Changes in blood parameters in pregnant Japanese White rabbits

Abstract

-Changes in blood parameters, especially those related to blood coagulations, were examined on gestational days (GDs) 6, 18 and 28 in Japanese White rabbits. As compared with the non-pregnant group, the following changes were observed in the pregnant group. For blood coagulation-related parameters, fibrinogen, platelets and antithrombin time III (ATIII) was significantly increased on GD 18 and/or GD 28, and activated partial thromboplastin time (APTT) was significantly prolonged on GDs 18 and 28. For the other hematological and blood chemical parameters, hemoglobin and hematocrit values were significantly decreased on GDs 18 and 28. Reticulocyte counts significantly and prominently increased on GD 18 and then decreased to significantly lower levels than those in the non-pregnant group on GD 28. Eosinophils and basophil showed significant decreases on GD 18 and/or GD 28. The serum progesterone concentration reached its highest level on GD 18. Total protein (TP), albumin, alkaline phosphatase (ALP), alanine aminotransferase (ALT), cholesterol, calcium, glucose and blood urea nitrogen were significantly decreased on GD 18 and/or GD 28. These results were almost similar to those in the pregnant New Zealand White rabbits (Mizoguchi et al., 2010).

Quantitative Expression and Immunohistochemical Detection of Glucose Transporters, GLUT1 and GLUT3 in the Rabbit Placenta during Successful Pregnancy

“…In present study, the maternal blood glucose was significantly decreased during gestation in comparison with that of the non-pregnant blood serum, which is almost in accordance with those most recently reported in pregnant New Zealand white and Japanese white rabbits [22,29]. Change of maternal glucose concentration during gestation may reflect glucose supply or replenishment according to nutritional demand for the rabbit development [43].…”

Serum biochemistry in hystricomorpha: agouti (Dasyprocta prymnolopha) during pregnancy

“…Due to this condition in the captive production of this animal of that study there was food supplementation during this period, which may be related to this serum glucose increase in this phase. In rabbits the glucose serum levels fall near to parturition in the final third of pregnancy due to rapid fetal growth in the last weeks of pregnancy, and may even be related to the lactation peak, with the uptake of this metabolite by the mammary gland for lactose synthesis (HANEDA et al, 2010;MIZOGUCHI et al, 2010). The initial hypoglycemia in pregnant sheep is described as pregnancy toxemia (SANTOS et al, 2011) and this fact corroborates our study since during pregnancy in agoutis (Figure 2) no pathological changes were observed.…”

Models of Intrauterine growth restriction and fetal programming in rabbits

“…Litter size can range between 4 and 12 kits, depending on the breeding program and genetic background (Foote & Carney, 2000;López-Tello et al, 2015;López-Tello, Arias-Álvarez, Jiménez-Martínez, Barbero-Fernández et al, 2017). Due to their size, serial blood collections of the rabbit doe can be performed to inform of the endocrine and metabolic changes during pregnancy (Haneda et al, 2010;López-Tello, Arias-Álvarez, Jiménez-Martínez, Barbero-Fernández et al, 2017). Moreover, ultrasound imaging of the developing conceptus can be undertaken to assess longitudinal changes with subsequent follow up of the offspring (Chavatte-Palmer et al, 2008;López-Tello et al, 2015;López-Tello, Arias-Álvarez, Jiménez-Martínez, Barbero-Fernández et al, 2017;Osmanski et al, 2015;Polisca, Scotti, Orlandi, Brecchia, & Boiti, 2010).…”