Changes in bone mineral density of lumbar spine after pelvic radiotherapy

Chen, Helen H.W.; Lee, Bi Fang; Guo, How‐Ran; Su, Wei-Ren; Chiu, Nan Tsing

doi:10.1016/s0167-8140(02)00002-6

Cited by 35 publications

(20 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When comparing bone mineral densities of L2 to L5 between patients and matched control individuals, there were no statistically significant differences between bone mineral densities of all the vertebrae from 1 to 7 years after RT. The authors proposed that a possible explanation for their finding was that susceptibility to fracture after RT could occur without a change in bone mineral content, as we have suggested (18).…”

Section: Discussionmentioning

confidence: 67%

“…More recently, Chen et al (18) used DEXA scans to study the bone mineral content of patients treated for cervical cancer with cobalt-60 or high-energy photons to a total dose of 45-51 Gy to the whole pelvis followed by highdose-rate intracavitary brachytherapy. When comparing bone mineral densities of L2 to L5 between patients and matched control individuals, there were no statistically significant differences between bone mineral densities of all the vertebrae from 1 to 7 years after RT.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bone Density Changes After Radiation for Extremity Sarcomas: Exploring the Etiology of Pathologic Fractures

Dhakal

Chen²,

McCance

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Bone Density Changes After Radiation for Extremity Sarcomas: Exploring the Etiology of Pathologic Fractures

Dhakal

Chen²,

McCance

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

“…On other hand, Chen et al . (27) showed no significant change in the BMDs (L2–L5) between women with CC treated with radiotherapy and matched controls. The current study showed that combination therapy of surgical castration and CCRT for premenopausal women with CC was associated with a significant decrease in the spine BMD.…”

Section: Discussionmentioning

confidence: 74%

Bone mineral loss induced by anticancer treatment for gynecological malignancies in premenopausal women

Nishio

Tanabe

Maruoka

et al. 2013

Endocrine Connections

View full text Add to dashboard Cite

ObjectiveAlthough surgical menopause may increase the risks of osteoporosis, few studies have investigated the influence of chemotherapy and radiation therapy. The aim of this study is to evaluate the effects of treatments for gynecological malignancies on bone mineral density (BMD).MethodsThis study enrolled 35 premenopausal women (15 ovarian cancers (OCs), 9 endometrial cancers (ECs), and 11 cervical cancers (CCs)) who underwent surgical treatment that included bilateral oophorectomy with or without adjuvant platinum-based chemotherapy in OC and EC patients, or concurrent chemo-radiation therapy (CCRT) in CC patients according to the established protocols at the Osaka Medical College Hospital between 2006 and 2008. The BMD of the lumbar spine (L1–L4) was measured by dual-energy X-ray absorptiometry, and urine cross-linked telopeptides of type I collagen (NTx) and bone alkaline phosphatase (BAP) were assessed for evaluation of bone resorption and bone formation respectively. These assessments were performed at baseline and 12 months after treatment.ResultsAlthough the serum BAP was significantly increased only in the CC group, a rapid increase in the bone resorption marker urinary NTx was observed in all groups. The BMD, 12 months after CCRT was significantly decreased in the CC group at 91.9±5.9% (P<0.05 in comparison to the baseline).ConclusionThis research suggests that anticancer therapies for premenopausal women with gynecological malignancies increase bone resorption and may reduce BMD, particularly in CC patients who have received CCRT. Therefore, gynecologic cancer survivors should be educated about these potential risks and complications.

show abstract

“…(28) Nevertheless, there have been clinical studies that have reported the diminution of bone mineral content in the lumbar spine of cervical cancer patients following radiation. (29) Hamada et al described disturbances in bone mineral metabolism of the lumbar vertebra that might be occurring in the early phase of radiation. (30) …”

Section: Discussionmentioning

confidence: 99%

The effect of Amifostine prophylaxis on bone densitometry, biomechanical strength and union in mandibular pathologic fracture repair

Tchanque-Fossuo

Donneys

Sarhaddi

et al. 2013

Bone

View full text Add to dashboard Cite

Background Pathologic fractures (Fx) of the mandibles are severely debilitating consequences of radiation (XRT) in the treatment of craniofacial malignancy. We have previously demonstrated Amifostine’s effect (AMF) in the remediation of radiation-induced cellular damage. We posit that AMF prophylaxis will preserve bone strength and drastically reverse radiotherapy-induced non-union in a murine mandibular model of pathologic fracture repair. Materials and Methods Twenty-nine rats were randomized into 3 groups: Fx, XRT/Fx, and AMF/XRT/Fx. A fractionated human equivalent dose of radiation was delivered to the left hemimandibles of XRT/Fx and AMF/XRT/Fx. AMF/XRT/Fx was pre-treated with AMF. All groups underwent left mandibular osteotomy with external fixation and setting of a 2.1mm fracture gap post-operatively. Utilizing micro-computed tomography and biomechanical testing, the healed fracture was evaluated for strength. Results All radiomorphometrics and biomechanical properties were significantly diminished in XRT/Fx compared to both Fx and AMF/XRT/Fx. No difference was demonstrated between Fx and AMF/XRT/Fx in both outcomes. Conclusion Our investigation establishes the significant and substantial capability of AMF prophylaxis to preserve and enhance bone union, quality and strength in the setting of human equivalent radiotherapy. Such novel discoveries establish the true potential to utilize pharmacotherapy to prevent and improve the treatment outcomes of radiation-induced late pathologic fractures.

show abstract

Changes in bone mineral density of lumbar spine after pelvic radiotherapy

Cited by 35 publications

References 19 publications

Bone Density Changes After Radiation for Extremity Sarcomas: Exploring the Etiology of Pathologic Fractures

Bone Density Changes After Radiation for Extremity Sarcomas: Exploring the Etiology of Pathologic Fractures

Bone mineral loss induced by anticancer treatment for gynecological malignancies in premenopausal women

The effect of Amifostine prophylaxis on bone densitometry, biomechanical strength and union in mandibular pathologic fracture repair

Contact Info

Product

Resources

About