Changes in blood-flow impedance of the human corpus luteum throughout the luteal phase and during early pregnancy

Tamura, Hiroshi; Takasaki, Akihisa; Taniguchi, Koichi; Matsuoka, Aki; Shimamura, Katsunori; Sugino, Norihiro

doi:10.1016/j.fertnstert.2007.10.056

Cited by 50 publications

(52 citation statements)

References 39 publications

(57 reference statements)

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“…blood flow is closely associated with luteal function (32) and that vitamin E or l-arginine treatment improves corpus luteum blood flow in our unpublished data. However, in the present study, vitamin E, l-arginine, or sildenafil citrate caused no significant effects on the numbers of preovulatory follicles or serum E 2 concentrations in the natural cycles, clomiphene cycles, hMG-hCG cycles, and IVF-ET cycles.…”

Section: Discussionsupporting

confidence: 56%

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium

Takasaki

Tamura

Miwa

et al. 2010

Fertility and Sterility

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147

112

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Section: Discussionsupporting

confidence: 56%

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium

Takasaki

Tamura

Miwa

et al. 2010

Fertility and Sterility

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147

112

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“…The down-regulation of ER and PR in the endometrial membrane and the expression of integrin ανβ3 play important roles in the implantation [25] . Our research revealed that, in the mid-luteal phase of LUF, the lower level of progesterone and the decreased expression of integrin ανβ3 may contribute to the failure of down-regulation and negatively affect the secretion, decidualization and degradation of endometrium.…”

Section: Discussionmentioning

confidence: 99%

Impact of luteinized unruptured follicles on endometrial receptivity

Yang

Jiang

et al. 2011

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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This study examined the impact of luteinized unruptured follicle (LUF) on endometrial receptivity. The menstrual cycle of 17 LUF patients (LUF group) and 13 ovulatory women (control group) was monitored by measuring LH level in urine and by ultrasonic examination. An endometrial biopsy at the sixth to tenth day after LH surge was taken in all the patients. The expressions of endometrial ER, PR and integrin ανβ3 were immunohistochemically determined. At the same time, the serum levels of E(2) and P were detected by chemiluminescence. The results exhibited that (1) The mean serum P level in LUF group (7.32±2.56 ng/mL) was significantly lower than that in control group (11.17±3.17 ng/mL) (P<0.01). But there was no significant difference in the mean serum E2 levels between LUF group (179.35±81.60 pg/mL) and the control group (198.58±75.23 pg/mL) (P>0.05); (2) The mean expression intensities of ER, PR in endometrium of LUF group (183.86±2.43, 167.94±3.04) were significantly higher than those in control group (109.35±6.31, 105.98±4.07) (P<0.01); (3) The mean expression intensities of integrin ανβ3 in endomtrium of LUF patients (114.90±11.38) were significantly lower than those in control group (191.34±1.82) (P<0.01); (4) The change profile of integrin ανβ3 expression in the endometrium of LUF patients was in positive relation with serum P level (r=0.77, P<0.01), but bore no significant relationship with serum E(2) level (r=0.01, P>0.05). It was concluded that the depression of serum P levels in LUF patients was closely related to the failure of the down-regulation of ER and PR, and the low expressions of integrin ανβ3 also suggested that the delayed implantation and the impaired endometrial receptivity had impact on embryonic implantation.

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“…This requires stabilization of blood vessels in addition to high vascularization in the CL because mature blood vessels are critical for maintaining blood flow [6][7][8]. Blood vessel stabilization is regulated by pericytes, which support the interaction between endothelial cells [9].…”

Section: Introductionmentioning

confidence: 99%

Involvement of Bone Marrow-Derived Vascular Progenitor Cells in Neovascularization During Formation of the Corpus Luteum in Mice1

Kizuka¹,

Tokuda²,

Takagi³

et al. 2012

Biology of Reproduction

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Neovascularization is necessary for formation of the corpus luteum (CL) and includes angiogenesis and vasculogenesis. Vasculogenesis is the formation of new blood vessels by bone marrow-derived endothelial progenitor cells. Here we investigated whether vasculogenesis occurs in neovascularization during CL formation. Mice transplanted with bone marrow from transgenic mice expressing green fluorescent protein (GFP) were injected with equine chorionic gonadotropin and human chorionic gonadotropin (hCG) to induce ovulation and subsequent CL formation. Immunohistochemistry was performed on the ovaries obtained before hCG injection and at 6, 12, and 24 h after hCG injection using antibodies for CD34 or CD31 (an endothelial cell marker), platelet-derived growth factor receptor beta (PDGFR-beta, a pericyte marker), F4/80 (a macrophage marker), and GFP (a bone marrow-derived cell marker). Cells immunostained for CD34, PDGFR-beta, F4/80, and GFP were present in the theca cell layer of the preovulatory follicle before hCG injection. Each of these cell types invaded the granulosa cell layer after hCG injection, and a number of them were observed in the CL 24 h after hCG injection. Fluorescence-based immunohistochemistry or double immunohistochemical staining revealed that a few CD34/CD31-positive cells and PDGFR-beta-positive cells were also positive for GFP in the preovulatory follicle and CL, and that many of the GFP-positive cells recruited to the CL during CL formation were F4/80-positive macrophages. In conclusion, bone marrow-derived vascular progenitor cells and macrophages contribute to neovascularization during CL formation.

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Changes in blood-flow impedance of the human corpus luteum throughout the luteal phase and during early pregnancy

Cited by 50 publications

References 39 publications

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium

Impact of luteinized unruptured follicles on endometrial receptivity

Involvement of Bone Marrow-Derived Vascular Progenitor Cells in Neovascularization During Formation of the Corpus Luteum in Mice1

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