25, I987 GENTRY, P. A., and LIPTRAP, R. M. 1988. Comparative hemostatic protein alterations accompanying pregnancy md parturition.Cm. J. PRysiol. Phmacol. 66: 67 1-678. Pregnancy and parturition represent adaptive, physiological stress situations that elicit both blood coagulation protein changes and endocrine alterations. This paper briefly reviews the interreIationship of these responses by comparing the available data in several mammalian species including man, dog, cow, and pig. Hemostasis is an enzymatically controlled cascade process involving platelets and specific coagulation proteins that results in the formation of insoluble strands sf fibrin. Although qualitatively similar in most m als, quantitative differences exist in the circulating levels of individual coagulation proteins which may con&ibua towards the different rates of clot formation. In the late gestation stage of human pregnancy, significant increases are observed in the circulating biological activities of the coagulation factors VII, VIII:C, IX, and X. In the dog, the activities of factors VII and IX reach peak values in midpregnancy, while in the cow little or no changes are observed except for factor VII values which show a significant increase only around the time of parturition. These coagulation changes appear to be associated with fluctuations in circulating hormone values, particularly plasma estrogen. In human pregnancy, the circulating levels of fibrinogen, the precursor of fibrin, increase during the gestation period reaching maximum values during and ediately following parturition. In the dog and the cow two distinct increases in fibrinogen values are observed, the first in the midgestation period a d the second in the immediate postparturition period. In the pig, fibrinogen values also rise significantly at parturition. Oral contraceptive studies in the human female have indicated that changes in circulating activities of coagulation proteins are hornonally influenced. Results from injection of various steroid homones in the dog, pig, and rabbit have shown this to also hold true for these species. In both the dog and the pig, progesterone and the prostaglandin, WF2,, induce marked increases in fibrinogen values, while estrogen done has apparently no effect on this protein. These results emphasize the lack of a clear understanding of the relationship between the coagulation proteins and reproductive h o m n e changes. In all species examined, fibrinogen values rise at parturition when progesterone values are falling. Although in the human female the effect of pregnancy and ingestion of ord contraceptives on fibrinolysis has been examined, this aspect of the hemostatic process has not k e n evaluated in domestic animals. The paucity of information and the diversity of the response of the coagulation proteins in different species to homond manipulation reflect the limited understanding that exists pertaining to the interrelationships between circulating hormones, coagulation proteins, and hemostasis. GENTRY...

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Changes in Blood Coagulation Profiles of Dairy Cows During Pregnancy and in Heifer Calves After Hormone Treatment

Abstract: GeNrnv, P. A., Lrsrnrp, R. M. rNo Br-acr

Cited by 20 publications

References 18 publications

The diagnostic importance of coagulation parameters in cattle having natural theileriosis

The diagnostic importance of coagulation parameters in cattle having natural theileriosis

Interrelationships Between Blood Coagulation Factors and Plasma Hormone Levels in the Periparturient Sow

Comparative hemostatic protein alterations accompanying pregnancy and parturition

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