Changes in Bone Metabolism in Morbidly Obese Patients After Bariatric Surgery: A Meta-Analysis

Liu, Cong; Wu, Dan; Zhang, Jingfan; Xu, Duo; Xu, Wanfeng; Chen, Yu; Liu, Bingyang; Li, Ping; Li, Ling

doi:10.1007/s11695-015-1724-5

Cited by 135 publications

(118 citation statements)

References 47 publications

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“…Increases in bone turnover markers have also been observed in response to gastric banding and sleeve gastrectomy [10]. A meta-analysis of 10 studies involving a total of 344 patients confirmed that whilst total body, femoral neck, lumbar spine and pelvic BMD were significantly decreased post-surgery, serum or urinary concentrations of NTX were significantly elevated [54]. This meta-analysis noted interesting differences in serum concentrations of nutrients that are important for the maintenance of bone mass, namely calcium and vitamin D. That is, serum calcium concentrations were significantly reduced post-bariatric surgery, although no difference could be found in serum concentrations of vitamin D [54].…”

Section: Effect Of Bariatric Surgery On Bonementioning

confidence: 94%

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Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity

Harper

Pattinson

Fernando

et al. 2016

Hormone Molecular Biology and Clinical Investigation

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Background: New evidence suggests that obesity is deleterious for bone health, and obesity treatments could potentially exacerbate this. Materials and methods: This narrative review, largely based on recent systematic reviews and meta-analyses, synthesizes the effects on bone of bariatric surgery, weight loss pharmaceuticals and dietary restriction. Results and conclusions: All three obesity treatments result in statistically significant reductions in hip bone mineral density (BMD) and increases in bone turnover relative to pre-treatment values, with the reductions in hip BMD being strongest for bariatric surgery, notably Roux-en Y gastric bypass (RYGB, 8%-11% of pre-surgical values) and weakest for dietary restriction (1%-1.5% of pre-treatment values). Weight loss pharmaceuticals (orlistat or the glucagon-like peptide-1 receptor agonist, liraglutide) induced no greater changes from pre-treatment values than control, despite greater weight loss. There is suggestive evidence that liraglutide may increase bone mineral content (BMC) -but not BMD -and reduce fracture risk, but more research is required to clarify this. All three obesity treatments have variable effects on spine BMD, probably due to greater measurement error at this site in

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Section: Effect Of Bariatric Surgery On Bonementioning

confidence: 94%

“…BMD has been found to be significantly decreased post bariatric surgery, with differing results between surgery types [10,[54][55][56]. Most available information about the effects of bariatric surgery on bone comes from studies on RYGB.…”

Section: Effect Of Bariatric Surgery On Bonementioning

confidence: 99%

Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity

Harper

Pattinson

Fernando

et al. 2016

Hormone Molecular Biology and Clinical Investigation

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“…It belongs to the «safe organ preserving surgery», has a high effi ciency rate and is commonly chosen for treating extreme cases of obesity. However, issues with changes in bone metabolism have recently been brought to light in association to bariatric surgery [6][7][8][9].…”

Section: а о никоненко є і гайдаржі м бужґаmentioning

confidence: 99%

“…In addition, they reported signifi cant increase in serum or urinary N-telopeptide and in bone -specifi c alkaline phosphatase, accompanied by a decrease in bone mineral density (BMD) [8].…”

Section: а о никоненко є і гайдаржі м бужґаmentioning

confidence: 99%

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Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study.

Nykonenko

Gaidarzhi

Bužga

2016

ZMJ

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In addition to the positive effect of weight loosing after bariatric surgery, the post-operative period is often associated with signifi cant changes in bone metabolism.Aim. The aim of this study was to examine changes in bone turnover markers and indicators of dual-energy X-ray absorptiometry (DXA) within 12 months after laparoscopic greater curvature plication (LGCP).Materials and methods. We studied 54 patients from class III obesity who underwent LGCP. The average preoperative weight of the patients was 125.5±19.1 kg, and BMI of 43.0±4.9 kg/m 2 . The gender distribution of the cohort was 35.2% man and 64.8% women. At three time points after the operation (at 3, 6 and 12 months) control examination was conducted that included DXA and markers of bone metabolism.Results. After the surgical treatment we registered signifi cant reduction of all the anthropometric indicators (ρ<0.05; EWL 12 45.8±18.8%; EBL 12 55.1±23.4%). According to the controlled studies on the 12th months, a signifi cant increase in bone turnover markers was revealed (ρ<0.05; CTX, P1NP, OC, OPG, VTD) and reducing of PTH (ρ<0.05). The measure of DXA on the 12th month of observation showed no signifi cant changes in bone metabolism. Strong positive correlation was uncovered between markers of bone metabolism: CTX / P1NP (r=0.790, p=0.000), CTX/ OC, P1NP/OC (r=0.7, p=0.000), minor correlation between PTH/OC (r=0.249, p=0.027). We also report a minor and weak negative correlation between the markers of bone metabolism (CTX, P1NP, OC and VTD) and anthropometric data.Conclusions. Twelve months post LGCP markers of bone turnover (CTX, P1NP, OC, OPG, VTD) were signifi cantly increased. The increased level of VTD is associated with the loss of FAT. Also the change in DXA was detected. Зміни кісткового метаболізму після лапароскопічної плікації великої кривизни шлунка. Річне дослідження А. О. Никоненко, Є. І. Гайдаржі, М. БужґаНезважаючи на позитивний ефект втрати ваги після баріатричних операцій, післяопераційний період часто пов'язаний зі значними змінами в метаболізмі кісткової тканини.Мета роботи -вивчення динаміки маркерів ремоделювання кістки та показників її двоенергетичної рентгенівської абсорбціометрії протягом 12 місяців після лапароскопічної плікації великої кривизни шлунка.Матеріали та методи. Досліджували 54 пацієнти з ожирінням III ступеня, які перенесли лапароскопічну плікацію великої кри-визни шлунка. Середня передопераційна вага пацієнтів була 125,5±19,1 кг і ІМТ 43,0±4,9 кг/м 2 . Поділ за статтю був такий: 35,2% чоловіків і 64,8% жінок. Контрольне обстеження здійснили на 3, 6 і 12 місяці після операції. Обстеження включало вимір показників двоенергетичної рентгенівської абсорбціометрії та визначення маркерів кісткового метаболізму.Результати. Після хірургічного лікування зареєстрували значне зниження всіх антропометричних показників (ρ<0,05; EWL 12 45,8±18,8%; EBL 12 55,1±23,4%). Згідно з результатами досліджень через 12 місяців виявили значне збільшення маркерів ремоделювання кістки (ρ<0,05; CTX, P1NP, OC, OPG, VTD) та зниження PTH (ρ...

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Weight Management and Metabolic Surgery

Sudlow,

Pournaras,

le Roux

2024

Textbook of Diabetes

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Changes in Bone Metabolism in Morbidly Obese Patients After Bariatric Surgery: A Meta-Analysis

Cited by 135 publications

References 47 publications

Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity

Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity

Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study.

Weight Management and Metabolic Surgery

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