Changes in body mass index in long-term survivors of childhood acute lymphoblastic leukemia treated without cranial radiation and with reduced glucocorticoid therapy

Touyz, Lauren M.; Cohen, Jennifer; Neville, Kristen A; Wakefield, Claire E.; Garnett, Sarah P.; Mallitt, Kylie‐Ann; Grech, Allison; Cohn, Richard J.

doi:10.1002/pbc.26344

Cited by 33 publications

(31 citation statements)

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“…Evaluating the Height per Age Index most of the patients had an adequate height for their age similar to the data found in another study [17]. However, studies have observed a significant reduction in the Z-scores of Height per Age Index overtime in children with ALL [6]. Our study found a statistically significant difference in relation to height for age between M1 and M3 (p=0.016); and between M2 and M3 (p=0.006), demonstrating a possible deficit in growth over treatment.…”

Section: Discussionsupporting

confidence: 80%

“…A few studies concluded that male individuals have a greater propensity to gain weight compared to female individuals during the treatment, and this is in line with the differences identified among genders in the pediatric population [23]. A retrospective study that evaluated children with ALL, analyzing the Z-scores of BMI, height and weight per gender, found that male individuals had a significantly larger BMI, while females showed a greater increase in the Z-score of BMI over seven years of follow up compared to their BMI at the time of diagnosis [6]. Other studies indicate that women are at greater risk for obesity or for persisting in a nutritional state of obesity for a longer period after chemotherapy, and it is essential to prevent weight gain and complications over the long term as a result of obesity [9], similarly to what happened with the population studied, that presented a significant difference in the BMI/A index in the female gender over time.…”

Section: Discussionsupporting

confidence: 66%

“…Advances in antineoplastic treatments and in the care of children with cancer resulted in a significant increase in cancer cure rates [4]. This longer survival is accompanied by an increase in the chances of development of various late effects, such as premature mortality, osteoporosis, growth deficit, coronary artery disease, hypertension, secondary malignant neoplasms, psychosocial effects, metabolic disorders such as overweight, glucose intolerance, insulin resistance, and diabetes, due to chemotherapy and the use of high doses of corticosteroids [5][6][7][8]. Obesity in patients who survive childhood cancer may develop due to the oncological treatment itself, because of the reduction of physical activity, family-related factors, unhealthy nutrition, hormone changes and prolonged exposure to the use of corticosteroids [6,9].…”

Section: Introductionmentioning

confidence: 99%

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Changes in nutritional status in adolescents surviving leukemia and lymphoma

et al. 2020

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Objective To examine the changes in the nutritional status of adolescents aged 10-19 years after a minimum 12 months interval following oncological treatment for leukemias and lymphomas. Methods Longitudinal design quantitative study conducted at Hospital de Clínicas, Porto Alegre. Adolescents aged 10-19 years after a minimum 12 months interval following oncological treatment for leukemias and lymphomas were included. The measures of weight, height, brachial circumference, triceps skinfold thickness, arm muscle circumference and abdominal circumference were collected. Results The sample comprised 50 adolescents who had survived leukemias and lymphomas. In the follow up 38% of the patients were classified as overweight according to the body mass index for their age. There was a significant increase in body mass index for age between the beginning and the end of treatment and follow up (p=0.013) in female individuals, compared to males. The results indicate a reduction in the Z-score means of height for age, with significant differences between the beginning of treatment and follow up (p=0.016); and end of treatment and follow up (p=0.006) in patients of both genders Conclusion The anthropometric indicators show an important frequency of excess weight and increased tricipital skinfold, as well as a significant increase of the body mass index for age and also a growth deficit among the survivors.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Changes in nutritional status in adolescents surviving leukemia and lymphoma

et al. 2020

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“…Las causas del incremento del szIMC pueden ser multifactoriales, y existe posibilidad de que el uso de quimioterapéuticos como los esteroides generen cambios epigenéticos que predispongan a cambios permanentes de la composición corporal 4 . El seguimiento a largo plazo de este grupo de pacientes dará luz a la persistencia o no de la ganancia de peso, y de la composición corporal como una línea de investigación prioritaria 5 . En este sentido, las historias clínicas que revisamos no contaban de forma sistemática con información relacionada con el ambiente nutricional de los pacientes como la existencia de obesidad en los padres, por ejemplo, ni los hábitos de alimentación o ejercicio antes, durante o después del tratamiento.…”

Section: Discussionunclassified

“…Los supervivientes de linfoma en la edad pediátrica pueden tener mayor riesgo de morbimortalidad por causas cardiovasculares, por lo que resulta relevante estudiar los cambios en el IMC que puede presentar esta población después de haber alcanzado la remisión de la enfermedad 5 .…”

Section: Introductionunclassified

Incremento progresivo del índice de masa corporal en supervivientes pediátricos de linfoma

Rangel-Rivera¹,

Méndez-Montoya²,

Anaya-Aguirre³

et al. 2019

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Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer

et al. 2018

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In light of the excellent long-term survival of childhood cancer patients, it is imperative to screen for factors affecting health, function, and quality of life in long-term survivors. OBJECTIVE To comprehensively assess chemotherapy-induced peripheral neuropathy in childhood cancer survivors to define disease burden and functional effect and to inform screening recommendations. DESIGN, SETTING, AND PARTICIPANTS In this cross-sectional observational study, cancer survivors who were treated with chemotherapy for extracranial malignancy before age 17 years were recruited consecutively between April 2015 and December 2016 from a single tertiary hospital-based comprehensive cancer survivorship clinic and compared with healthy age-matched controls. Investigators were blinded to the type of chemotherapy. A total of 169 patients met inclusion criteria, of whom 48 (28.4%) were unable to be contacted or declined participation. EXPOSURES Chemotherapy agents known to be toxic to peripheral nerves. MAIN OUTCOMES AND MEASURES The clinical peripheral neurological assessment using the Total Neuropathy Score was compared between recipients of different neurotoxic chemotherapy agents and control participants and was correlated with neurophysiological, functional, and patient-reported outcome measures. RESULTS Of the 121 childhood cancer survivors included in this study, 65 (53.7%) were male, and the cohort underwent neurotoxicity assessments at a median (range) age of 16 (7-47) years, a median (range) 8.5 (1.5-29) years after treatment completion. Vinca alkaloids and platinum compounds were the main neurotoxic agents. Clinical abnormalities consistent with peripheral neuropathy were common, seen in 53 of 100 participants (53.0%) treated with neurotoxic chemotherapy (mean Total Neuropathy Score increase, 2.1; 95% CI, 1.4-2.9; P < .001), and were associated with lower limb predominant sensory axonal neuropathy (mean amplitude reduction, 5.8 μV; 95% CI, 2.8-8.8; P < .001). Functional deficits were seen in manual dexterity, distal sensation, and balance. Patient-reported outcomes demonstrating reduction in global quality of life and physical functioning were associated with the Total Neuropathy Score. Cisplatin produced long-term neurotoxicity more frequently than vinca alkaloids. CONCLUSIONS AND RELEVANCE Clinical abnormalities attributable to peripheral neuropathy were common in childhood cancer survivors and persisted long term, with concurrent deficits in patient-reported outcomes. Both the type of neurotoxic agent and a targeted clinical neurological assessment are important considerations when screening survivors for long-term neuropathy. Further development of peripheral neuropathy-specific pediatric assessment tools will aid research into neuroprotective and rehabilitative strategies.

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Changes in body mass index in long-term survivors of childhood acute lymphoblastic leukemia treated without cranial radiation and with reduced glucocorticoid therapy

Cited by 33 publications

References 33 publications

Changes in nutritional status in adolescents surviving leukemia and lymphoma

Changes in nutritional status in adolescents surviving leukemia and lymphoma

Incremento progresivo del índice de masa corporal en supervivientes pediátricos de linfoma

Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer

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