Changes in blood content of prostaglandin F2α and leukotrienes C4 and B4 in rats after intravenous injection of contrast agents

Abstract

It is shown that Triombrast=Hexabrix=Omnipaque_<Melitrast<Ultravist in a dose-independent manner increase the level of prostaglandin F2~ and leukotrienes C 4 and B 4 in the blood of sensitive rats (50%) 15 min after intravenous injection of the preparation, the changes in prostaglandin F2~ being maximal, while those in leukotrienes C 4 minimal. The effect of nonionic contrast agents on the blood level of prostaglandin F:~ (0.1-2.0 g I/kg, except for Omnipaque) and leukotriene B 4 (in a dose of 0.5 g I/kg) is more pronounced in comparison with the ionic preparations.