Changes in blood lymphocyte populations after multiple trauma

Menges, T.; Engel, J.; Welters, Ingeborg; Wagner, Ralf-Michael; Little, Simon; Ruwoldt, Ralph; Wollbrueck, Matthias; Hempelmann, G.

doi:10.1097/00003246-199904000-00026

Cited by 204 publications

(155 citation statements)

References 22 publications

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“…Besides the functional defects that have been previously described, a marked decrease in the number of circulating lymphocytes has been observed in patients after sepsis and severe trauma (Table 1) (17,20,(120)(121)(122). Most importantly, the extent of this lymphopenia has been correlated with the development of nosocomial infections in those patients (20,122).…”

Section: Studies Of T-lymphocyte Subsetsmentioning

confidence: 63%

Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony

Monneret

Venet

Pachot

et al. 2008

Mol Med

306

323

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Section: Studies Of T-lymphocyte Subsetsmentioning

confidence: 63%

Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony

Monneret

Venet

Pachot

et al. 2008

Mol Med

306

323

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“…For many types of cancer, lymphocytopenia indicates a generalized state of immunodepression (Wenger et al, 1999), and survival appears to be adversely influenced by depressed immune function. The number of CD4+ helper lymphocytes may decrease, and CD8+ suppressor lymphocytes may increase due to disturbed inflammatory response, and immunosuppression may result (Menges et al, 1999). The increase in the numbers of neutrophils and / or decreased numbers of lymphocytes may suppress lymphokine-activated killer cells.…”

Section: Discussionmentioning

confidence: 99%

Elevated Neutrophil-to-Lymphocyte Ratio in Squamous Cell Carcinoma of Larynx Compared to Benign and Precancerous Laryngeal Lesions

Kum¹,

Özcan²,

Baklacı³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Laryngeal carcinogenesis is a multifactorial process that has not been fully elucidated. Despite extensive research, reliable markers with diagnostic and prognostic value are still lacking. It was recently reported that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) may correlate with an increased risk of recurrence, tumor aggressiveness and poorer prognosis in various malignancies. The aim of this study was to examine whether NLR could be used as an inflammatory marker to differentiate laryngeal squamous cell carcinoma (LSCC) patients from benign laryngeal lesion (BLL) and precancerous laryngeal lesion (PLL) patients. Materials and Methods: This retrospective study was performed on 209 patients admitted to a tertiary referral center with laryngeal lesions and undergoing biopsies to establish their histopathological diagnosis. We reviewed the patient files for their clinical, histopathological and laboratory data. The patients were divided into three groups according to their histopathological findings, as BLL, PLL and LSCC groups. The patients in the PLL group were also divided into three subgroups as mild, moderate and severe dysplasia/ carcinoma in situ (CIS) subgroups. The groups were compared for NLR and the other laboratory data. Results: The mean NLRs of the BLL, PLL and the LSCC groups were 2.12±0.86, 2.32±0.68 and 3.46±1.51, respectively, and the difference was statistically significant (p=0.001). The mean NLRs of the patients with PLL and LSCC were significantly higher than the patients with BLL (p=0.031 and p=0.001, respectively). The mean NLRs were similar among mild dysplasia, moderate dysplasia and severe dysplasia / CIS groups (p>0.05). Conclusions: To our knowledge, this is the first study investigating NLR in BLL, PLL and LSCC. NLR is an inexpensive, reproducible and widely available blood test, and could be a useful inflammatory marker to differentiate LSCC from BLL and PLL.

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“…On the other hand, human immune response triggered by colorectal cancer mainly relays on lymphocytes, whereas systematic inflammation significantly depressed cellular immunity, resulting in a significantly decrease of CD4/T lymphocytes and an increasing of CD8/suppressor T lymphocytes [38,39]. Thus, cancer-triggered inflammation resulted in elevated NLR.…”

Section: Discussionmentioning

confidence: 99%

The Pre-treatment Systemic Inflammatory Response Biomarkers are Important Determinant of Prognosis for Patients Undergoing Neoadjuvant Therapy for Rectal Cancer

Zaghlou¹,

Abbas²

2017

J Cancer Sci Ther

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Changes in blood lymphocyte populations after multiple trauma

Cited by 204 publications

References 22 publications

Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony

Monitoring Immune Dysfunctions in the Septic Patient: A New Skin for the Old Ceremony

Elevated Neutrophil-to-Lymphocyte Ratio in Squamous Cell Carcinoma of Larynx Compared to Benign and Precancerous Laryngeal Lesions

The Pre-treatment Systemic Inflammatory Response Biomarkers are Important Determinant of Prognosis for Patients Undergoing Neoadjuvant Therapy for Rectal Cancer

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