Changes in body water distribution during the first two weeks of life.

Maclaurin, J. C.

doi:10.1136/adc.41.217.286

Cited by 72 publications

(25 citation statements)

References 18 publications

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“…The higher average CBS/kg of 424±7.5 ml/kg in our 24 infants of low birth weight was almost identical to that of 8 infants of low birth weight studied within 24 h of birth by CLAPP et al [12] (423 ml/kg). In their study, as well as those by SMULL [53] and MCLAURIN [35], data concerning both study infants and measurements were grouped in such a manner that definitive analysis was difficult, while in two other series [22,23], infants were all studied more than 24 h after birth.…”

Section: Discussionmentioning

confidence: 99%

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Bromide Space Studies in Infants of Low Birth Weight

Cassady

1970

Pediatr Res

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The present study reports measurements of the corrected bromide space (CBS) in 74 neonates delivered vaginally and studied within 24 h of birth. The results in 37 normally grown (NG) infants ranging in birth weight from 960 to 3,540 g with gestational intervals of 27-43 weeks are contrasted with findings in 37 intrauterine growth-retarded infants (IGR) ranging from 1,000 to 2,460 g in birth weight with gestational intervals of 35-44 weeks.Although a direct relation exists between CBS (liters) and a variety of variables of fetal maturity in both NG and IGR infants, the CBS in both groups would appear best related to birth weight. The corrected bromide space of the IGR was virtually identical with that of their weight peers, there being no significant difference in the regression for CBS versus birth weight in the two groups. Log-log plot of this relation yields a correlation coefficient (r) of 0.98, and may be expressed as:log CBS (liters) = 0.92 X log wt (kg) -0.371 Closer inspection of this relation revealed that an unequal distribution, with preponderance of values below the regression line at higher birth weights, was apparent. This 'tail off' suggested a curvilinear relation of CBS with increasing birth weight, and was even more apparent when the CBS data were expressed as percentage of bcdy weight (ml/kg). The mean CBS/kg in NG prematures (424±SE 7.5 ml/kg) was clearly higher (P<0.001) than in mature study infants (376±SE 8.4 ml/kg). Likewise, the average CBS/kg in the mature IGR (419±SE 11.3 ml/kg) was significantly higher (P<0.025) than the mean for the NG infants (376±SE 8.4 ml/kg). Comparison of data from NG and IGR infants revealed that 3 of 10 premature infants and 10 of 27 mature IGR infants have a CBS/kg more than 2 SD above the mean in NG infants; a CBS in excess of 476 ml/kg was observed in 11 study infants, all but 1 of whom were IGR. Speculation

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Section: Discussionmentioning

confidence: 99%

“…Redistribution or excessive loss of fluid from an extracellular location may reconcile these findings. The literature provides conflicting and inadequate data concerning the early adjustments of extracellular fluid in the perinate [8,21,35]. Although unusual loss of ECW would appear unlikely, definitive data on this point are not yet available.…”

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confidence: 93%

Bromide Space Studies in Infants of Low Birth Weight

Cassady

1970

Pediatr Res

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“…Differences in body composition and immaturity of drug elimination pathways are largely responsible for these changes in disposition. In the full term neonate plasma proteins are qualitatively and quantitatively different to the adult (Wallace, 1977), water constitutes a greater proportion of body weight (Friis-Hansen, 1961;Maclaurin, 1966) and both glomerular filtration and liver metabolism are reduced (Aperia et al, 1981;Short et al, 1976). The major consequence of these differences is that drugs are generally eliminated more slowly in the neonate compared to the adult.…”

Section: Introduction Methodsmentioning

confidence: 99%

Atenolol elimination in the neonate.

Rubin¹,

Butters²,

Reynolds³

et al. 1983

Brit J Clinical Pharma

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1 The elimination of the cardioselective ,8-adrenoceptor antagonist atenolol has been studied in 35neonates by measuring drug concentration in cord blood and in blood obtained at 24 h by heel stab. 2 Elimination rate was assessed by calculating the slopes of lines joining these two concentration points. 3 The slopes had a mean of 0.043 h-1(equivalent to a half-life of 16 h) and were normally distributed with 95% of values being in the range 0.02-0.066. 4 There was no relationship between slope and neonatal weight or skinfold thickness, but most babies were at term and the range of these indices was narrow. 5 Babies who developed a bradycardia had cord atenolol concentrations and slopes which did not differ significantly from those in babies without bradycardia. 6 We conclude that atenolol elimination in the neonate is reduced when compared to adults. This prolonged elimination is consistent with the physiological characteristics of this age group and with previous observations on drugs eliminated by renal excretion.

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“…Es conocido que el metabolismo del agua en el recién nacido sufre grandes variaciones durante los primeros días de vida, y que éstos, son mayores en las 12 primeras horas, (8). También se ha descrito cambios en la glicemia, en las primeras 6 horas de vida (9).…”

Section: Introductionunclassified

“…Todo se refleja a través de las variaciones de los valores de glicemia (9,10), hematocrito (8,11), gravedad específica plasmática (11), gravedad específica urinaria (12,13), y peso.…”

Section: Introductionunclassified

Administración de agua y glucosa en las primeras horas de vida. ¿Es realmente necesario?.

Chiarella¹,

Zegarra²,

Caravedo³

2013

Rev Med Hered

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SUMMARYThe neonatal feeding therapy has been changed in the last years, exclusive breast feeding is stimulated. Some people doubts about needs of suplementation during the first hours of life. 103 newborns were included, all were normal, without any risk factors. Divided in 2 groups: EBF (52): Exclusive Breast Feeding and SBF (51): Suplementation (two 5% dextrose suplements) and Breast Feeding. Glycemia, hematocrit, EPG (Especific plasmatic gravity) were used for statistics. Glycemia at birth oscillated between 75 and 98mg%, after 6 hours decreased to 63 and 78mg%. Highest media and biggest standard desviation, has been seen in SBF group at 6 of live. Glycemia rised more quickly in patients who received suplement. The hematocrit, EPG and weight have similar variations in al groups. We conclude that administration of dextrose suplement is unnecessary to keep the glycemia and hidratation of the normal newborn even if breast feeding starts within the first 12 hours of life (Rev Med Hered 1993;1:20-25) KEY WORDS: Breast feeding, newborn, suplementation, newborn glycemia. RESUMENLas prácticas en la nutrición del recién nacido han variado; se fomenta la lactancia materna exclusiva y se discute la necesidad de administrar un suplemento de glucosa y agua durante las primeras horas de vida para mantener la glicemia e hidratación. Para investigar al respecto se estudiaron 103 neonatos normales y sin factores de riesgo, divididos en 2 grupos: Lactancia Materna Exclusiva (LME) (52), Lactancia Mixta (LMX) (51), 2

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Changes in body water distribution during the first two weeks of life.

Cited by 72 publications

References 18 publications

Bromide Space Studies in Infants of Low Birth Weight

Bromide Space Studies in Infants of Low Birth Weight

Atenolol elimination in the neonate.

Administración de agua y glucosa en las primeras horas de vida. ¿Es realmente necesario?.

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