Changes in bone mass and bone turnover following tibial shaft fracture

Veitch, S.; Findlay, S. C.; Hamer, A. J.; Blumsohn, Aubrey; Eastell, Richard; Ingle, B. M.

doi:10.1007/s00198-005-2025-y

Cited by 121 publications

(132 citation statements)

References 21 publications

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“…Furthermore, ALP activity is a marker of osteoblastic activity; that is, for bone turnover and bone remodeling. ALP level in serum increases during bone healing after fracture 28,29) . ALP functions in dentine mineralization and is retained as a marker of fully differentiated odontoblasts 27) .…”

Section: Discussionmentioning

confidence: 99%

Gypsum-based biomaterials: Evaluation of physical and mechanical properties, cellular effects and its potential as a pulp liner

Low¹,

Yusof²,

Reza

et al. 2015

Dental Materials Journal

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This in vitro study aimed to evaluate setting time and compressive strength of gypsum-based chitosan biomaterials and its effect on proliferation of stem cells from human exfoliated deciduous teeth (SHED) and alkaline phosphatase (ALP) activity. Pure-GYP was mixed with water (2.5 g: 1.9 mL); Gyp-CHT was prepared with gypsum, chitosan, and water (2.5 g: 0.285 g: 1.9 mL). Cell viability and ALP activity were assessed at different periods. Data were analyzed using SPSS (p<0.05). The setting times were 2.7 min and 2.8 min for pure-GYP and Gyp-CHT, respectively. Significantly higher compressive strength was observed with Gyp-CHT. SHED treatments with both materials were not cytotoxic. ALP was consistently higher in the treated groups compared with the control. Cellular attachments were evident with SEM. Excellent cellular viability with pure-GYP and Gyp-CHT, as well as increased ALP activities, suggested the possibility of tertiary dentin formation. Further studies are necessary to evaluate the biomaterials for its pulp protective potentialities.

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Section: Discussionmentioning

confidence: 99%

Gypsum-based biomaterials: Evaluation of physical and mechanical properties, cellular effects and its potential as a pulp liner

Low¹,

Yusof²,

Reza

et al. 2015

Dental Materials Journal

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“…The initial decrease in bone formation markers and the marked increase in ICTP immediately after fracture are mediated by immobilization and osteosynthesis after injury. Markers of bone turnover remain increased even after bone union is completed (11,(17)(18)(19). Background: Training of clinical pathologists is evolving and must now address the 6 core competencies described by the Accreditation Council for Graduate Medical Education (ACGME), which include patient care.…”

confidence: 99%

Changes in Biochemical Markers after Lower Limb Fractures

Stoffel

Engler²,

Kuster

et al. 2007

Clinical Chemistry

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Background:The bone remodeling sequence after bone fracture changes the concentrations of biochemical bone markers, but the relationships of fracture size and of healing time to changes in biomarkers are unclear. The present pilot study was undertaken to determine the changes found in serum bone markers after plate osteosynthesis of closed distal tibial and malleolar fractures during a study period of 24 weeks.

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“…Several investigators have suggested the type and location of a fracture might affect expression of bone markers during the fracture healing process, with bone markers in diaphyseal tibial fractures taking greater time to elevate than ankle [48,49] or distal radial fractures [25]. Nakagawa et al [31] also suggested that a larger bone surface and longer time to union might contribute to different degrees of bone marker changes.…”

Section: Discussionmentioning

confidence: 99%

A Fracture Does Not Adversely Affect Bone Mineral Density Responses after Teriparatide Treatment

Unnanuntana

Ton

Kleimeyer

et al. 2012

Clinical Orthopaedics &Amp; Related Research

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Background Fracture leads to local and systemic catabolic physiologic changes. As teriparatide is an agent used to treat osteoporosis in patients with fragility fractures, it is unclear whether teriparatide treatment alters bone mineral density (BMD) and bone markers when given to patients with fractures. Questions/purposes We asked whether BMD and bone marker responses would be blunted in patients with fractures placed on teriparatide after fracture compared with patients without fractures on teriparatide. Patients and MethodsWe retrospectively collected data from 141 patients treated with teriparatide for osteoporosis. Seventy-seven patients received teriparatide after fractures (fracture group), whereas 64 were treated for other indications (nonfracture group). We determined BMD at the lumbar spine and at the proximal femur before and 12 and 24 months posttreatment. Bone markers (urine N-telopeptide [urine NTX], bone-specific alkaline phosphatase [BALP]) were measured at baseline and 3, 12, and 24 months posttreatment. Results Mean lumbar spine and hip BMDs at last followup increased from baseline with no differences between groups to approximately 9% and 4% at 24 months, respectively. Both bone markers increased from baseline in the nonfracture group, peaking at 12 months. For the fracture group, only urine NTX increased at 3 and 12 months posttreatment. Although the peak levels of both bone markers in the nonfracture group were greater, there was no difference between the two groups. Conclusions Fracture does not have a negative effect on the BMD and bone marker responses to teriparatide treatment. Clinicians should anticipate comparable BMD responses when treating patients with teriparatide for osteoporotic fractures and for other indications. Level of Evidence Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

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Changes in bone mass and bone turnover following tibial shaft fracture

Cited by 121 publications

References 21 publications

Gypsum-based biomaterials: Evaluation of physical and mechanical properties, cellular effects and its potential as a pulp liner

Gypsum-based biomaterials: Evaluation of physical and mechanical properties, cellular effects and its potential as a pulp liner

Changes in Biochemical Markers after Lower Limb Fractures

A Fracture Does Not Adversely Affect Bone Mineral Density Responses after Teriparatide Treatment

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